dmf

Dimethyl fumarate (DMF) is an Nrf2 activator with oral activity and blood-brain barrier permeability. Dimethyl fumarate has antimicrobial, anti-inflammatory, and immunomodulatory activities and has been used in the study of multiple sclerosis.

Monomethyl fumarate is a potent agonist of GPR109A .

DMT-dG(dmf) Phosphoramidite is a phosphinamide monomer used in oligonucleotide synthesis.

5'-O-DMT-2'-O-TBDMS-rI, a modified nucleoside, is utilized in deoxyribonucleic acid (DNA) or nucleic acid synthesis.

3,7-Dimethylfumarate (3,7-DMF) serves as an oral inhibitor of transforming growth factor-beta 1 (TGF-β1)-mediated hepatic stellate cell (HSC) activation. By inducing antioxidant gene expression and scavenging reactive oxygen species (ROS), 3,7-DMF is useful for researching liver fibrosis [1].

Pesticides Mix-10 in Acetonitrile containing 5% DMF (Standard) is a standard material used for research and analysis of pesticides.

N2-DMF-2'-O-Methylguanosine is a monomer used in nucleic acid synthesis.

5'-O-DMTr-2'-O-4'-C-Locked-rG(dmf) is a monomeric precursor utilized in nucleic acid synthesis.

DMTr-2'-ara-F-dG(dmf)-3'-CE-Phosphoramidite is a monomer material utilized in nucleic acid synthesis.

DMTr-dA(dmf)-3'-CE-Phosphoramidite is a monomeric material utilized in nucleic acid synthesis.

Dmf-dg (2'-Deoxy-N2-dimethylaminomethylene-guanosine) is a nucleoside of deoxyguanosine (dG) with a dimethylaminomethylene (DMF) base protection, employed in the synthesis of oligonucleotides.

3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite serves as a precursor of adenosine nucleotide monomers used in the solid-phase synthesis of oligonucleotides, particularly for modifying oligonucleotides such as terminally modified DNA strands. It features Trityl (Tr), Cyanoethyl (CE), and Dimethylformamidine (DMF) protective groups, classifying it as a ddNTP adenosine nucleoside suitable for applications like oligonucleotide solid-phase synthesis, probe design, and chain termination sequencing.

2'-OMe-8-Me-DMF-G Phosphoramidite is a phosphoramidite compound that includes modified guanine (G) and a dimethoxytrityl (DMT) group. This compound is utilized in the synthesis of RNA oligonucleotides.

Dimethyl fumarate-D6 is a deuterium labeled Dimethyl fumarate (T0492). can induces upregulation of antioxidant gene expression.

Furanones (HDMF) are mainly derived from American grape (Vitis labrusca) and its hybrid varieties. As an important aroma compound in fruits, it exhibits strawberry-like aroma characteristics in some wines.

Duocarmycin DM free base is a potent DNA alkylator and antitumor antibiotic. It induces DNA damage via sequence-specific alkylation in the minor groove, commonly used as an ADC payload in cancer research.

Isocyanic acid, m-(fluorosulfonyl)phenyl ester is a bioactive chemical.

Ganoderic acid Mf, an antitumor triterpenoid, selectively induces apoptosis in cancer cells through a mitochondria-mediated pathway while demonstrating high selectivity between normal and cancer cells. It also arrests the cell cycle in the G1 phase [1].

GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.

SHP2-IN-38 is an innovative green fluorescent inhibitor targeting SHP2, exhibiting IC50 values as follows: 2.89 μM (SHP2), 8.73 μM (SHP1), 11.08 μM (PTP1B), and 33.07 μM (TCPTP). It impedes the SHP2-mediated ERK signaling pathway and inhibits MV4-11 cell proliferation in vitro with an IC50 of 7.90 μM. The excitation wavelength of SHP2-IN-38 is 360 nm, with a maximum emission wavelength of 550 nm in DMSO and 540 nm in DMF. Additionally, it demonstrates green fluorescent imaging in HeLa cells and zebrafish.

Monomethyl fumarate-D2 is the deuterated form of Monomethyl fumarate, which is an active metabolite of Dimethyl fumarate (DMF) and serves as an effective GPR109A agonist. Monomethyl fumarate (T12095) holds potential in various neuroprotective pathways and models of other retinal diseases.

Fmoc-Phe-OH is a highly hydrophobic Fmoc-protected phenylalanine derivative that dissolves well in DMF and NMP, with analogs available for structure-activity relationship (SAR) and drug optimization studies, making Fmoc-Phe-OH suitable for peptide synthesis and chemical biology research.

NOTP is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic NOTA derivative designed for tumor pretargeting. It is suitable for conjugation with peptides and radionuclides.

N-Acetyl-S-(N-methylcarbamoyl) cysteine is a metabolite of the solvent N,N-dimethylformamide (DMF) and can be utilized to monitor industrial exposure.