l ap3

L-AP3 is a potent antagonist of metabotropic glutamate receptor (mGluR), demonstrating inhibitory effects on D-phosphoserine and L-phosphoserine with IC50 values of 368 μM and 2087 μM, respectively.

DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase.

20-O-Demethyl-AP3 is a secondary metabolite derived from Ansamitocin P-3. Ansamitocin P-3 is a macrocyclic antitumor antibiotic that exerts biological activity through inhibition of microtubule function. 20-O-Demethyl-AP3 is relevant for natural product chemistry, microtubule-associated signaling, and antimitotic mechanism investigations.

Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a highly selective, potent competitive inhibitor of P-glycoprotein (P-gp, ABCB1) with a Ki value of 59 nM. Zosuquidar trihydrochloride exhibits antitumor activity and can be used in research on tumors such as leukemia.