m-133

M133 is a selective histone deacetylase HDAC1 and HDAC2 inhibitor and potent antitumor agent.

The M133 peptide is a coronavirus-specific CD4 T cell epitope. In mice infected with the neurotropic coronavirus (strain JHM of mouse hepatitis virus), the M133 peptide demonstrates immunodominance. It activates CD4 T cells by forming an MHC/peptide complex through binding with MHC II molecules, which is recognized by specific TCRs.

UCM-1336 (3,3′-(Octylimino)bis[N-phenylpropanamide]) is a potent ICMT inhibitor with an IC50 of 2 μM which is selective against the other enzymes involved in the post-translational modifications of Ras.

RM-133 is a promising pro-apoptotic agent which shows activity on various cancer cell lines.

UCM-13369 (Compound 4b) serves as an NPM1 inhibitor, effectively downregulating the pathway linked to mutant NPM1 C+ by specifically targeting the C-terminal DNA-binding domain of NPM1 C+. It induces apoptosis in AML cell lines and primary cells, making it a valuable tool for AML research [1].

Pefabloc is an irreversible serine proteinase inhibitor. Pefabloc efficiently inhibits both human and rat platelet activating factor (PAF)-degrading acetylhydrolase (acetylhydrolase).

Abacavir hydroxyacetate is an orally active nucleoside analog reverse transcriptase inhibitor. It has anti-HIV and immunomodulatory activity, induces arterial thrombosis in a mouse model, and can be used to study HIV infection.

Hydrocortisone cypionate (Standard) is the standard substance of Hydrocortisone cypionate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Hydrocortisone cypionate is a corticosteroid ester and synthetic glucocorticoid corticosteroid.

Hydrocortisone hemisuccinate (Standard) is the standard substance of Hydrocortisone hemisuccinate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Hydrocortisone hemisuccinate (hydrocortisone 21-hemisuccinate*free acid) is a corticosteroid used as an analytical and chromatography reagent.

Hydrocortisone valerate (Standard) is the standard substance of Hydrocortisone valerate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Hydrocortisone Valerate (Westcort) has anti-inflammatory, antipruritic and vasoconstrictive properties.

Eugenol (Standard) is a reference standard for research and analysis in studies involving Eugenol. Eugenol (Allylguaiacol) is a Standardized Chemical Allergen. The physiologic effect of eugenol is by means of Increased Histamine Release and Cell-mediated Immunity.

Syringaresinol diglucoside (Standard) is a reference standard for research and analysis in studies involving Syringaresinol diglucoside. Syringaresinol diglucoside (Syringaresinol-di-O-glucoside) protects the animals from the stress-induced decreases in sex behaviours and in rectal temperature, the stress-induced failure of retrieval of memory, and the stress-induced enlargement of adrenal gland.

Hydroxy Dimetridazole-d3 (Standard) is the standard substance of Hydroxy Dimetridazole-d3, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Hydroxy Dimetridazole-d3 is a deuterated compound of Hydroxy Dimetridazole. Hydroxy Dimetridazole has a CAS number of 936-05-0. Hydroxy Dimetridazole is a hydroxy metabolite of Dimetridazole which combats protozoan infections.

Hydroxy Ipronidazole-d3 (Standard) is the standard substance of Hydroxy Ipronidazole-d3, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Hydroxy Ipronidazole-d3 is a deuterated compound of Hydroxy Ipronidazole. Hydroxy Ipronidazole has a CAS number of 35175-14-5. L 12407 is an antiprotozoal drug of the nitroimidazole class. It is used for the treatment of histomoniasis in turkeys and for swine dysentery.

Hydroxychlorodenafil (Standard) is the standard substance of Hydroxychlorodenafil, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Hydroxychlorodenafil is a derivative of the phosphodiesterase 5 (PDE5) inhibitor sildenafil.

Hydroxymetronidazole (Standard) is the standard substance of Hydroxymetronidazole, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Hydroxymetronidazole (Metronidazole-OH) is a nitroimidazole compound that functions as a metabolite of Metronidazole. It is commonly employed in poultry research to investigate bacterial and protozoal diseases, as well as in the study of swine dysentery and genital trichomoniasis in cattle.

Hydroxyphenyllactic acid (Standard) is the standard substance of Hydroxyphenyllactic acid, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Hydroxyphenyllactic acid is an antifungal metabolite, fungi such as Lactobacillus sp. SK007.

Nitisinone-13C6is intended for use as an internal standard for the quantification of nitisinone by GC- or LC-MS. Nitisinone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD), which converts 4-hydroxyphenylpyruvate (HPPA) to homogentisate in the tyrosine catabolic pathway.1Nitisinone increases urinary levels of HPPA and 4-hydroxyphenyllactate (HPLA) in rats when administered at a dose of 10 mg/kg. Nitisinone (3 mg/kg) prevents the neonatal lethality of fumarylacetoacetate hydrolase (FAH) deficiency in mice when administered to pregnant dams.2It exhibits hepatoprotective effects inFAH-/-mice, such as prevention of increases in plasma levels of aspartate serine aminotransferase (AST) and conjugated bilirubin, when administration is continued following birth at a dose of 1 mg/kg. Nitisinone (100 μg) decreases urinary excretion of homogentisate and increases urinary excretion of HPPA, HPLA, and 4-hydroxyphenylacetate in a mouse model of alkaptonuria induced by ethylnitrosourea.3Formulations containing nitisinone have been used in the treatment of hereditary tyrosinemia type 1 (HT-1). 1.Ellis, M.K., Whitfield, A.C., Gowans, L.A., et al.Inhibition of 4-hydroxyphenylpyruvate dioxygenase by 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione and 2-(2-chloro-4-methanesulfonylbenzoyl)-cyclohexane-1,3-dioneToxicol. Appl. Pharmacol.133(1)12-19(1995) 2.Grompe, M., Lindstedt, S., al-Dhalimy, M., et al.Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type INat. Genet.10(4)453-460(1995) 3.Suzuki, Y., Oda, K., Yoshikawa, Y., et al.A novel therapeutic trial of homogentisic aciduria in a murine model of alkaptonuriaJ. Hum. Genet.44(2)79-84(1999)