sacubitril

Sacubitril (AHU-377) is a potent NEP inhibitor with an IC50 of 5 nM and is a component of the heart failure medicine LCZ696.

Sacubitril/Valsartan (LCZ696) is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure.

Sacubitril hemicalcium salt (AHU377 calcium salt) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696. Sacubitril hemicalcium salt is a prodrug of LBQ657, which is an inhibitor of the zinc metallopeptidase neprilysin. Neprilysin degrades a variety of vasoactive peptides such as atrial and brain natriuretic peptide, bradykinin, adrenomedullin, and endothelin-1. Inhibition of neprilysin leads to an increased level of these peptides and, thus, antihypertensive effects. Formulations containing AHU377 in combination with the angiotensin II receptor antagonist valsartan are used to treat hypertension and heart failure.

(2S,4S)-Sacubitril (Sacubitril Impurity C) is a stereoisomer derived from Sacubitril which is a potent NEP inhibitor.

Sacubitril-(2S,4S)-Isomer ((2S,4S)-Sacubitril) is the isomer of Sacubitril which is a neprilysin inhibitor.

2R,4R-Sacubitril is an impurity of Sacubitril, which is used in combination with valsartan for the treatment of patients with heart failure.

2S,4R-Sacubitril is an impurity of Sacubitril, which is used in combination with valsartan [for the treatment of patients with heart failure].

(Z)2S,4R-Sacubitril is an impurity of Sacubitril, a compound used in combination with valsartan for treating patients with heart failure.

Sacubitril-13C4 hemicalcium salt is the carbon-13 and deuterium-labeled version of Sacubitril hemicalcium salt (T4200). Sacubitril (AHU-377) hemicalcium salt is a potent NEP inhibitor with an IC50 value of 5 nM. It is a component of the active pharmaceutical compound LCZ696, used in heart failure research.

Sacubitril-D4 hemicalcium salt is a deuterated form of Sacubitril hemicalcium salt (T4200). It is a potent NEP inhibitor with an IC50 of 5 nM.

Sacubitril-D4 calcium salt is a deuterated compound of Sacubitril calcium salt (T4200).

Sacubitril sodium (AHU-377) is a potent NEP inhibitor with an IC50=5 nM for the treatment of heart failure or in combination with antihypertensive agents.

2R,4S-Sacubitril (Sacubitril Enantiomer) is the impurity of Sacubitril which is a neprilysin inhibitor.

Sacubitril Enantiomer (ahu377 isomer 2) is the enantiomer of Sacubitril which is a neprilysin inhibitor.

Sacubitril metabolite-13C4 is the 13C labeled compound of Sacubitril metabolite.

Sacubitril sodium (Standard) is a reference standard for research and analysis in studies involving Sacubitril sodium. Sacubitril sodium (AHU-377) is a potent NEP inhibitor with an IC50=5 nM for the treatment of heart failure or in combination with antihypertensive agents.

Sacubitril Sodium Salt-[13C4] (Standard) is a reference standard of Sacubitril Sodium Salt-[13C4] intended for quantitative analysis, quality control, and related biochemical research applications.

Sacubitril Metabolite Lbq 657-[13C4] (Standard) is a reference standard of Sacubitril Metabolite Lbq 657-[13C4] intended for quantitative analysis, quality control, and related biochemical research applications.

Sacubitril-[D4] Hemicalcium Salt (Standard) is a reference standard of Sacubitril-[D4] Hemicalcium Salt intended for quantitative analysis, quality control, and related biochemical research applications.

Sacubitril Metabolite Lbq 657-[D4] (Standard) is a reference standard of Sacubitril Metabolite Lbq 657-[D4] intended for quantitative analysis, quality control, and related biochemical research applications.

Sacubitrilat (LBQ-657) (LBQ657) is an effective inhibitor of active neprilysin (NEP).

Sacubitrilat (Standard) is a reference standard for research and analysis in studies involving Sacubitrilat. Sacubitrilat (LBQ-657) (LBQ657) is an effective inhibitor of active neprilysin (NEP).

Sacubitrilatimpurity 34 is an impurity found in Sacubitrilat.