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Results for "

p2x2

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    28
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    4
    TargetMol | Peptide_Products
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    2
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    1
    TargetMol | Isotope_Products
P2X2/3 modulator-1
T751621217483-98-1
P2X2 3 Modulator-1 (Compound 46) serves as a modulator of P2X2 3 receptors and has applications in researching pain, central nervous system disorders, and inflammation [1].
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6-8 weeks
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Adenosine 5'-diphosphate
ADP, adenosine pyrophosphate, Adenosine diphosphate
T172358-64-0
Adenosine 5'-diphosphate (ADP) is a naturally occurring nucleotide derived from the dephosphorylation of ATP. Adenosine 5'-diphosphate is essential for cellular metabolism and induces platelet aggregation.
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Sivopixant
S-600918, Sivopixant
T400452414285-40-6
Sivopixant (S-600918) (S-600918) is a potent and selective antagonist of P2X3 receptor (P2X3 IC 50 =4.2 nM; P2X2 3 IC 50 =1100 nM). Sivopixant shows strong analgesic effect .
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AF-353
Ro-4
T2087865305-30-2
AF-353 (Ro-4), an effective and orally bioavailable antagonist of the P2X3 P2X2 3 receptor, inhibits human and rat P2X3 (pIC50= 8.0).
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TargetMol | Inhibitor Sale
RO-3
T55131026582-88-6
RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2 3 receptor
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Minodronic acid
Phosphonicacid,(1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis-, ONO-5920, YM-529
T8436180064-38-4
Minodronic acid(YM-529) is a P2X2 3 receptor antagonist with anticancer activity, directly or indirectly inhibiting the proliferation of cancer cells and inducing apoptosis. Minodronic acid has been shown to inhibit the metastasis of various types of cancer cells.Minodronic-acid has been used in the study of osteoporosis.
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6-8 weeks
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A-317491 sodium salt hydrate
A-317491 sodium salt hydrate (475205-49-3 free base)
T10204
A-317491 sodium salt hydrate is a non-nucleotide P2X3 and P2X2 3 receptor antagonist that inhibits receptor-mediated calcium flux.
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4-6 weeks
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P2X3 antagonist 34
BLU-5937
T105602417288-67-4
P2X3 antagonist 34, a potent, selective, and orally active antagonist, targets the P2X3 homotrimeric receptor, exhibiting IC50s of 25 nM, 92 nM, and 126 nM for human, rat, and guinea pig P2X3 receptors respectively. It shows reduced activity against P2X2 3 heterotrimeric receptors across human, rat, and guinea pig models. Notably, this compound demonstrates a significant anti-tussive effect without altering taste[1].
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8-10 weeks
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α,β-Methylene ATP trisodium
T135411343364-54-4
α,β-Methylene ATP trisodium, a phosphonate analog of ATP, is a selective P2X agonist that induces enhanced contraction of UBSM. α,β-Methylene ATP trisodium inhibits P2X1 and P2X3, but is inactive against P2X2, 4 and 7.
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8-10 weeks
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2-Methylthio-ATP tetrasodium
2-methylthio-atp-tetrasodium, 2-Methylthioadenosine triphosphate tetrasodium salt, 2-MeS-ATP tetrasodium
T22496100020-57-3
2-Methylthio-ATP tetrasodium (2-MeS-ATP tetrasodium) is a non-specific P2 receptor agonist, which can activate P2X2 and P2Y1 receptors and mimic the physiological effects of ATP by binding to P2 receptors, and is widely used in the study of cell signaling and metabolic processes. In addition, 2-Methylthio-ATP tetrasodium induces non-competitive inhibition of ADP-induced platelet aggregation in human.
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6-8 weeks
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Ro-51
Ro 51
T232451050670-85-3
dual P2X3 and P2X2/3 antagonist
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10-14 weeks
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TC-P 262
T23442873398-67-5
P2X3 and P2X2/3 receptor antagonist
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6-8 weeks
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α,β-Methylene-ATP dilithium
T38444104809-20-3
α,β-Methylene ATP dilithium, a phosphonic analog of ATP, serves as a ligand for P2X3 and P2X7 receptors. It is a potent agonist specifically targeting P2X1 and P2X3 receptors while exerting negligible activity on P2X2, P2X4, P2X5, P2X6, and P2X7 receptors.
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Gefapixant
RO 4926219, MK-7264, AF219
T50991015787-98-0
Gefapixant (AF219) is a P2X3 receptor (P2X3R) antagonist with IC50 of ~30 nM at recombinant hP2X3 homotrimers and 100-250 nM at hP2X2 3 heterotrimeric receptors.
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MRS2179 tetrasodium hydrate
T64078
MRS2179 tetrasodium hydrate, a competitive antagonist of the P2Y1 receptor, acts on the turkey P2Y1 receptor (Kb: 102 nM, pA2: 6.99) and exhibits an inhibitory effect on platelet aggregation. IC50: 1.15 μM), P2X3 (IC50: 12.9 μM), P2X2, P2X4, P2Y2, P2Y4 and P2Y6 receptors.
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10-14 weeks
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Camlipixant
BLU-5937
T678851621164-74-6
Camlipixant (BLU-5937) is an orally active purine P2X3 receptor antagonist that is potent, selective and competitive. camlipixant has an IC50 of 25 nM for the hP2X3 homotrimer. camlipixant can be used for the treatment of respiratory disorders and Camlipixant has a strong cough suppressant effect.
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PSB-10211
T6890866295-57-6
PSB-10211 is a potent competitive antagonist and positive modulator of the P2X2 receptor.
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6-8 weeks
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α,β-Methylene-ATP
T725907292-42-4
α,β-Methylene ATP, a phosphonic analog of ATP, functions as a ligand for P2X3 and P2X7 receptors, and acts primarily as a selective agonist for P2X1 and P2X3 receptors, exhibiting minimal to no activity on P2X2, P2X4 through P2X7 receptors.
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8-10 weeks
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Mambalgin 1 TFA
T75954
Mambalgin 1 TFA, a selective inhibitor of ASIC1a (with IC50 values of 192 nM for human ASIC1a and 72 nM for the ASIC1a 1b dimer), preferentially binds to the channel in its closed inactive state. It demonstrates selectivity for ASIC1a over a range of other channels, including ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2, and Kv1.2. In vivo, Mambalgin 1 TFA effectively prolongs the latency of the withdrawal response in mouse tail-flick and paw-flick tests.
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Emetine hydrochloride
NSC 33669
T8487114198-59-5
This novel compound is an orally bioavailable antagonist of P2X3 P2X2 3 receptors, exhibiting potent activity with a pIC50 of 8 in both human and rat, and a pIC50 of 7.3 specifically for the human P2X2 3 receptor. It demonstrates high brain penetration, evidenced by a brain to plasma ratio of 6, and effectively blocks agonist-evoked intracellular Ca2+ flux and inward currents within the nanomolar range (10 nM to 1 µM) in cell lines that express human P2X3 and P2X2 3 receptors recombinantly. The compound also shows favorable pharmacokinetic properties, with a half-life (t1 2) of 1.63 hours and a time to reach maximum concentration (Tmax) of 30 minutes.
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8-10 weeks
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AF-353 hydrochloride
P2X3 Purinergic Receptor Antagonist, AF353, P2X2 3 Purinergic Receptor Antagonist, AF353
T85192927887-18-1
This novel compound is an orally bioavailable antagonist of P2X3/P2X2/3 receptors, exhibiting potent activity with a pIC50 of 8 in both human and rat, and a pIC50 of 7.3 specifically for the human P2X2/3 receptor. It demonstrates high brain penetration, evidenced by a brain to plasma ratio of 6, and effectively blocks agonist-evoked intracellular Ca2+ flux and inward currents within the nanomolar range (10 nM to 1 µM) in cell lines that express human P2X3 and P2X2/3 receptors recombinantly. The compound also shows favorable pharmacokinetic properties, with a half-life (t1/2) of 1.63 hours and a time to reach maximum concentration (Tmax) of 30 minutes.
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8-10 weeks
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PPADS
T89112149017-66-3
PPADS is a P2 receptor antagonist with IC50 values of 68 nM (P2X1) and 214 nM (P2X3). This compound functions as an ATP (nucleotide) analog, competing for binding sites on the P2 receptors with ATP. Additionally, PPADS acts as a reversible competitive antagonist of the NAADP receptor. It is capable of reversing hyperalgesia, and it diminishes the enhanced NO NOS signaling and IL-1β production in both peripheral and central steps of the nervous system.
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10-14 weeks
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Minodronic acid-d4
TMIJ-00991807367-80-1
Minodronic acid-d4 is a deuterated compound of Minodronic acid. Minodronic acid has a CAS number of 180064-38-4. Minodronic acid(YM-529) is a P2X2 3 receptor antagonist with anticancer activity, directly or indirectly inhibiting the proliferation of cancer cells and inducing apoptosis. Minodronic acid has been shown to inhibit the metastasis of various types of cancer cells.Minodronic-acid has been used in the study of osteoporosis.
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20 days
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Mambalgin 1
TP20031609937-15-6
Selective ASIC1a inhibitor (IC50 values are 192 and 72 nM for human ASIC1a and ASIC1a/1b dimer, respectively). Binds to closed/inactive channel. Selective for ASIC1a over ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2 and Kv1.2 channels. Increases late
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