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Results for "

paclitaxel

" in TargetMol Product Catalog
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Paclitaxel
Taxol, NSC 125973
T096833069-62-4
Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy.
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7-Epi 10-desacetyl paclitaxel
7-Epi-10-deacetyltaxol, 10-Deacetyl-7-epipaclitaxel
T573878454-17-8
7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) shows IC50 values of 0.085 nM, against HeLa cells.
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10-Deacetyl-7-xylosyl paclitaxel
10-Deacetyl-7-xylosyltaxol, 10-Deacetyltaxol 7-Xyloside, 7-Xylosyl-10-deacetyltaxol, 10-Deacetylpaclitaxel 7-Xyloside
T574990332-63-1
10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) is a Paclitaxel derivative with improved pharmacological features and higher water solubility,used in Chinese clinics to treat cancer.
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Docetaxel
RP-56976, NSC 628503
T1034114977-28-5
Docetaxel (RP-56976), a semi-synthetic analog of paclitaxel, is a microtubule depolymerization inhibitor (IC50=0.2 μM) that attenuates the effects of bcl-2 and bcl-xL gene expression and exhibits apoptosis-inducing, anti-tumor activity.
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Baccatin III
Baccatin Ⅲ
T278827548-93-2
Baccatin III (Baccatin Ⅲ) is a polycyclic diterpene which can be used for the semi-synthesis of paclitaxel and analogs. It has immunomodulatory and anticancer chemotherapeutic activities.
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Atractylenolide I
T5S016773069-13-3
1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reduction of pro-inflammatory cytokines and LPS. 2. Atractylenolide-I significantly sensitizes the res
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N-Benzoyl-(2R,3S)-3-phenylisoserine
taxol side chain
T7054132201-33-3
N-Benzoyl-(2R,3S)-3-phenylisoserine (taxol side chain) is an intermediate in the synthesis of the potent anticancer drug Paclitaxel and is used to study the binding sites. It exhibits cytotoxic, antiviral, and immunomodulatory activities.
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Dihydrocephalomannine
T13653159001-25-9
Dihydrocephalomannine is similar to paclitaxel, showing reduced cytotoxicity and tubulin binding.
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7-Xylosyltaxol
T2S237890332-66-4
7-xylosyltaxol is a taxol (Paclitaxel) derivative, has antineoplastic activity.
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7-epi-Taxol
7-Epitaxol, 7-epi-Paclitaxel
T3S2372105454-04-4
1. 7-epi-Taxol (7-Epitaxol) is the major derivative of taxol found in cells and that its presence does not alter, in a major way, the overall biological activity of taxol.
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10-Deacetyltaxol
10-DAT, 10-Desacetyl Paclitaxel, Deacetyltaxol, 10-deacetyl-paclitaxel, Deacetyl Paclitaxel
T516578432-77-6
10-Deacetyltaxol (10-DAT) is extracted from Taxus brevifolia barks.
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Eleutherobin
T74761174545-76-7
Eleutherobin, a potent β-microtubule inhibitor with an IC50 value of 2 μM, exhibits cytotoxic activity against cancer cells at a potency comparable to Paclitaxel. This compound is derived from marine soft coral and is known for its anticancer activity. [1] [2]
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7-Xylosyl-10-deacetyltaxol B
7-xylosyl-10-Deacetylpaclitaxel B
TN133590332-64-2
7-Xylosyl-10-deacetyltaxol B (7-xylosyl-10-Deacetylpaclitaxel B) is a paclitaxel derivative from the Northeastern red bean tree (Picea abies) in the Sequoia family, with antitumor activity, and can be used for the synthesis of paclitaxel.
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Taccalonolide A
TN2254108885-68-3
Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these cellular effects,with cytotoxic and antimalarial activities. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells.
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N-Methyltaxol C
TN4616153083-53-5
N-methyltaxol C and paclitaxel can produce a positive inotropic effect in papillary muscle, without alterations in the action potential. They can induced conduction arrhythmias and reduce coronary flow and left ventricular systolic pressure in the isolate
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Isotenulin
TN917210092-04-3
Isotenulin inhibits the efflux function of P-glycoprotein (P-gp) by stimulating P-glycoprotein ATPase, helping to overcome multidrug resistance (MDR) in cancer cells. It exhibits cytotoxicity in multidrug-resistant cancer cells KB-vin and in sensitive cancer cells HeLaS3. Additionally, Isotenulin acts synergistically with Paclitaxel, Vinblastine, and Doxorubicin.
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