pi5p4kα

PI5P4Kα-IN-1 (Compound 13) is a phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) inhibitor with IC50 values of 2 μM for PI5P4Kα and 9.4 μM for PI5P4Kβ, potentially applicable in cancer, metabolic, and immunological disorder studies [1].

I-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4Kα (IC50: 1 µM).I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and exhibits preferential cytotoxicity to nutrient-deficient PANC1 cells.

PI5P4Ks-IN-2 is an inhibitor of the phosphatidylinositol 5-phosphate 4-kinase PI5P4Kγ. Targeting the PI5P4K isoforms, PI5P4Ks-IN-2 inhibited PI5P4Kα, PI5P4Kβ, PI5P4Kγ, and PI5P4Kγ+, with IC50 values of <4.3, <4.6, 6.2, and 0.32, respectively.

CC260, a selective inhibitor for PI5P4Kα and PI5P4Kβ with Kis of 40 nM and 30 nM respectively, exhibits minimal to no inhibition against other protein kinases like Plk1 and RSK2. It is applicable in the research of cell energy metabolism, diabetes, and cancer[1].

PI5P4Ks-IN-3 (compound 30) is a covalent inhibitor of PI5P4K with inhibition constants (IC50s) of 1.34 μM for PI5P4Kα and 9.9 μM for PI5P4Kβ, but demonstrates weak cellular activity [1].

ARUK2007145 is a potent, cell-active inhibitor targeting both PI5P4Kα and PI5P4Kγ isoforms with pIC50 values of 7.3 and 8.1, respectively [1].

CVM-05-002 is an inhibitor of PI5P4K, characterized by IC 50 values of 0.27 μM for PI5P4Kα and 1.7 μM for PI5P4Kβ [1].