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Results for "

e3 ligase ligand 1

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    212
    TargetMol | Inhibitors_Agonists
  • PROTAC Products
    206
    TargetMol | PROTAC
(S,R,S)-AHPC-Me hydrochloride
VHL ligand 2 hydrochloride, E3 ligase Ligand 1
T136711948273-03-7
(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is utilized in the synthesis of ARV-771, a potent BET protein degrader. It selectively degrades BET protein in castration-resistant cells with a DC50 <1 nM. Recognized as VHL ligand 2 hydrochloride, it serves as the VHL ligand from (S,R,S)-AHPC for recruiting von Hippel-Lindau (VHL) protein.
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E3 ligase Ligand 10
T178681073560-68-5
E3 ligase Ligand 10 serves as a ligand for E3 ubiquitin ligase and can be conjugated to a protein ligand through a linker, resulting in the formation of PROTACs. These PROTACs act as inducers of ubiquitination-mediated degradation, specifically targeting cancer-promoting proteins[1].
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7-10 days
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E3 ligase Ligand 13
T17871
E3 ligase Ligand 13 is an E3 ubiquitin ligase ligand that can be employed to create PROTACs, which are connected to the ligand for the protein through a linker. PROTACs serve as inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
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E3 ligase Ligand 14
T178722241489-43-8
E3 ligase Ligand 14 binds to E3 ubiquitin ligase and, when conjugated to a protein ligand via a linker, forms PROTACs that facilitate the ubiquitination-mediated degradation of cancer-promoting proteins[1].
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E3 ligase Ligand 18
T178762241669-88-3
E3 ligase Ligand 18 is a compound that binds to E3 ubiquitin ligase and can be chemically linked to a protein ligand via a linker to form PROTACs, which induce ubiquitination-mediated degradation of cancer-promoting proteins [1].
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(S,R,S)-AHPC hydrochloride
VHL Ligand 1 hydrochloride, ULM-1, Protein degrader 1 hydrochloride
T42071448189-80-7
(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs).
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Thalidomide 4-fluoride
E3 ligase Ligand 4
T7755835616-60-9
Thalidomide 4-fluoride (E3 ligase Ligand 4) (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand. Thalidomide 4-fluoride can be used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.
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(S,R,S)-AHPC
VH032-NH2, MDK7526, VHL ligand 1
T84121448297-52-6
(S,R,S)-AHPC (VH032-NH2) is a VH032-based ligand for recruiting the von Hippel-Lindau (VHL) protein, potentially useful for the targeted degradation of the androgen receptor.
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AR antagonist 1
T103591818885-54-9
AR antagonist 1 is a potent antagonist of the androgen receptor. It binds to E3 ligase ligands with weak binding affinities to VHL protein in the synthesis of PROTAC ARD-266.
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Thalidomide-O-amido-C6-NH2 TFA
E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate, Cereblon Ligand-Linker Conjugates 11 TFA, E3 Ligase Ligand-Linker Conjugates 25 TFA
T179191950635-14-9
Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA) is a synthesized E3 ligase ligand-linker conjugate comprising a Thalidomide-based cereblon ligand and a linker.
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(S,R,S)-AHPC TFA
VH032-NH2 TFA, VHL ligand 1 TFA
T179271631137-51-3
(S,R,S)-AHPC TFA (VHL ligand 1 TFA) (VH032-NH2 TFA) is a VH032-based ligand designed for von Hippel-Lindau (VHL) protein recruitment. This compound can be linked to protein ligands (e.g., BCR-ABL1) using a linker to create PROTACs (e.g., GMB-475), which effectively induce the degradation of BCR-ABL1, demonstrated by an IC50 of 1.11 μM in Ba F3 cells.
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Thalidomide-O-amido-C6-NH2 hydrochloride
T188162376990-31-5
Thalidomide-O-amido-C6-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate, integrating a Thalidomide-based cereblon ligand with a linker, suitable for PROTAC synthesis.
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Thalidomide-O-amido-PEG-C2-NH2 hydrochloride
T188182204226-02-6
Thalidomide-O-amido-PEG-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate, incorporating a Thalidomide-based cereblon ligand and a linker. This compound is used in the synthesis of PROTACs.
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Thalidomide-O-amido-C3-NH2 TFA
Cereblon Ligand-Linker Conjugates 16 TFA, E3 Ligase Ligand-Linker Conjugates 52 TFA
T77602022182-58-5
Thalidomide-O-amido-C3-NH2 TFA (Cereblon Ligand-Linker Conjugates 16 TFA) is a synthesized E3 ligase ligand-linker conjugate incorporating a Thalidomide-based cereblon ligand and a linker used in PROTAC technology.
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Pomalidomide-C2-NH2 hydrochloride
T77612305369-00-8
Pomalidomide-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate incorporating the Pomalidomide-based cereblon ligand and a linker used in [PROTAC] technology.
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CRBN modulator-1
WUN29654
T88242407829-65-4
CRBN modulator-1 (WUN29654) is a Thalidomide analog and CRBN modulator,has an IC50 of 3.5 μM and a Ki of 0.98 μM.
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Thalidomide-NH-C2-PEG3-OH
H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-
T93822140807-23-2
Thalidomide-NH-C2-PEG3-OH (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-) is an E3 ligase ligand-linker conjugate.
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Thalidomide-PEG4-Propargyl
Thalidomide-O-PEG4-Propargyl
T93892098799-77-8
Thalidomide-PEG4-Propargyl (Thalidomide-O-PEG4-Propargyl) is a synthetic E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker which can be used in PROTAC technology[1].
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Eragidomide
CC-90009, Cereblon modulator 1
T107651860875-51-9
Dicyclanil is an insect growth regulator with a chemical structure similar to that of cyclopromazine.
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(S,R,S)-AHPC-Me dihydrochloride
VHL ligand 2 dihydrochloride, E3 ligase Ligand 1 dihydrochloride, (S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base)
T13671L
(S,R,S)-AHPC-Me dihydrochloride, also known as VHL ligand 2 dihydrochloride, is a chemical compound used in the synthesis of ARV-771. ARV-771 is a BET PROTAC degrader that relies on von Hippel-Landau (VHL) E3 ligase and exhibits potent degradation of BET proteins in castration-resistant prostate cancer (CRPC) cells, with a DC50 of less than 1 nM. This compound acts as the VHL ligand, specifically the (S,R,S)-AHPC-based VHL ligand, facilitating the recruitment of von Hippel-Lindau (VHL) protein.
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MAK683-CH2CH2COOH
T137652639882-68-9
MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein) and, together with a VHL ligand for the E3 ubiquitin ligase, has been used to design EED-Targeted PROTACs, specifically EED degrader-1 and PROTAC EED degrader-2 [1].
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8-10 weeks
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PROTAC IRAK4 degrader-1
T138422360533-90-8
PROTAC IRAK4 degrader-1 (compound I-210) is a Cereblon based PROTAC consisting of the PROTAC IRAK4 ligand-1, the E3 ligase ligand Pomalidomide and the PROTAC linker AM-Imidazole-PA-Boc.
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VHL Ligand 8
T139582701565-76-4
VHL Ligand 8, a VHL ligand essential for synthesizing ARD-266, acts as a highly potent VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. It efficiently facilitates the degradation of AR protein in AR-positive prostate cancer cell lines LNCaP, VCaP, and 22Rv1, exhibiting DC50 values ranging from 0.2-1 nM [1].
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10-14 weeks
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PROTAC Sirt2 Degrader-1
T166672098487-75-1
PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC that acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1 Sirt3 (IC50s > 100 μM)[1].
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