oxindole

Oxindole (Indolin-2-one) is an aromatic heterocyclic building block, and its 2-indolinone derivatives are lead compounds in kinase inhibitor research. The oxindole structure is utilized in receptor tyrosine kinase (RTK) inhibitors, such as SU4984 and intedanib, making the RTK family a significant therapeutic target for anti-cancer drug development.

Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla. It is an autophagy enhancer that promotes α-synuclein clearance through the Akt/mTOR pathway.

(E)-FeCP-oxindole is an inhibitor of VEGFR2 with IC50 of 214 nM.

(Z)-FeCP-oxindole is a selective inhibitor of VEGFR2 with an IC50 of 200 nM for humans and demonstrates anticancer activity.

Oxindole-d4 (2-Indolinone-d4) is a deuterium-labeled version of Oxindole. Oxindole (Indolin-2-one) serves as an aromatic heterocyclic building block, with its derivatives emerging as key compounds in kinase inhibitor research.

6-Bromooxindole is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

3-Methyloxindole is a phenolic viral inducer that is an acetylcholinesterase inhibitor.

2-(3-Hydroxy-2-oxoindolin-3-yl)-acetic acid is a naturally occurring organic acid containing an indole ring that is used in organic synthesis and biochemical research.

Roxindole (EMD 49980) is a selective dopamine autoreceptor and 5-HT1A dual agonist and inhibitor of 5-hydroxytryptamine (5-HT) uptake with antipsychotic and antidepressant activity.Roxindole can be used to study Parkinson's and neurodivergence.

6-Chlorooxindole, with CAS No. 56341-37-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 6-Chlorooxindole provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

5-CARBOXYOXINDOLE, with CAS No. 102359-00-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 5-CARBOXYOXINDOLE provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

7-Benzoyloxindole (Compound 4a) acts as a tubulin destabilizing agent. It disrupts tubulin structures, inhibiting tumor cell growth, and is employed in research on gastric and lung cancers.

Dopamine D2 autoreceptor agonist

5-Hydroxyoxindole has been identified as a urinary metabolite of indole, which is produced from tryptophane via the tryptophanase activity of gut bacteria [1]. 5-Hydroxyoxindole has lipid peroxidation inhibition activity and free radical DPPH scavenging

3-Hydroxy-3-acetonyloxindole is a natural product of Marsdenia, Asclepiadaceae. The catalog number is TN2938 and the CAS number is 33417-17-3. 3-Hydroxy-3-acetonyloxindole can be used as a reference standard.

5-Bromoindolin-2-one is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

XEN907 is a novel spiro oxindole NaV1.7 blocker. XEN907 also inhibits hNaV1.7 (IC50: 3 nM).

4-Methylphenoxyacetic acid-Oxindole-CF3 is the E3 ligase ligand component of L134. It is suitable for use in PROTAC synthesis.

Rankinidine is a hydroxyindole alkaloid discovered in methanol extracts of Gelsemium rankinii, suitable for biochemical experiments and drug synthesis research.

Corynoxine hydrochloride is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.

Anticancer agent 30 (compound 6f-Z) is a potent 3-arylidene-2-oxindole derivative that acts as a selective CDK2 inhibitor, showing significant anticancer activity and potential as a cancer treatment [1].

Corynoxine hydrochloride, a tetracyclic oxindole alkaloid extracted from the hooks of Uncaria macrophylla, functions as a natural autophagy enhancer, facilitating the removal of alpha-synuclein by activating the Akt/mTOR pathway [1].

STING agonist-12 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint consistent with STING activation.