opener

ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 is a potent and orally active KCNQ2/Q3 potassium channel opener (EC50: 0.38 μM). ICA-27243 also has antiepileptic and anticonvulsant effects.

Aprikalim (RP 52891) is an adenosine triphosphate potassium channel (KATP) opener that protects against nerve damage in a rabbit model of spinal cord ischemia.Aprikalim inhibits vasoconstriction and inhibits the elevation of [Ca2+]i during myocardial paralysis, and can be used to study cardiovascular disease.

Rilmakalim is a potassium channel opener. Rilmakalim shows antivasoconstrictor effect.

1-((3R,4S)-3-hydroxy-2,2-dimethyl-6-(phenylsulfonyl)chroman-4-yl)pyrrolidin-2-one is an isomer of Rilmakalim, a potassium channel opener (PCO), which can activate ATP-sensitive K+ channels in the heart or other tissues

PCO 400 is an analog of comakalim that acts as a selective and potent ATP-sensitive K+ channel opener.

Flupirtine maleate (Katadolon maleate), a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a specific neuronal potassium channel opener.

ICA 110381 is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy

ICA-105665 (PF-04895162) is a potent and orally active opener of neuronal Kv7.2/7.3 and Kv7.3/7.5 potassium channels. ICA-105665 had low cytotoxic potential in human hepatocytes but inhibited liver mitochondrial function and bile salt export protein (BSEP) transport (IC50 of 311 μM). ICA-105665 can penetrate the central nervous system (CNS) and has antiseizure effects [1][2][3][4].

U-89232 is an opener of the cardioselective KATP channel.

KRN 4884 is an opener of the K+ channel. KRN 4884 (0.1-3 μM) activates KATP channels in a concentration-dependent manner (EC50=0.55 μM), in the presence of intracellular ATP (1 mM).

Naminidil (BMS-234303) is an ATP-sensitive potassium channel opener with vasodilatory activity that was developed as a topical medication candidate for the treatment of androgenic alopecia. Naminidil is used in research to investigate potassium channel–mediated vasodilation, hair follicle biology, and localized drug delivery strategies.

Tifenazoxide is an effective and SUR1/Kir6.2 selective KATP channels opener. Tifenazoxide has an anti-diabetic effect, can inhibit glucose-stimulated insulin release in vitro and in vivo.

Y-26763 is a K+ channel opener and active metabolite of Y-27152. This is an ATP-sensitive K+ (KATP) channel activator.

Y-27152 is a prodrug of the KATP (Kir6) channel opener Y-26763 and is a long-acting K+ channel opener.

BMS-191095 hydrochloride is a mitochondrial KATP channel opener. It offers cardioprotective benefits without causing vasodilation or impacting electrophysiology. Its protective mechanisms include prolonging myocardial contraction during ischemia, enhancing contractile function post-reperfusion, and reducing lactate dehydrogenase (LDH) release.

IDOR-1104-0086 is an orally active Kv7 potassium channel opener capable of crossing the blood-brain barrier, with an EC50 of 210 nM. It demonstrates strong selectivity for the hERG channel, with an IC20 of 25 μM. IDOR-1104-0086 exhibits efficacy and good tolerability in two rodent epilepsy models and can be utilized in epilepsy studies.

P-1060 is a potassium channel opener, applicable in cardiovascular disease research.

Bimakalim (EMD-52692) is an opener of ATP-sensitive potassium channels. It can decrease MPO (myeloperoxidase) activity across the wall and mimics the effects of ischemic preconditioning by reducing infarct size, adenosine release, and neutrophil function in dogs.

Minoxidil (U10858) hydrochloride, an ATP-sensitive potassium channel (KATP) opener, functions as an efficacious oral antihypertensive and peripheral vasodilator, aiding in vasodilation and hair growth stimulation. Additionally, it serves as a potent inhibitor of soybean lipoxygenase with an IC50 value of 20 μM.

Cromakalim (BRL 34915) is an ATP-dependent K(+) channel opener and a smooth muscle relaxant.Cromakalim has antiepileptic and anticonvulsant activity and may be useful in studies of asthma and disorders associated with vasodilation.

ZM 226600 is an ATP-sensitive potassium channel opener with an EC50 value of 500 nM. ZM226600 has an inhibitory effect on spontaneous bladder activity.

SG 209 is an analog of nicorandil and acts as a K+ channel opener and nitrate-free coronary vasodilator.

Iptakalim, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine receptor (nAChR) antagonist. Iptakalim is also a K(ir) 6.1/SUR2B activator that can attenuate hypoxia-induced pulmonary arterial hypertension in rats by endothelial function protection.

KCO-912 is a potent and selective opener of ATP-dependent potassium (K ATP) channels. KCO-912 suppresses airways hyperreactivity at doses devoid of cardiovascular effects.