mek5

BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.

BIX02188 is a selective and potent MEK5 inhibitor that inhibits MEK5-induced apoptosis in cells expressing the oncogenic mutant FLT3-ITD.

BIX02189 is a potent and selective inhibitor of MEK5 and ERK5 (IC50: 1.5 nM and 59 nM).

TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.TA-02 especially inhibits TGFBR-2.

BIX02188 is a specific MEK5 inhibitor (IC50: 4.3 nM), also inhibits ERK5 catalytic activity (IC50: 810 nM), and does not inhibit closely related kinases MEK1 2, JNK2, and ERK2.

GW284543 (UNC10225170) is a selective inhibitor of MEK5.

GW 284543 hydrochloride is a selective inhibitor of MEK5 .

CS640 is a selective calmodulin-dependent kinase inhibitor, targeting multiple isoforms, namely CaMK1D, CaMK1B, CaMK1A, CaMK1G, PIP5K1C, MEK5, RIPK4, and MLK3, with respective IC50 values of 0.08, 0.03, 0.001, 0.001, 11.2, 0.025, 5.69, and 2.75 μM. Additionally, CS640 exhibits inhibitory properties toward CYP450 enzymes 2C9 and 2C19 with IC50 values of 6 and 10 μM, correspondingly [1].