trh

Protirelin (Thyroliberin) is a tripeptide that stimulates the release of thyrotropin and prolactin.

Thyrotropin-Releasing Hormone (TRH), Free Acid (TRH-OH), induces various thyroidal and non-thyroidal effects, most notably the feedback regulation of thyroid hormone levels.

(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH), acts as a negative modulator of TRH's cholinergic effect in the mouse brain, significantly reducing TRH-induced release of extracellular acetylcholine in the hippocampus. Resistant to metabolism by thyroliberinase, (Glu2)-TRH exhibits neuroprotective, antidepressant, and anticonvulsant properties in the CNS [1].

'[Phe2]-TRH, a thyrotropin-releasing hormone analogue, exhibits conformational similarity to Leu5-enkephalin [1].'

Prepro-TRH-(160-169), a connecting peptide of the thyrotropin-releasing hormone prohormone (pro-TRH), enhances TRH-induced thyrotropin (TSH) release [1].

TRH-glycine (TRH-gly) serves as a precursor to thyrotropin-releasing hormone (TRH), capable of inducing the release of thyrotropin (TSH) and prolactin [1].

Thyrotropin Releasing Hormone Precursor Peptide

Protirelin Acetate(24305-27-9 free base) (Thyroliberin Acetate) is a tripeptide that stimulates the release of thyrotropin and prolactin.

PGlu-3-methyl-His-Pro-NH2 TFA enhances binding to pituitary TRH receptors, thereby increasing the stimulation of thyroid-stimulating hormone (TSH) release from the pituitary.

Histidylprolineamide is the N-terminal of TRH.

JKC363 TFA is a selective melanocortin MC4 receptor antagonist that exhibits a 90-fold higher affinity for the MC4 receptor (IC50=0.5 nM) compared to the MC3 receptor (44.9 nM). This compound effectively inhibits the α-MSH-induced stimulation of TRH release. It also demonstrates an anti-hyperalgesic effect [1] [2].

Protirelin Acetate (TRH Acetate) is a thyrotropin-releasing hormone, stimulating the release of thyrotropin and prolactin from the anterior pituitary.

Potent and selective melanocortin MC4 receptor antagonist (IC50 values are 0.5 and 44.9 nM at MC4 and MC3 respectively) that antagonizes the effects of α-MSH. Suppresses thyrotropin-releasing hormone (TRH) release, attenuates food intake and reduces forma