fas/fasl

Araloside A (Chikusetsusaponin IV) might relieve cutaneous symptoms caused by excessive apoptotic cell death in the skin through the Fas/FasL pathway.

Kp7-6 is a Fas mimetic peptide that disrupts receptor complexes by simultaneously binding to Fas and FasL, thereby blocking downstream apoptotic signaling. Kp7-6 inhibits ERK1-2 phosphorylation, induces IκBα phosphorylation, and activates NF-κB. Kp7-6 suppresses the activation of caspase-8, caspase-3, and JNK, reduces human amylin-induced β-cell apoptosis, and decreases FasL-mediated lymphocyte cytotoxicity and apoptosis. In pancreatic neuroendocrine tumor models, Kp7-6 downregulates local FasL expression, increases CD8+Fas+ T-cell infiltration, and reduces tumor volume. Kp7-6 prevents concanavalin A-induced liver injury in mice and is applicable to research on type 2 diabetes, hepatitis, and pancreatic neuroendocrine tumors.

KR-33493 is a FAS-associated factor 1 (FAF1) inhibitor and can be used in studies about Parkinson's disease.

Marginatoxin may be a promising chemopreventive agent for treating hepatocellular carcinoma, it induces human hepatoma BEL-7402 cells apoptosis in vitro and in vivo via activation of Fas/FasL-mediated apoptotic pathway.

PaPE-1 is a pathway-preferential estrogen that activates extracellular nuclear signaling pathways without affecting nuclear signaling pathways. It exerts anti-apoptotic effects by inhibiting Aβ-induced caspase activity and reducing chromatin condensation associated with apoptosis, thereby preventing neuronal cell death. Additionally, post-treatment with PaPE-1 decreases the mRNA expression of apoptosis-specific factors (such as Bax, Gsk3b, Fas, and Fasl) under Aβ influence, while upregulating Bcl2 expression.

Fenvalerate (Evercide 2362) is a inhibitor of protein phosphatase 2B (calcineurin), a synthetic pyrethroid insecticide, and inhibits PP2B-Aα.High doses of Fenvalerate impair cognitive and behavioral development.Fenvalerate induces, through the Fas/FasL signaling pathway, the induction of Fenvalerate induces germ cell apoptosis in mouse testis through the Fas/FasL signaling pathway.

(Rac)-Indoximod (1-Methyl-DL-tryptophan) is a potent inhibitor of indoleamine 2,3-dioxygenase (IDO). Combined treatment with IFN-γ and (Rac)-Indoximod significantly suppresses the activity of α-SMA-expressing human cardiac myofibroblasts (hCMs) and promotes apoptosis by up-regulating the genes IRF-1, Fas, and FasL, effectively improving cardiac fibrosis[1].

Fenvalerate (Standard) is the standard substance of Fenvalerate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Fenvalerate (Evercide 2362) is a inhibitor of protein phosphatase 2B (calcineurin), a synthetic pyrethroid insecticide, and inhibits PP2B-Aα.High doses of Fenvalerate impair cognitive and behavioral development.Fenvalerate induces, through the Fas/FasL signaling pathway, the induction of Fenvalerate induces germ cell apoptosis in mouse testis through the Fas/FasL signaling pathway.

Araloside A (Standard) is a reference standard for research and analysis in studies involving Araloside A. Araloside A (Chikusetsusaponin IV) might relieve cutaneous symptoms caused by excessive apoptotic cell death in the skin through the Fas/FasL pathway.

IP3RCYT is an inhibitory peptide of IP3R that can prevent cytochrome C from binding with IP3R, with an IC50 of approximately 100 nM. It regulates intracellular calcium signaling. Additionally, IP3RCYT inhibits apoptosis in HeLa and Jurkat cells treated with staurosporine or membrane-bound Fas ligand (FasL).