dsrna

Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MDA5).

TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cells.

Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic double-stranded RNA (dsRNA) analog and an agonist of TLR3 as well as retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5). It can induce innate immune responses in mammals and serve as a vaccine adjuvant to enhance both innate and adaptive immunity, while modulating the tumor microenvironment and directly inducing apoptosis in cancer cells. Poly(I:C) is commonly used to establish acute respiratory distress syndrome (ARDS) animal models for studying immune responses and disease mechanisms.

HCoV-229E-IN-1 is a potent inhibitor of HCoV-229E replication, demonstrating efficacy with EC50 values of 0.65 μM in MTS cells and 0.6 μM in CPE cells[1].

Nedosiran (DCR-PHXC) is a GalNAc-dsRNA conjugate designed for RNA interference–based silencing of lactate dehydrogenase (LDH), enabling selective hepatic targeting and reduction of oxalate production, Nedosiran is extensively studied as a potential therapeutic approach for patients with primary hyperoxaluria and end-stage renal disease to address metabolic dysregulation at the RNA level.

Poly(I:C):Kanamycin (1:1) is an equimolar mixture of Poly(I:C) and kanamycin. Poly(I:C) is a synthetic double-stranded RNA analogue and TLR3 agonist commonly used as a vaccine adjuvant; kanamycin enhances Poly(I:C) stability.

Nedosiran sodium, a GalNAc-dsRNA conjugate, is engineered to suppress the synthesis of the hepatic lactate dehydrogenase (LDH) enzyme.

Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effects, it also has anti-inflammatory properties related with its inhibition of NO, cytokines,chemokines, and growth factors in dsRNA-stimulated macrophages via the calcium pathway. Myristicin can induce Apoptosis as characterised by alterations in the mitochondrial membrane potential, cytochrome c release, Caspase-3 activation, PARP-cleavage and DNA fragmentation.

Anti-TLR3/CD283 Antibody (CNTO5429) is a potent neutralizing antibody targeting human Toll-like receptor 3 (TLR3), acting by interfering with the binding of double-stranded RNA (dsRNA) to the receptor's extracellular domain. The compound is an essential tool for investigating immune responses induced by endogenous or viral dsRNA, aiming to downregulate the production of pro-inflammatory cytokines by blocking the TLR3 signaling pathway.

Myristicin (Standard) is a reference standard for research and analysis in studies involving Myristicin. Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effects, it also has anti-inflammatory properties related with its inhibition of NO, cytokines,chemokines, and growth factors in dsRNA-stimulated macrophages via the calcium pathway. Myristicin can induce Apoptosis as characterised by alterations in the mitochondrial membrane potential, cytochrome c release, Caspase-3 activation, PARP-cleavage and DNA fragmentation.

E.coli tRNA adenosine deaminase is derived from Escherichia coli and functions as an adenosine deaminase. It effectively deaminates adenine within single-stranded RNA (ssRNA, primarily in the loop regions of tRNA) or double-stranded RNA (dsRNA) but lacks deaminase activity on DNA. This enzyme is a protein-engineered mutant form of adenosine deaminase, efficiently deaminating adenine in ssDNA, making it useful for adenine base editing (ABE) and RNA m6A methylation sequencing.