ind-8

IND8 is a selective and potent α7-nAChR agonist.

XM 412, also known as DMP 450, is an HIV protease inhibitor.

Blonanserin D8 is a deuterium-labeled Blonanserin. Blonanserin (AD-5423) is a dopamine D2/5-HT2 receptor antagonist with an atypical antipsychotic effect.

Teneligliptin D8 a deuterium labeled Teneligliptin (MP-513). Teneligliptin is a potent, orally available, competitive, and long-lasting inhibitor of DPP-4.

Doxazosin D8 (UK 33274 D8) is a deuterium labeled Doxazosin (UK 33274).Doxazosin, a quinazoline derivative, selectively antagonizes postsynaptic AP1 adrenergic receptor.

IND81 is an antiprion agent that works by extending the lives of prion-infected animals.

Busulfan-d8 (Sulphabutin-d8) is a deuterated Busulfan. Busulfan is an effective alkylating anticancer agent with immunosuppressive and myeloablative activities. It exerts anti-cancer activity by crosslinking DNA and causing DNA damage.

Norfloxacin-d8 is a deuterated compound of Norfloxacin. Norfloxacin has a CAS number of 70458-96-7. Norfloxacin(Norxacin) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.

Ofloxacin-d8 is a deuterated compound of Ofloxacin. Ofloxacin has a CAS number of 82419-36-1. Ofloxacin is a fluoroquinolone antibacterial antibiotic. Ofloxacin binds to and inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, enzymes involved in DNA replication and repair, resulting in cell death in sensitive bacterial species.

Levofloxacin-d8 is a deuterated compound of Levofloxacin. Levofloxacin has a CAS number of 100986-85-4. Levofloxacin is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.

Enoxacin-d8 HCl is a deuterated compound of Enoxacin HCl. Enoxacin HCl has a CAS number of 74011-31-7.

Prazosin-d8 hydrochloride is the deuterated form of Prazosin hydrochloride, an α-adrenergic blocker used to treat conditions such as hypertension, anxiety, and panic disorders.

Levofloxacin-d8 (hydrochloride) is the deuterated form of Levofloxacin (hydrochloride).

Marbofloxacin-d8 is the deuterated form of Marbofloxacin, a third-generation fluoroquinolone antibacterial agent with oral activity. It exhibits broad-spectrum bactericidal properties and demonstrates effective therapeutic outcomes. Marbofloxacin is applicable for researching infections caused by both Gram-positive and Gram-negative bacteria, as well as mycoplasma.

Bisdesmethoxy Curcumin-d8 is a deuterated compound of Bisdesmethoxy Curcumin. Bisdesmethoxy Curcumin has a CAS number of 33171-05-0. Bisdemethoxycurcumin (BDMC) is a natural demethoxy derivative of curcumin,with anti-inflammatory and anti-cancer activities.

Ciprofloxacin-d8 is a deuterated compound of Ciprofloxacin. Ciprofloxacin has a CAS number of 85721-33-1. Ciprofloxacin, a synthetic broad spectrum fluoroquinolone antibiotic, inhibits bacterial DNA gyrase. It is more active against Gram-negative bacteria than Gram-positive bacteria.

Prazosin-d8 is a deuterated compound of Prazosin.

Rifampicin-d8 is a deuterium-labelled compound of rifampicin, which can be used for isotope tracing. Rifampicin is a broad-spectrum antibiotic that primarily exerts its antibacterial activity by inhibiting bacterial DNA-dependent RNA polymerase.

Ciprofloxacin-d8 Hydrochloride is a deuterated compound of Ciprofloxacin Hydrochloride. Ciprofloxacin Hydrochloride has a CAS number of 93107-08-5. Ciprofloxacin hydrochloride is a broad-spectrum antimicrobial carboxyfluoroquinoline.

Sarafloxacin-d8 Hydrochloride is a deuterated compound of Sarafloxacin Hydrochloride. Sarafloxacin Hydrochloride has a CAS number of 91296-87-6. Sarafloxacin hydrochloride, a quinolone antibiotic drug, is a hydrochloride salt form of sarafloxacin.

Terazosin-d8 is a deuterated compound of Terazosin. Terazosin has a CAS number of 63590-64-7. Terazosin is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin works by relaxing blood vessels and the opening of the bladder. Terazosin has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment [1] [2] [3].

Ciprofloxacin-d8 Hydrochloride (Standard) is the standard substance of Ciprofloxacin-d8 Hydrochloride, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Ciprofloxacin-d8 Hydrochloride is a deuterated compound of Ciprofloxacin Hydrochloride. Ciprofloxacin Hydrochloride has a CAS number of 93107-08-5. Ciprofloxacin hydrochloride is a broad-spectrum antimicrobial carboxyfluoroquinoline.

3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methicillin-resistant S. aureus (MRSA) and V. vulnificus bacteria (MIC = 31 μg/ml for both).3 It also inhibits HIV-1 integrase in both coupled and strand transfer assays (IC50s = 2.8 and 12.1 μM, respectively).4References1. Kurobane, I., Vining, L.C., McInnes, A.G., et al. 3-Hydroxyterphenyllin, a new metabolite of Aspergillus candidus. Structure elucidation by 1H and 13C nuclear magnetic resonance spectroscopy. J. Antibiot. (Tokyo) 32(6), 559-564 (1979).2. Yen, G.-C., Chang, Y.-C., Sheu, F., et al. Isolation and characterization of antioxidant compounds from Aspergillus candidus broth filtrate. J. Agric. Food Chem. 49(3), 1426-1431 (2001).3. Wang, W., Liao, Y., Tang, C., et al. Cytotoxic and antibacterial compounds from the coral-derived fungus Aspergillus tritici SP2-8-1. Mar. Drugs 15(11), E348 (2017).4. Singh, S.B., Jayasuriya, H., Dewey, R., et al. Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites. J. Ind. Microbiol. Biotechnol. 30(12), 721-731 (2003). 3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methicillin-resistant S. aureus (MRSA) and V. vulnificus bacteria (MIC = 31 μg/ml for both).3 It also inhibits HIV-1 integrase in both coupled and strand transfer assays (IC50s = 2.8 and 12.1 μM, respectively).4 References1. Kurobane, I., Vining, L.C., McInnes, A.G., et al. 3-Hydroxyterphenyllin, a new metabolite of Aspergillus candidus. Structure elucidation by 1H and 13C nuclear magnetic resonance spectroscopy. J. Antibiot. (Tokyo) 32(6), 559-564 (1979).2. Yen, G.-C., Chang, Y.-C., Sheu, F., et al. Isolation and characterization of antioxidant compounds from Aspergillus candidus broth filtrate. J. Agric. Food Chem. 49(3), 1426-1431 (2001).3. Wang, W., Liao, Y., Tang, C., et al. Cytotoxic and antibacterial compounds from the coral-derived fungus Aspergillus tritici SP2-8-1. Mar. Drugs 15(11), E348 (2017).4. Singh, S.B., Jayasuriya, H., Dewey, R., et al. Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites. J. Ind. Microbiol. Biotechnol. 30(12), 721-731 (2003).

2-Methylhexacosane is a saturated hydrocarbon and an insect pheromone. It has been found in the cuticle of M. dasystomus females, but not males, contributing to the mating behavior of males, as well as in D. melanogaster females where it modulates male aggression. 2-Methylhexacosane has also been found in yellow jacket (V. vulgaris) trail extracts.