hpk1

HPK1-IN-19 is an inhibitor of hematopoietic progenitor kinase 1 (HPK1).

HPK1-IN-47, a PROTAC HPK1 degrader (DC 50: 23 nM in PBMCs), serves as a precursor for the synthesis of compounds like PROTAC HPK1 Degrader-2. It is utilized in research focused on diseases mediated by HPK1, including cancer.

HPK1-IN-41 (compound Z389) functions as an HPK1 inhibitor, exhibiting an IC50 value of 0.21 nM [1].

HPK1-IN-12 is a potent inhibitor of HPK1. HPK1-IN-12 has potential for the study of HPK1-related diseases.

HPK1-IN-51, serving as a PROTAC target protein ligand (Ligands for Target Protein for PROTACs), is utilized in synthesis processes.

HPK1-IN-42 (compound 185) is an inhibitor of HPK1, displaying potent activity with an IC50 of 0.24 nM [1].

HPK1-IN-35 is a potent, selective inhibitor of HPK1, demonstrating an IC50 value of 3.5 nM. This compound reduces p-SLP76 expression and facilitates the secretion of IL-2 [1].

HPK1-IN-37 (compound A85) is a potent HPK1 inhibitor with an IC50 value of 3.7 nM, suitable for research on HPK1-associated diseases and disorders, particularly cancers [1].

HPK1-IN-39 (Compound 10n), a selective inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) with an inhibitory concentration (IC50) of 29 nM, impedes the phosphorylation of SLP76. This compound is applicable in the research of cancer immunotherapy [1].

HPK1-IN-11 is a potent HPK1 inhibitor. HPK1-IN-11 has potential for the study of HPK1-related diseases.

HPK1-IN-52 is an effective orally active hematopoietic progenitor kinase 1 (HPK1) inhibitor, displaying anti-tumor activity with an IC50 value of 10.4 nM.

HPK1-IN-49 (Compound I-4) serves as an inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1), exhibiting an IC50 value greater than 100 nM.

HPK1-IN-53 (compound 3a) is the most potent inhibitor of HPK1, exhibiting an IC50 value of 48 nM.

HPK1-IN-38 (compound 15) is an inhibitor of MAP4K1 HPK1, suitable for research into HPK1-related disorders [1].

HPK1-IN-33 (compound 21), a Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor, exhibits a high potency with a K_i of 1.7 nM. It effectively inhibits IL-2 production, demonstrating EC_50 values of 286 nM in Jurkat WT cells and >10000 nM in Jurkat HPK1 KO cells [1].

HPK1-IN-31 inhibitor with an IC 50 value of 0.8 nM. HPK1-IN-31 has anti-tumour activity and has great potential for immunotherapy .

HPK1-IN-29 is a potent inhibitor of hematopoietic progenitor kinase 1 (HPK1), a negative regulator of the activation response of dendritic cells (DCs), T cells, and B cells. HPK1-IN-29 enhances anti-tumor immunity in humans and shows potential for studying immune-related diseases, particularly tumors.

HPK1-IN-27 is a potent inhibitor of HPK1 [MAP4K1, also known as hematopoietic progenitor kinase 1], a member of the germinal center kinase family and a serine threonine kinase, and has shown research potential for cancer diseases.

HPK1-IN-24 (example 51) is a hematopoietic progenitor kinase 1 (HPK1) inhibitor (Ki = 100 nM) with potential applications in cancer research [1].

HPK1-IN-19 is a potent inhibitor of hematopoietic progenitor kinase 1 (HPK1).