spliceosome — TargetMol Chemicals

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Search Results for " spliceosome "

Compounds

Cat No.	Product Name	Synonyms	Targets
T38889	Thailanstatin A
	Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50 =650 nM). Thailanstatin A inhibits multiple cancer cell lines via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the s...
T3628	Madrasin	DDD00107587	DNA/RNA Synthesis
	Madrasin (DDD00107587) is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly.		DNA/RNA Synthesis
T16551	Pladienolide B		Apoptosis
	Pladienolide B is a potent spliceosome inhibitor, a macrolide isolated from Streptomyces obtusususus Mer-12, which targets the SF3B1 subunit of the spliceosome.Pladienolide B exerts its antitumor effects by inhibiting pr...		Apoptosis
T4S0181	Hinokiflavone		MMP , BCL , E1/E2/E3 Enzyme
	Hinokiflavone, a novel modulator of pre-mRNA splicing activity both in vitro and in cellulo, inhibits the assembly of the spliceosome, particularly blocking the formation of the B complex. Additionally, it acts as a SUMO...		MMP , BCL , E1/E2/E3 Enzyme
T24023	E7107	E-7107,E 7107
	E7107 is a first-in-class inhibitor of precursor messenger ribonucleic acid spliceosome.
T69308	Spliceostatin A		Apoptosis
	Spliceostatin A is an anticancer agent and splicing inhibitor that inhibits the splicing mechanism of the spliceosome and inhibits mitotic clonal expansion and adipogenesis.Spliceostatin A induces cell cycle arrest in th...		Apoptosis
T62267	18-Deoxyherboxidiene
	18-Deoxyherboxidiene (RQN-18690A) is a potent inhibitor of angiogenesis. 18-Deoxyherboxidiene selectively acts on SF3b, a subcomplex of the U2 small nuclear ribonucleoprotein (snRNP) in the spliceosome. 18-Deoxyherboxidi...
T36684	Ipivivint
	Ipivivint, a first-in-class, orally active and potent CDC-like kinase (CLK) inhibitor, inhibits CLK1 (IC50=1.4 μM), CLK2 (IC50=0.002 μM) and CLK3 (IC50=0.022 μM). Ipivivint reduces Wnt pathway signaling gene expression t...