phenothiazine

Phenothiazine (ENT 38) is a class of agents exhibiting antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Phenothiazines antagonize the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain, potentially preventing chemotherapy-induced emesis.

Acetophenazine dimaleate is an antipsychotic agent, effective in anxious depression. Acetophenazine dimaleate primarily targets the dopamine D2 receptor.

Fluphenazine decanoate is dopamine D2 receptor blocke,and is a long-acting phenothiazine neuroleptic that used to treat schizophrenia.

Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic activity. It is a selective antagonist of mycotoxins M1 receptors, exhibiting high (Ki=84 nM, M1 receptors) and low (Ki=1.65 μM, M2 receptors) affinity, with a 20-fold difference. Oxomemazine is an antihistamine and anticholinergic agent used in cough studies[1][2].

3-Amino-1-(2-chloro-10H-phenothiazin-10-yl)-1-propanone is involved in the synthesis of phenothiazine series compounds.

3-(4'-Carboxyphenyl)imino-3H-phenothiazine is a Bio-reagent, fine chemical.

3-(2',5'-Disulfophenylimino)-3H-phenothiazine is a Bio-reagent, fine chemical.

2-Cyano-phenothiazine, with CAS No. 38642-74-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-Cyano-phenothiazine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1-Chloro-10H-phenothiazine, with CAS No. 1910-85-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-Chloro-10H-phenothiazine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

10H-phenothiazine 5-oxide, with CAS No. 1207-71-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 10H-phenothiazine 5-oxide provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Phenothiazine (Standard) is the standard substance of Phenothiazine, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Phenothiazine (ENT 38) is a class of agents exhibiting antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Phenothiazines antagonize the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain, potentially preventing chemotherapy-induced emesis.

carfenazine targets the Dopamine receptor and is used for schizophrenia research.

2-Methoxy Phenothiazine is light yellow or light gray solid.

2-Chlorophenothiazine is used as the intermediate of Chlorpromazine hydrochloride.

2-Methylthiophenothiazine, with CAS No. 7643-08-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-Methylthiophenothiazine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

RTC-5 (TRC-382) is a phenothiazine compound that has been specifically enhanced for its potent anti-cancer properties. It exhibits considerable effectiveness against an EGFR-driven cancer xenograft model. The mechanism behind its efficacy can be attributed to the simultaneous inhibition of PI3K-AKT and RAS-ERK signaling pathways.

PPA-904, a specific phenothiazine photosensitizer, is used in photodynamic therapy (PDT).

Quisultazine is a phenothiazine derivative with no central effects, can be classified as a non anti H2 antisecretory agent.

Fluphenazine dihydrochloride (Prolixin) is an inhibitor of phenothiazine-class D1DR and D2DR; In studies, Fluphenazine can be used to probe the effects and metabolic process of this commonly used dopamine antagonist.

Prochlorperazine Maleate (Capazine) is a phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS.

Promazine hydrochloride (Romtiazin hydrochloride) is a phenothiazine with actions similar to CHLORPROMAZINE but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.

Zuclopenthixol (cis-Clopenthixol) is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.

Biperiden (Bipariden) is a muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine.

Triflupromazine is a dopamine receptor D1/D2 antagonist and LHDA inhibitor that suppresses dopamine activity in the central nervous system (CNS) and promotes LDHA-mediated AMBRA1 ubiquitination, used for treating mental disorders, sedation, and antiemesis.