sod 3

GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD (cGMP sodium salt) , also known as cGMP, is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin. GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD activates protein kinase G (PKG) and modulates ion channel conductance, with signaling affecting diverse processes including smooth muscle relaxation and proliferation, phototransduction, and energy homeostasis.

1. ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion with potency comparable to that of rosiglitazone, a known modulator of adiponectin production. 2. Isoginkgetin has anti-tumor activity, the mechanistic basis is splicing inhibition , thus, pre-mRNA splicing inhibitors may represent a novel avenue for development of new anti-cancer agents.3. Isoginkgetin can inhibit tumor cell invasion by regulating phosphatidylinositol 3-kinase Akt-dependent matrix metalloproteinase-9 expression. 4. Isoginkgetin (0.3mg kg ip for 3d) can reduce the level of O2·- in plasma and erythroeyte and sometimes increase the activity of SOD in anoxic rats, the action being stronger than aspirin.

Morin monohydrate (oxylon pomiferum monohydrate) is a flavonoid extracted from Morus alba plant with anticancer, antioxidant, and anti-inflammatory activities, which reduces T-2 toxin-induced TNF-alpha, COX-2, IL-1β, IL-6, caspase-1, caspase-3, and caspase-11 mRNA. BML-286 is a WNP-containing WNP-containing BML-286, which reduces T-2 toxin-induced TNF-α, COX-2, IL-1β, IL-6, caspase-1, caspase-3, and caspase-11 mRNA expression, and ameliorates T-2 toxin-induced injury by decreasing malondialdehyde (MDA) and increasing superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GSH-PX).

Monascuspiloin (Monascinol), a compound extracted from rice fermented with Rhodobacter sphaeroides, exhibits antiandrogenic and antitumor activity and inhibits the proliferation of PC-3 and LNCaP.Monascuspiloin improves lipid metabolism and hepatic function in over-alcohol-addicted mice by decreasing hepatic MDA levels and increasing hepatic CAT, SOD and GSH levels.Monascuspiloin has been shown to improve lipid metabolism and hepatic function in over-alcoholized mice. Monascuspiloin regulates the transcription and protein expression of genes related to hepatic lipid metabolism and oxidative stress, and can be used to study alcohol-induced liver injury.