sost-1

SOST, also known as sclerostin, is a member of the cerberus DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. SOST is negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. SOST Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 22.58 kDa and the accession number is XP_005584428.2.

Expression system: HEK293 Cells
Length: 24-213, Full Length of Mature Protein
Activity: ELISA

Expression system: HEK293 Cells
Length: 24-213, Full Length of Mature Protein
Activity: ELISA

Expression system: HEK293 Cells
Length: 24-213, Full Length of Mature Protein
Activity: Cell Activity

Expression system: HEK293 Cells
Length: 24-213, Full Length of Mature Protein
Activity: Not Tested

A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass. Subsequent studies of LRP5 and sclerostin have provided important insights into the mechanisms by which these proteins regulate skeletal homeostasis. LRP-5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 96.51 kDa and the accession number is O75197-1.

A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass. Subsequent studies of LRP5 and sclerostin have provided important insights into the mechanisms by which these proteins regulate skeletal homeostasis. LRP-5 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 96 kDa and the accession number is O75197-1.