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Results for "

oat1

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    14
    TargetMol | Inhibitors_Agonists
  • Natural Products
    4
    TargetMol | Natural_Products
  • Isotope Products
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    TargetMol | Isotope_Products
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    TargetMol | Antibody_Products
Epaminurad HCl
URC-102 HCl, UR-1102 HCl, Epaminurad HCl(1198153-15-9 Free base)
T27275L1198153-46-6In house
Epaminurad HCl is a URAT1 inhibitor with partial inhibition of OAT1 and OAT3 (organic anion transporters).Epaminurad HCl is a pro-uric acid excretory agent used for the prevention and treatment of gout and hyperuricemia.
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OAT1/3-IN-2
T816292195434-05-8
OAT1 3-IN-2 (compound 8) is a dual inhibitor of OAT1 and OAT3, demonstrating potential protective effects against Cys-Hg toxicity in HEK-OAT1 cells (10 μM) and may safeguard renal function. This compound is useful for investigating mercury-induced nephrotoxicity [1].
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OAT1/3-IN-1
T8163038393-73-6
OAT1 3-IN-1 (compound 7), a dual inhibitor of OAT1 and OAT3, mitigates Cys-Hg toxicity in HEK-OAT1 cells at 10 μM and offers potential kidney protection. This compound is used in the investigation of mercury-induced renal damage [1].
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Cabotegravir
GSK744, GSK-1265744, S GSK1265744
T60981051375-10-0
Cabotegravir (S GSK1265744) (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (IC50: 3.0 nM).
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Lesinurad
RDEA594
T6875878672-00-5
Lesinurad (RDEA594) is a selective inhibitor of uric acid reabsorption which is used in combination with other agents in the therapy of gout. Lesinurad has had a limited clinical use but has not been associated with serum enzyme elevations during therapy or with instances of clinically apparent liver injury.
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Indican
NSC-87517, 3-Indoxyl-beta-D-glucopyranoside, NSC 87517, NSC87517, Indoxyl-β-D-glucoside
T19866487-60-5
Indican (Indoxyl-β-D-glucoside) is a natural protective compound that is used to protect the liver.
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Cyazofamid
IKF-916
T201605120116-88-3
Cyazofamid functions as a fungicide by impairing the production of ATP. It inhibits Organic Cation Transporter 3 (OCT3) and OAT1 with IC50 values of 1.54 and 17.3 μM, respectively.
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10-14 weeks
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Lesinurad sodium
RDEA-594 sodium, RDEA594 sodium, RDEA 594 sodium
T213011151516-14-1
Lesinurad sodium (RDEA594 sodium) is a selective inhibitor of uric acid reabsorption and is used in the study of cardiovascular diseases.
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7-10 days
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Diclofenac Acyl Glucuronide
Diclofenac Acyl-β-D-Glucuronide, D-1-O-G
T2716764118-81-6
Diclofenac Acyl Glucuronide (Diclofenac glucuronide) is an intestinal metabolite that accelerates intestinal ulcers.
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Epaminurad
T272751198153-15-9
Epaminurad (UR-1102) is an orally active, potent, and selective URAT1 (urate transporter 1) inhibitor with a Ki of 0.057 μM, and it inhibits OAT1 and OAT3 (organic anion transporter) modestly. Epaminurad is a uricosuric agent used for research on gout and hyperuricemia [1].
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1-2 weeks
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4'-hydroxy Trazodone
T3572153818-10-3
4'-Hydroxy Trazodone, a metabolite of the antidepressant and sedative trazodone, is an inhibitor of organic anion transporter 3 (OAT3; Ki = 16.9 μM) and is selective for OAT3 over OAT1 (Ki > 200 μM).
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KPH2f
T624322760615-09-4
KPH2f, a dual URAT1 GLUT9 inhibitor, demonstrates safety, oral activity, and efficacy, with inhibitory concentrations (IC50s) of 0.24 μM for URAT1 and 9.37 μM for GLUT9. It exhibits minimal effects on OAT1 and ABCG2, with IC50 values of 32.14 μM and 26.74 μM, respectively [1].
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10-14 weeks
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JBP485
T69889211868-63-2
JBP485 is an inhibitor of renal transporters OAT1 and OAT3. JBP485 is an antihepatitis agent as a substrate for intestinal PEPT1.
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6-8 weeks
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Indoxyl Sulfate-d5 potassium salt
T703131644451-34-2
Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40 6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). It also inhibits the organic anion transporter (OAT) isoforms OAT1 and OAT3 (Kis = 34.2 and 74.4 µM, respectively for the rat transporters) in S2 proximal tubule cells. Indoxyl sulfate (0.2 and 1 mM) increases superoxide anion and nitric oxide levels in isolated human mononuclear blood cells. It increases serum creatinine and blood urea nitrogen (BUN) levels in the 5 6 nephrectomized rat model of chronic renal failure when administered at a dose of 50 mg kg.
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6-8 weeks
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