phospholipase a-1

Expression system: E. coli
Length: 28-474, Full Length of Mature Protein
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 28-474, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 28-474, Full Length of Mature Protein
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 32-408, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 1-252, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 34-412, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 1-372, Full Length
Activity: Not Tested

Otolin (OTOL1), also known as C1qTNF15, is an approximately 65 kDa protein found in the otoconial membrane lining the cochlea and vestibular labyrinth of the inner ear. Collagen-like protein specifically expressed in the inner ear, which provides an organic scaffold for otoconia, a calcium carbonate structure in the saccule and utricle of the ear. It associates into multimers and disulfide-linked oligomers and also associates with other otoconial proteins including and Otoconin-90 (also known as PLA2G2A, PLA2L, and phospholipase A2 homolog) and Cerebellin-1. It is extensively glycosylated and has multiple hydroxylated proline residues in the collagenous regions.

Expression system: E. coli
Length: 1-323, Full Length
Activity: Not Tested

Expression system: HEK293 Cells
Length: 58-503, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 52-506, Partial
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 1-342, Full Length
Activity: Not Tested

The low molecular weight phosphotyrosine phosphatase (LMW-PTP), also known as Acid phosphatase 1 (ACP1), belongs to the low molecular weight phosphotyrosine protein phosphatase family are involved in the regulation of important physiological functions, including stress resistance and synthesis of the polysaccharide capsule. ACP1 LMW-PTP is an enzyme involved in platelet-derived growth factor-induced mitogenesis and cytoskeleton rearrangement. LMW-PTP is able to specifically bind and dephosphorylate activated PDGF receptor, thus modulating PDGF-induced mitogenesis. In vitro, LMW-PTP was found to efficiently dephosphorylate activated FcgammaRIIA and LAT, but not Syk or phospholipase Cgamma2. The overexpression of LMW-PTP inhibited activation of Syk downstream of FcgammaRIIA and reduced intracellular Ca(2+) mobilization. It been demonstrated that LMW-PTP is responsible for FcgammaRIIA dephosphorylation, and is implicated in the down-regulation of cell activation mediated by this ITAM-bearing immunoreceptor. In addition, ACP1 is a highly polymorphic phosphatase that is especially abundant in the central nervous system and is known to be involved in several signal transduction pathways.

Expression system: HEK293 Cells
Length: 1-142, Full Length
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-195, Full Length
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-188, Partial
Activity: Not Tested

Expression system: E. coli
Length: 997-1337, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 26-269, Partial
Activity: Not Tested

Expression system: E. coli
Length: 1-181, Full Length
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 1-890, Full Length
Activity: Not Tested