nacetylglucosaminyltransferase

Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition of Cox (cyclooxygenase) and inhibits Cl-/HCO3- exchange activity. It also increases survival in a cystic fibrosis mouse model of the distal intestinal obstructive syndrome.

Glucosaminyl (N-acetyl) Transferase 2 (EC:2.4.1.150, GCNT2, GCNT5, NACGT1, N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, N-acetylglucosaminyltransferase, IGNT) is responsible for the formation of the I antigen in blood type and also plays a significant role in cancer.

N-Acetylglucosaminyltransferase IVa (MGAT4A) is a glycosyltransferase that enhances cancer cell migration, invasion, and adhesion capabilities. It increases the β1,4GlcNAc-branched glycans on tumor-associated glycoprotein integrin β1 (ITGB1), which is closely related to cell motility.

The enzyme α-1,4-N-Acetylglucosaminyltransferase 4 (EC 2.4.1, A4GNT) catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans and inhibits the growth of Helicobacter pylori (H. pylori).

β-1,3-N-Acetylglucosaminyltransferase 4 (EC:2.4.1.149, B3GNT4) is involved in the synthesis of poly-N-acetyllactosamine and functions with activity towards type 2 oligosaccharides.

N-Acetylglucosaminyltransferase 1 (EC:2.4.1.101, MGAT1) exhibits the typical characteristics of a type II transmembrane protein. N-acetylglucosaminyltransferase 1 is considered essential for normal embryogenesis.

N-Acetylglucosaminyltransferase III [EC:2.4.1.144, MGAT3] transfers a GlcNAc residue to the β-linked mannose of an N-linked oligosaccharide's trimannosyl core, resulting in the formation of bisected GlcNAc.