nadh

NADH disodium salt hydrate, also known as Disodium NADH hydrate, functions as an orally active reduced coenzyme. It serves as a donor of ADP-ribose units in ADP-ribosylation reactions and acts as a precursor to cyclic ADP-ribose. Additionally, it contributes to cellular energy metabolism by acting as a renewable electron donor in processes such as glycolysis, β-oxidation, and the tricarboxylic acid (TCA) cycle [1].

NADH disodium salt (Disodium NADH) hydrate is the reduced form of nicotinamide adenine dinucleotide (NAD) that can donate electrons in a reducing reaction, becoming oxidized to produce NAD+. Various enzymes utilize NADH disodium salt hydrate plus H+ to reduce substrates, generating NAD+ and the reduced product.

NADH is a reduced coenzyme that can be taken orally. It serves as a donor of ADP-ribose units in ADP-ribosylation reactions and is a precursor of cyclic ADP-ribose. Additionally, NADH functions as a regenerative electron donor in cellular energy metabolism, including glycolysis, β-oxidation, and the tricarboxylic acid (TCA) cycle.

Rifamycin S is a potent DNA-dependent RNA polymerase inhibitor,is a quinone and an antibiotic agnet against Gram-positive bacteria

Cyclocurcumin is a minor curcuminoid derived from the rhizome of Curcuma longa that differs structurally from curcumin despite sharing the same molecular formula (C21H20O6), Cyclocurcumin features an α,β-unsaturated dihydropyranone moiety that drives trans–cis photoisomerization instead of the diketone/keto–enol tautomerism characteristic of curcumin. Cyclocurcumin demonstrates potent biochemical activities, including selective inhibition of human aromatase (CYP19A1) with an IC50 of 4.43 μM—approximately fivefold stronger than curcumin—making it valuable for studying estrogen-related pathways, and uniquely stimulates melanogenesis and melanin export in both melanocyte and melanoma models, positioning it as a promising research tool for investigating hypopigmentary skin disorders.

ethyl 4-chloro-2-oxo-1,2-dihydroquinoline-3-carboxylate inhibits NAD(P)H: quinone oxidoreductase 1.

IM-156 acetate, an activator of NADH dehydrogenase (IC50=2.2 μM) and AMP-activated protein kinase alpha (AMPKα), is an orally available and bioavailable inhibitor of mitochondrial oxidative phosphorylation (OxPhos).IM-156 acetate increases AMPKα activity and inhibits chlorhexadiene-induced peritoneal fibrosis and inhibit tumor growth in rats .

Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.

Pyridaben is a METI acaricide that inhibits mitochondrial electron transport at complex I (METI; Ki = 0.36 nmol/mg protein in rat brain mitochondria).

NADH-IN-2 (compound 8) is a Type II NADH dehydrogenase inhibitor.

NADH-IN-3 (Compound C4-1) is an NADH inhibitor with a minimum inhibitory concentration (MIC) of 4 μg/mL (13.042 μM) against the type II NADH dehydrogenase of Mycobacterium tuberculosis (Mtb). It effectively blocks ATP synthesis and demonstrates potent inhibitory effects on both single-drug (Rifampicin and Isoniazid) and multidrug-resistant (Mtb) strains, exhibiting antibacterial activity while maintaining low cytotoxicity towards HepG2 cells (SI: 16.52).

Thio-NADH is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Daporinad hydrochloride (FK 866 hydrochloride) is a potent nicotinamide-phosphate ribosyltransferase (NAMPT) inhibitor with potential anti-tumor and anti-angiogenic activity that induces apoptosis in tumor cells.Daporinad hydrochloride can be used in the study of inflammation and cancer.

Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) is an amino acid sequence in the carboxy-terminal heparin-binding domain of fibronectin that facilitates the assembly of mesenchymal stem cell (MSC) spheroids into larger aggregates.

Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) is a heparin-binding amino acid sequence located in the carboxy-terminal heparin-binding domain of fibronectin.

Fibronectin Adhesion-promoting Peptide acetate (Heparin Binding Peptide acetate) is one of the heparin-binding amino acid sequences found in the carboxy-terminal heparin-binding domain of fibronectin.

NITD-916 is an orally active and highly lipophilic inhibitor of Mycobacterium enoyl reductase InhA with an IC50 of 570 nM.NITD-916 is a potent 4-hydroxy-2-pyridone derivative that forms a ternary complex with InhA and NADH, preventing access to the fatty acyl substrate-binding pocket.NITD-916 exhibits antituberculosis activity.

NAD+ (β-Nicotinamide Adenine Dinucleotide) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH).

Diuron is an orally active benzoylurea herbicide against annual, perennial broadleaf weeds, and grass weeds. Diuron inhibits the production of ATP and NADH, thereby impairing plant photosynthesis, and also increases ROS production and promotes DMBA/BBN-induced bladder cancer development.

NADH disodium salt hydrate is a coenzyme of oxidoreductase. NADH acts as a regenerative electron donor during catabolic processes including glycolysis, the citric acid cycle and beta-oxidation.

sn-Glycerol 3-phosphate, produced by the reduction of dihydroxyacetone phosphate by NADH formed during glycolysis of the cytoplasmic glycerol 3-phosphate dehydrogenase pathway.

KL1333 (NQO1 activator 1) enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD(P)H: NQO1 as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation.

Glycerol 3-phosphate biscyclohexylammonium salt is an endogenous metabolite produced by cytosolic glycerol 3-phosphate dehydrogenase pathway.

MS-L6 is an inhibitor of the mitochondrial respiratory complex I (ETC-I) with uncoupling properties. This product blocks oxidative phosphorylation (OXPHOS) by inhibiting NADH oxidation and exerting uncoupling effects. MS-L6 reduces mitochondrial membrane potential, inhibits ATP production, and induces mitochondrial dysfunction and apoptosis in tumor cells.