ispinesib

Ispinesib (SB-715992), a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived from quinazolinone, with antineoplastic properties.

F1-ispinesib is a heterobifunctional F1 autophagy degrader, comprising an RNA binding fragment (F1) and the LC3B ligand Ispinesib. It induces the degradation of COL15A1 mRNA through an LC3B-dependent macroautophagy mechanism. Additionally, F1-ispinesib inhibits the proliferation of human aortic smooth muscle cells while enhancing their migration.

MC-Val-Cit-PAB-Ispinesib (Compound 509) is a potent Eg5 inhibitor and a click chemistry reagent [1].

Ispinesib (SB-715992) mesylate is a specific inhibitor of the spindle motor protein KSP, with a Ki app value of 1.7 nM.

AZD-4877 is a potent spindle kinesin (Eg5) inhibitor with an IC50 value of 2 nM. AZD-4877 is an alternative configuration of Ispinesib that inhibits mitosis, induces the formation of a unipolar spindle phenotype, and mediates apoptosis. AZD-4877 has antitumor activity and inhibits circulating peripheral blood mononuclear cells (PBMC).