sumoylation

N106 is an activator of the SUMO-activating enzyme, E1 ligase, and triggers intrinsic sumoylation of SERCA2a. N106 can be used in studies about heart failure.

2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.

Subasumstat (TAK-981), a selective inhibitor of the SUMOylation enzymatic cascade, has potential immune-activating and antineoplastic activities.

Ginkgolic Acid (Romanicardic acid) C15:1 represses curli genes and prophage genes in EHEC.

SAE-IN-2 (compound 6) is a potent inhibitor of sumoylation-activating enzyme (SAE) with an IC50 value of 27.8 nM.

ML-93 is an orally active SAE inhibitor with an IC50 value of 0.4 μM. It effectively inhibits the SUMOylation pathway in HCT116 cells and demonstrates potent antitumor activity in HCT116 colorectal cancer xenograft models. ML-93 is applicable in colorectal cancer research.

COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).

CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor.

Ginkgolic Acid (Standard) is a reference standard for research and analysis in studies involving Ginkgolic Acid. Ginkgolic Acid (Romanicardic acid) C15:1 represses curli genes and prophage genes in EHEC.

Deoxyvasicinone is a natural alkaloid that acts as an inhibitor of translation, SUMOylation modification, and 15-human lipoxygenase in eukaryotic organisms.

(S)-Subasumstat is an isomer of Subasumstat. Subasumstat (TAK-981) is a pioneering selective inhibitor of the SUMOylation enzymatic cascade, with potential for activating the immune system and exhibiting antitumor properties.