steroidogenic factor-1 (sf-1, nr5a1)

RJW100 is a compound that acts as a potent agonist of liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1), exhibiting pEC50 values of 6.6 and 7.5, respectively. Additionally, RJW100 induces robust activation of the miR-200c (miRNA-200c, microRNA-200c) promoter.

(Iso)-RJW100 is a potent liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC 50 s of 6.4 and 7.2, respectively.

ML-180 (SR1848) is a potent inverse agonist of the orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) with an IC50 of 3.7 μM.

RJW103 TFA is a steroidogenic factor-1 (SF-1, NR5A1) activator with a human-derived pEC50 of 6.9. It exhibits a pEC50 of 5.9 for liver receptor homolog-1 (LRH-1, NR5A2). RJW103 TFA can be utilized in research related to cancer, endocrinology, and metabolic disorders, including adrenal cortex tumors.

SID7970631 is an isoquinolinone analog and a potent, selective submicromolar SF-1 (Steroidogenic Factor-1, NR5A1) inhibitor/inverse agonist with an IC50 of 255 nM. It inhibits SF-1-mediated transcriptional activity and exhibits significant cytotoxic effects on SF-1-dependent cancer cell lines. SID7970631 is widely utilized in research exploring therapeutic mechanisms for cancers such as adrenocortical carcinoma.