free radical scavengers

Edaravone (MCI-186) is a potent new free radical scavenger used for the therapy of patients with acute brain infarction.

AFMK (Formyl-N-acetyl-5-methoxykynurenamine) is a natural product and an apoptosis modulator with antioxidant and free radical scavenging activities. This compound enhances the antitumor effect of gemcitabine in PANC-1 cells and attenuates X-ray-induced oxidative damage to DNA, proteins, and lipids.

Sodium 4-aminosalicylate dihydrate (4-Amino-salicylic acid sodium salt) is the sodium salt form of aminosalicylic acid, an analog of para-aminobenzoic acid (PABA) with antitubercular activity. Sodium 4-aminosalicylate dihydrate exerts its bacteriostatic activity against Mycobacterium tuberculosis by competing with PABA for enzymes involved in folate synthesis, thereby suppressing growth and reproduction of M. tuberculosis, eventually leading to cell death.

Rebamipide (OPC12759) is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis in the gastric mucosa. This agent also inhibits H. pylori-induced production of tumor necrosis factor (TNF) alpha and subsequent inflammation of the gastric mucosa. In addition, rebamipide scavenges oxygen-derived free radicals that potentially cause mucosal injury, and stimulates prostaglandin EP4 receptor gene expression followed by mucous secretion, thereby enhancing the gastric mucosal defense.

Tempo (2,2,6,6-Tetramethylpiperidinooxy) has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin resonance spectroscopy.

Maclurin (NSC-83240) is a phenolic component of mulberry twigs, exerts anti-metastatic effects. Maclurin effectively protects against OH-induced damages to DNA and MSCs and can be used in studies about the prevention of many diseases or MSCs transplantation.

Cycloolivil is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

Isomangiferin has an antiviral effect, may due to their capability of inhibiting virus replication within cells. It also has antioxidant and radical-scavenging activities.

Echinatin (Retrochalcone) is extracted from licorice and is a natural chalcone. Echinatin has a wide range of biological activities including hepatoprotective, anti-inflammatory, anti-bacterial infections, and attenuates lung damage.

Rubiadin (1,3-Dihydroxy-2-Methylanthracene-9,10-Dione) possesses potent antioxidant property, it can prevent lipid peroxidation induced by FeSO4 and t-butylhydroperoxide (t-BHP) in a dose dependent manner.

Peonidin-3-O-glucoside chloride (Peonidin 3-Glucoside Chloride) is an anthocyanin with radical scavenger activity and can be used in studies about acting as an insulin secretagogue.

Retusin is derived from the leaves of Talinum triangulare. Retusin Retusin can be used in studies about acting as pre- and postemergent herbicides.

Cyclo(L-Phe-L-Pro) shows broad-spectrum antibacterial and antifungal activities. Cyclo(L-Phe-L-Pro) exhibits activity against methicillin-resistant S. aureus and Enterococcus raffinosus.

Fullerene-C60 is a potent free radical scavenger with a wide range of bioactivities that can attenuate liver injury and hepatotoxicity, and improve intestinal flora structure and lipid homeostasis.

4'-Methoxyflavonol is a synthetic flavonol with an additional 3-hydroxyl group and higher antioxidant capacity than 4'-Methoxyflavone.4'-Methoxyflavonol interacts with the lipid bilayer of DPPC model membranes, and is capable of scavenging free radicals and antioxidant activity in DPPH assays, and exhibits some antiproliferative activity against K562 and MCF-7 cancer cell lines.

Sorbifolin is a natural flavone glycoside and myeloperoxidase (MPO) inhibitor (IC50=19.2 nM) exhibiting radical scavenging activity.

Bisabolol oxide A is an anti-inflammatory natural product with free radical scavenging activity, exhibiting an IC50 of 1500 mg/L in the DPPH assay.

Dihydroisotanshinone I is a natural product isolated from the dried roots of Salvia miltiorrhiza, a traditional Chinese medicine, and exhibits various biological activities. Dihydroisotanshinone I alleviates menadione-induced liver injury through antioxidant effects such as scavenging free radicals and inhibiting lipid peroxidation; it also inhibits the migration of prostate cancer cells and induces cancer cell apoptosis.

Brassicin is a natural flavonoid exhibiting free radical scavenging activity.

3-p-Coumaroylquinic acid is a natural product exhibiting radical scavenging activity with an EC50 of 189 μM in the DPPH assay.

Uric acid sodium is a potent and widely recognized antioxidant with the ability to scavenge oxygen free radicals, helping to maintain blood pressure stability and counteract oxidative stress. It effectively eliminates reactive oxygen species (ROS), such as singlet oxygen and peroxynitrite, and inhibits lipid peroxidation. Additionally, uric acid sodium is closely associated with the pathogenesis of gouty arthritis and the formation of calcium oxalate stones, and it can be used to induce hypertension models.

Kuromanin chloride (Chrysontemin chloride) is potent antioxidants and free radical scavengers, may act as modulators of gene regulation and signal transduction pathways.

Kuromanin chloride (Standard) is a reference standard for research and analysis in studies involving Kuromanin chloride. Kuromanin chloride (Chrysontemin chloride) is potent antioxidants and free radical scavengers, may act as modulators of gene regulation and signal transduction pathways.