loperamide

Loperamide hydrochloride (ADL 2-1294) is a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity.

Loperamide is a opioid-receptor selective agonist. Its chemical structure is similar to that of haloperidol and pethidine, and it is suitable for acute diarrhea as well as chronic diarrhea caused by various etiology.

Loperamide-D6 hydrochloride, a deuterium-labeled variant of Loperamide hydrochloride (T0209), acts as an opioid receptor agonist utilized for diarrhea treatment.

Loperamide phenyl, an impurity detected in Loperamide, is an opioid receptor agonist.

N-didesmethyl Loperamide, an active metabolite of the peripheral μ1-opioid receptor agonist loperamide, impedes electrically induced contractions in isolated guinea pig myenteric plexus (IC50 = 370 nM) and enhances the sensitivity of a chloroquine-resistant P. falciparum strain to chloroquine (EC50 = 482 nM). Notably, it achieves this without causing toxicity in A-10 vascular smooth muscle cells (IC50 = >10,000 nM).

Loperamide-D6 is a deuterated compound of Loperamide. Loperamide (T206056) has a CAS number of 53179-11-6.

Loperamide oxide (R 58425) is a secreted antidiarrheal agent that increases peristalsis and inhibits intestinal absorption of water and ions and is used in the study of chronic diarrhea in patients with Crohn's disease.

N-Desmethyl Loperamide is the primary metabolite of Loperamide and also a competitive substrate for P-glycoprotein. Loperamide is a selective μ-opioid agonist with antidiarrheal effects.

Loperamide hydrochloride (Standard) is the standard substance of Loperamide hydrochloride, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Loperamide hydrochloride (ADL 2-1294) is a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity.

Harman hydrochloride can directly induce CYP1A1 gene expression in an AhR-dependent manner and may represent a novel mechanism by which harman promotes mutagenicity, co-mutagenicity and carcinogenicity.

Harmane (Loturine) is a bio-active β-Carboline and monoamine oxidase inhibitor found in coffee and tobacco smoke.

ADL 08-0011 is an active metabolite of the μ-opioid receptor antagonist alvimopan. It is produced from alvimopan via amide hydrolysis by gut microbiota. ADL 08-0011 is a μ-opioid receptor antagonist (Ki = 0.25 nM). It is selective for μ-opioid receptors over κ- and δ-opioid receptors (Kis = 15.8 and 31.6 nM, respectively). ADL 08-0011 inhibits endomorphin 1-induced inhibition of electrically induced contraction of isolated guinea pig ileum (pA2 = 9.4). In vivo, ADL 08-0011 (0.03-1 mg/kg) reverses loperamide-induced delayed gastric emptying in a rat model of castor oil-induced diarrhea.

[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) (ID 305) is a selective NK2R agonist with an EC50 of 3.7 nM for hNK2R. This compound significantly reduces weight loss in diet-induced obesity (DIO) mouse models and improves Loperamide-induced urinary dysfunction in wild-type mice. It is applicable in the study of neurokinin receptor-mediated diseases such as obesity, insulin resistance, and type 2 diabetes.