mercury

Dimercaprol (Dicaptol) is an anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisonings.

Succimer (Dimercaptosuccinic acid) is a Lead Chelator. The mechanism of action of succimer is as a Lead Chelating Activity.

Ammonium thiocyanate is an inorganic salt commonly used to determine iron content, capable of binding with various metal ions (including copper, silver, zinc, lead, and mercury).

MiADMSA (Monoisoamyl DMSA) is a lipophilic chelating agent that has shown potential as a chelator detoxifier for arsenic and several heavy metals, including lead, mercury, cadmium, and gallium arsenide. It mitigates oxidative stress induced by sodium tungstate and improves liver and immune system alterations caused by chronic copper poisoning in Sprague Dawley rats. Additionally, MiADMSA protects human keratinocytes ['HaCaT'] from arsenic-induced oxidative stress.

Merethoxylline is classified as a mercury-containing diuretic.

Thimerfonate, an alkyl mercury derivative, possesses bactericidal properties.

Decamethyltetrasiloxane, a non-cyclic silicone oligomer, is used in the methylation of mercury(II) salts. It is transformed by a specific microflora. In the natural environment, it is degraded by mechanisms similar to other organic compounds.

FIPI is an effective and selective phospholipase D inhibitor that reduces mercury-induced lipid signaling and thus protects aortic endothelial cells from cytotoxicity.

N-Acetyl-DL-penicillamine is a chelating agent.1,2,3It inhibits the binding of methyl mercury to isolated human erythrocytes by 50% and removes 50% of methyl mercury ions from methyl mercury-loaded blood cells when used at a concentration of 1 mM.1,2N-Acetyl-DL-penicillamine (3 mmol kg per day, p.o.) reduces the biological half-life of mercury and decreases liver, kidney, brain, and blood mercury levels, as well as increases urinary excretion of mercury in a concentration-dependent manner, in mice when administered following injection of methyl mercuric chloride. It decreases mercuric chloride-induced mortality in mice when administered orally at a dose of 1.6 mmol kg.3N-Acetyl-DL-penicillamine is also an analog of SNAP that does not generate nitric oxide and has been used as a negative control in experiments using SNAP.4,5

Thimerosal, a vaccine preservative containing mercury, is suspected to play a role in the development of neurodevelopmental disorders.

OAT1 3-IN-2 (compound 8) is a dual inhibitor of OAT1 and OAT3, demonstrating potential protective effects against Cys-Hg toxicity in HEK-OAT1 cells (10 μM) and may safeguard renal function. This compound is useful for investigating mercury-induced nephrotoxicity [1].

OAT1 3-IN-1 (compound 7), a dual inhibitor of OAT1 and OAT3, mitigates Cys-Hg toxicity in HEK-OAT1 cells at 10 μM and offers potential kidney protection. This compound is used in the investigation of mercury-induced renal damage [1].

Norbixin, a carotenoid found in B. orellana, exhibits various biological activities including binding to the peroxisome proliferator-activated receptor γ (PPARγ) with a Ki of 1.15 µM in a cell-free assay. At a dosage of 47.7 mg/kg, norbixin effectively alleviates hyperglycemia, hyperinsulinemia, and insulin resistance, in addition to reducing serum lipid levels, cardiac thiobarbituric acid reactive substances (TBARS), and glutathione (GSH) in rat cardio-metabolic syndrome models. It also lowers serum levels of oxidized LDL, aortic protein oxidation, and the atherosclerotic area in a rabbit cholesterol-induced atherosclerosis model. Furthermore, norbixin, administered at 0.1 and 1 mg/kg per day, minimizes mercury-induced DNA damage in rat hepatocytes and leukocytes and prevents photoreceptor degeneration in an Abca4-/- Rdh8-/- mouse model of age-related macular degeneration (AMD).

2,3-Dimercaptopropanesulfonate (DMPS) acts as a mercury chelator. It lowers renal mercury concentrations while elevating urinary mercury levels in both uninephrectomized and normal rats treated with mercuric chloride. In a mouse model of developmental toxicity induced by heavy metals, DMPS (administered at 180 or 360 mg/kg per day for four days) mitigates methylmercury chloride-induced increases in embryotoxicity and fetal and maternal mortality, while also preventing the reduction in fetal bone ossification when given to pregnant mice.

Thiomichler's ketone (4,4'-Bis(dimethylamino)thiobenzophenone) is a photometric reagent suitable for detecting gold, palladium, platinum, mercury, silver, and copper. Additionally, it serves as a biomaterial or organic compound used in life sciences research.

Tetramethylammonium perchlorate serves as an intermediate in organic and chemical synthesis. It is utilized in high-performance liquid chromatography (HPLC) as a mobile phase for the quantification of olanzapine, clozapine, and N-desmethylclozapine. Additionally, it acts as a supporting electrolyte in the electrochemical reduction of 1-bromodecane, 1-iodododecane, 2-iodooctane, and 2-bromooctane on a mercury cathode.