dbco-peg-1

DBCO-PEG1, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG1-acid is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG1-amine is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, and facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG1-NH-Boc is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG1-NHS ester is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands necessary for PROTAC molecule formation. This linker enables selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

DBCO-PEG10-DBCO is a PEG-based linker used in PROTACs, joining two essential ligands needed to form PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG12-acid is a PEG-based linker for PROTACs that connects two essential ligands, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

DBCO-PEG12-NHS ester is a PEG-based PROTAC linker for synthesising PROTAC molecules, whose DBCO group undergoes click chemistry with azide-containing molecules.

DBCO-PEG13-DBCO, a PEG-based linker for PROTACs, connects two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG13-NHS ester is a PEG-type PROTAC linker useful in the synthesis of PROTAC molecules. This compound acts as a click chemistry reagent and contains a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group.

DBCO-PEG2-C2-acid, serving as an ADC Linker, is utilized in the synthesis of Antibody-Drug Conjugates (ADCs).

DBCO-PEG16-NHS ester is a PEG derivative composed of DBCO, PEG units, and an NHS ester. The NHS ester can react with amino acids or other amine-containing molecules. The DBCO group in DBCO-PEG16-NHS ester can engage in a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with azide-containing molecules.

Azido-PEG7-amine is a non-cleavable ADC linker and PEG-based PROTAC linker that can be used to synthesise antibody-drug conjugates (ADCs) and PROTACs. It can undergo click chemistry reactions with molecules containing alkyne, DBCO or BCN groups.

DBCO-acid is utilized in the synthesis of ADC linker DBCO-NHS ester and drug-linker conjugates DBCO-PEG-MMAE[1].

DBCO-NHCO-PEG4-NHS ester is a DBCO-containing PEGylated active ester linker that combines NHS ester reactivity toward primary amines with strain-promoted azide-alkyne cycloaddition capability. It enables efficient bioconjugation through amide coupling and copper-free click reaction with azide groups. The PEG4 spacer provides hydrophilicity and tunable linker length, making it widely used in PROTAC and antibody-drug conjugate (ADC) construction.

DBCO-NHCO-PEG5-NHS ester is a polyethylene glycol (PEG)-based linker used in the synthesis of PROTACs [1].

DBCO-PEG4-Maleimide is a non-cleavable PEG-based linker used in the synthesis of antibody–drug conjugates (ADCs). DBCO-PEG4-Maleimide contains a dibenzocyclooctyne group, which enables strain-promoted alkyne–azide cycloaddition (SPAAC) with azide-functionalized biomolecules, supporting efficient construction of bioconjugates under copper-free click conditions.

DBCO-PEG4-NHS ester is a PEG-based PROTAC linker utilized in PROTAC synthesis[1].

PC Biotin-PEG3-azide is a cleavable ADC linker containing three PEG units, which can be used for the synthesis of antibody-drug conjugates (ADCs). PC Biotin-PEG3-azide belongs to click chemistry reagents. Its azide group can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

N3-PEG4-C2-NH2 is a PEG-type PROTAC linker that can be used in the synthesis of PROTAC molecules .This compound is a click chemistry reagent containing an Azide group.It can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing an Alkyne group,and can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

APN-PEG4-DBCO is a cleavable linker for antibody-drug conjugates (ADCs), consisting of a four-unit PEG and a DBCO moiety, used in ADC synthesis[1].

Carboxyrhodamine 110-PEG4-DBCO is a PEG-based PROTAC linker used in PROTAC synthesis [1].

DBCO-C-PEG1 is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, facilitating selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

DBCO-NH-PEG7-C2-NHS ester is a polyethylene glycol (PEG) derived linker with a terminal DBCO moiety, functioning as an N-hydroxysuccinimide (NHS) ester, and suitable for the efficient synthesis of proteolysis-targeting chimeras (PROTACs)[1].