eoc

EOC317 (ACTB-1003) is an oral kinase inhibitor with IC50 values of 6 nM, 2 nM, and 4 nM for FGFR1, VEGFR2, and Tie-2, respectively.

Songorine (Napellonine) shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.

Ortho-methyl 4-AP-1-ethyl Carbamate is used as a precursor for the synthesis of ortho-methylfentanyl.

Neocuproine is a copper(I) chelator that enhances the purinergic component of vasoconstriction induced by electric field stimulation, and is often used as a ligand reagent and copper ion detector.Neocuproine forms stable complexes with copper ions and can play a catalytic role in certain chemical reactions and analytical methods.Neocuproine acts as a redox-active on the iron and cobalt ligand platform for protection against oxidative damage in NSC34 cells.

Neochlorogenin is a useful organic compound for research related to life sciences and the catalog number is T124737.

Oleocanthal is a useful organic compound for research related to life sciences and the catalog number is T125114.

Neocryptomerin is a useful organic compound for research related to life sciences and the catalog number is T125374.

Citreochlorol is a useful organic compound for research related to life sciences. The catalog number is T126006 and the CAS number is 135352-11-3.

9,10-Methyleneoctadecanoic acid is a useful organic compound for research related to life sciences and the catalog number is T128733.

Neocarzinostatin is an effective DNA-damaging, anti-tumor antibiotic. It recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin leads to apoptosis. Neocarzinostatin has potential for EpCAM-positive cancer treatment.

Nucleocidin, an antitrypanosomal antibiotic, inhibits the transfer of labeled amino acids from S-RNA to protein.

Seocalcitol is an analog of vitamin D, binds vitamin D receptor protein from human osteosarcoma MG-63 cells(Kd : 0.27 nM).

Neocryptolepine-Cl (compound Z24) is an inhibitor of Bcthi4, demonstrating excellent antifungal activity against B. cinerea, with an EC50 value of 0.56 μg/mL.

Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone. Secretion of osteocalcin (1-49) is stimulated by 1,25-dihydroxy vitamin D and plasma levels increase in diseases that induce dysregulated bone turnover such as osteoporosis, Paget's disease, and primary hyperparathyroidism. Osteocalcin (1-49) is positively correlated with insulin sensitivity and negatively correlated with high blood glucose levels in women. In vitro, osteocalcin induces chemotaxis of MDA-MB-231 breast cancer cells, human peripheral blood monocytes, and rat osteosarcoma cells with osteoblast-like characteristics. It is also expressed by vascular smooth muscle cells (VSMCs) displaying an osteoblast-like phenotype and has been positively associated with calcification of aortic tissue and heart valves in humans.

cis-9,10-Methyleneoctadecanoic acid is a cyclopropane fatty acid found in bacteria and the digestive gland of P. globosa, forming a component of S. aureus cell membranes with levels that decrease upon treatment with carvacrol. Secreted by H. pylori, it enhances histamine- and dibutyryl cAMP-stimulated acid secretion in isolated guinea pig parietal cells and activates protein kinase C (PKC) in a calcium-dependent manner.

(S)-4-Methyl-2-(methyl((2-(trimethylsilyl)ethoxy)carbonyl)amino)pentanoic acid is a useful organic compound for research related to life sciences. The catalog number is T64785 and the CAS number is 2411590-92-4.

Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) is an antioxidant compound used in the treatment of oxidative stress and related afflictions.

Phaeocaulisin E (Compound 5), a guaiane-type sesquiterpene, inhibits LPS-induced NO production in RAW 264.7 macrophages, exhibiting an IC50 value of 10.3 µM [1].

Neocucurbitacin A (compound 7), a STAT3 inhibitor extracted from the pericarp of Aquilaria crassna, serves as a potential agent for anticancer research [1].

Neochilenin (3-O-Methylquercetin 4'-O-glucoside) is a glycoside derivative of 3-O-methylquercetin that is extractable from the sub-family Cereoideae of the Cactaceae family. [1]

Leocarpinolide F, a sesquiterpenoid naturally derived from Siegesbeckia orientalis [1], exhibits an ability to inhibit (anti-feedant) and demonstrates significant insecticidal activity (toxicity) against plant herbivore pests such as Spodoptera littoralis larvae.

(2E)-Leocarpinolide F (Compound 20), a germacrane-type sesquiterpenoid, is isolated from Sigesbeckia orientalis [1].

Cis-9,10-Methyleneoctadecanoic acid methyl ester, a cyclopropane fatty acid methyl ester, stimulates DNA synthesis in rat hepatocytes and serves as a standard for quantifying cis-9,10-methyleneoctadecanoic acid in bacterial membranes through co-chromatography. [Matreya, LLC. Catalog No. 1823]

Teleocidin B-4 serves as a PKC activator, enhancing the accumulation of HIF-1α protein through the PKCα/mTORC signaling pathway and upregulating hypoxia-inducible factor 1 (HIF-1) activity. This compound is useful for cancer-related research.