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Results for "

crth2 antagonist 2

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    5718
    TargetMol | Activity
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    436
    TargetMol | inventory
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    4
    TargetMol | natural
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CRTh2 antagonist 2
T10889780763-95-3In house
CRTh2 antagonist 2 is a selective and potent CRTH2 antagonist, IC50≤10 nM. CRTh2 antagonist 2 can be used to study the direction of androgenic alopecia.
  • $109
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CRTh2 antagonist 3
T10890312928-72-6
CRTh2 antagonist 3 is a powerful chemokine receptor homologous molecule expressed on Th2 cell (CRTh2) antagonists. CRTh2 antagonist 3 enhanced the activity of PDK1 on short peptide substrates with EC50 of 2 μM and Kd of 8.4 μM. CRTh2 antagonist 3 has the
    Inquiry
    2-Deoxy-D-glucose
    T6742154-17-6
    2-Deoxy-D-glucose (2-DG) is an analog of glucose, an inhibitor of glycolysis. 2-Deoxy-D-glucose has antiviral activity, as well as inhibitory cell proliferation and apoptosis-inducing activity.
    • $33
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    TargetMol | Inhibitor Hot
    TargetMol | Citations Cited
    MSA-2
    T8798129425-81-6
    MSA-2 is an orally available non-nucleotide STING agonist. The non-covalent dimer of MSA-2 binds to STING with nanomolar affinity. It shows anti-tumor activity in syngeneic mouse tumor models, synergizes with anti-PD-1, stimulates tumor secretion of interferon-β, induces tumor regression, and has long-lasting anti-tumor immunity. [3]
    • $34
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    Tirzepatide Acetate(2023788-19-2 free base)
    TP1111L
    Tirzepatide (LY3298176) Acetate (2023788-19-2 free base) is a new molecule that can control blood glucose levels by combining dual agonism of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors.[3]
    • $358
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    TargetMol | Inhibitor Hot
    2',3'-cGAMP sodium
    T10065L2734858-36-5In house
    2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a second messenger in cellular innate immunity, catalyzed by cGAMP synthase (cGAS) under DNA binding conditions. It binds to STING to form a dimer, inducing the production and expression of interferon-β and other cytokines.
    • $298
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    TargetMol | Inhibitor Hot
    Rel-5-(4-Chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-tetrahydro-2-(1-methyl-1H-pyrazol-4-yl)-2H-pyran-4-yl]pyrido[3,4-b]pyrazine
    T62750L2738485-99-7In house
    rel-5-(4-Chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-tetrahydro-2-(1-methyl-1H-pyrazol-4-yl)-2H-pyran-4-yl]pyrido[3,4-b] The EC50 value of pyrazine against TREM2 was ≤ 0.05 μM and the E.max value was > 250 μM.
    • $320
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    TREM2 agonist-2
    T627502738485-98-6In house
    TREM2 agonist-2 (I-192) is an orally active and potent agonist of myeloid triggered receptor 2 (TREM2) for neurodegenerative disease research.
    • $283 TargetMol
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    Methyl 3-[2-[[(4R)-4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl]methylamino]ethyl]benzoate
    T15257L2725484-87-5In house
    Methyl 3-[2-[[(4R)-4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl]methylamino]ethyl]benzoate is a biochemical reagent that can be used to synthesize active compounds.
    • $195
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    Bis(2-methoxy-5-((Z)-3,4,5-trimethoxystyryl)phenyl) hydrogen phosphate
    T67906735261-22-0In house
    Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-, 1,1'-(hydrogen phosphate) is a chemical compound that is a phosphate derivative of the statin class.
    • $60
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    PARP-2-IN-3
    T730272915650-86-9In house
    PARP-2-IN-3 is used as a potent PARP-2 inhibitor (IC50=0.07 μM) with anti-tumor activity that induces apoptosis and necrosis in cancer cells, and can be used for the study of breast cancer.CAS 번호128-52-56-8
    • $350 TargetMol
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    MIF-IN-2
    T608502756410-57-6In house
    MIF-IN-2 is a heterocyclic macrophage migration inhibitory factor (MIF) inhibitor with anticancer activity for the study of cancer and autoimmune disorders.CAS 번호13460-73-86-5
    • $293 TargetMol
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    4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine
    T601262649012-21-3In house
    4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine is an enantiomeric counterpart of SSR-125543. SSR-125543 is a potent CRF-R1 antagonist with Ki = 1.0 nM for human CRF-R1.
    • $117
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    CFM-2
    T10774178616-26-7In house
    CFM-2, a potent and selective non-competitive antagonist of AMPAR (AMPAR), exhibits anticonvulsant activity across various seizure models.
    • $54
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    dMCL1-2
    T136572351218-88-5In house
    dMCL1-2 is a potent and selective myeloid leukemia 1 (MCL1) degrading agent based on PROTAC, binding to MCL1 with a KD of 30 nM and activating the apoptosis mechanism by degrading MCL1.
    • $3,200
    3-6 months
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    hBChE-IN-2
    T775092923366-36-1In house
    hBChE-IN-2 is a butyrylcholinesterase (BChE) inhibitor and cannabinoid receptor 2 (CB2R) agonist with neuroprotective activity for the study of Alzheimer's disease-like neurological disorders.
    • $195 TargetMol
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    6-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-1H-pyridine-3,4-dicarbonitrile
    T643931314134-92-3In house
    6-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-1H-pyridine-3,4-dicarbonitrile is a biologically active compound, which is utilized for research in the fields of chemistry and life sciences.
    • $117
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    1-(2-fluorophenyl)-3-[5-(2-methoxyphenyl)
    T67696426242-86-6In house
    1-(2-fluorophenyl)-3-[5-(2-methoxyphenyl)-1,3,4-thiadiazol-2-yl]urea is a chemical compound.
    • $197
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    Cot inhibitor-2
    T10866915363-56-3In house
    Cot inhibitor-2 is a cot (Tpl2/MAP3K8) inhibitor (IC50: 1.6 nM) with potency, selectivity and oral activity. cot inhibitor-2 inhibits LPS-stimulated TNF-α production in human whole blood with an IC50 of 0.3 μM.
    • $93
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    (S)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-2-(pyrimidin-5-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide
    T601861934246-20-4In house
    MitoBloCK-6 is an effective inhibitor of Erv1/ALR with IC50 values of 900 nM and 700 nM, respectively. Additionally, MitoBloCK-6 inhibits Erv2 (IC50=1.4 μM). It induces apoptosis in hESCs by promoting the release of cytochrome c.
    • $117
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    IMPDH2-IN-2
    T623381434517-02-8In house
    IMPDH2-IN-2 is a potent inhibitor of inosine 5'-monophosphate dehydrogenase (IMPDH) (Ki,app: 14 μM) and a potential anti-tuberculosis agent, exhibiting moderate antibacterial effects with MIC values of 6.3 and 11 μM in minimal GAST Fe and rich 7H9 ADC Tween media, respectively.
    • $100 TargetMol
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    (Z)-2-fluoro-1,3-bis(4-methoxyphenyl)prop-2-en-1-one
    T85319126912-62-7In house
    (Z)-2-fluoro-1,3-bis(4-methoxyphenyl)prop-2-en-1-one is a screening compound and can be used in new drug development related research.
      Inquiry
      ERK1/2 inhibitor 1
      T112262095719-90-5In house
      ERK1 2 inhibitor 1 is a potent, orally bioavailable compound that exhibits 60% inhibition at 1 nM and has an IC50 of 3.0 nM against ERK1 and ERK2, respectively.
      • $128
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      CB2 receptor agonist 2
      T220091314230-75-5In house
      CB2 receptor agonist 2 (ZINC72105556) is a potent and selective agonist for the CB2 (cannabinoid type 2) receptor, Ki = 8.5 nM. CB2 receptor agonist 2 has high affinity and selectivity for CB2.
      • $118
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      VEGFR-2-IN-9
      T10123408502-06-7In house
      VEGFR-2-IN-9 (KDR-in-4) is a potent KDR VEGFR2 inhibitor with an IC50 of 7 nM, suitable for breast cancer research.
      • $700
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      Helioxanthin derivative 5-4-2
      T11550203935-39-1In house
      Helioxanthin derivative 5-4-2 (Helioxanthin 5-4-2) is an analogue of helioxanthin that shows anti-HBV activity in vitro and can be used to study HBV.
      • $197 TargetMol
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      Cdk1/2 Inhibitor III
      T14914443798-55-8In house
      Cdk1 2 Inhibitor III is a selective inhibitor of Cdk1 2 with an IC50 value of 2.1 μM against CDK1 cyclin B.
      • $350
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      SARS-CoV-2-IN-38
      T789612882823-27-8In house
      SARS-CoV-2-IN-38 is an orally available SARS-CoV-2 inhibitor with potential antiviral activity for the study of SARS viral infections.
      • $293 TargetMol
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      N′-(2-Chloroethyl)-N-(4-methylcyclohexyl)-N-nitrosourea
      T7359275219-93-1In house
      N′-(2-Chloroethyl)-N-(4-methylcyclohexyl)-N-nitrosourea has antitumor activity and is used in the treatment of Lewis lung and colon tumors.
      • $195
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      Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)-
      T63898849150-59-0In house
      Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)- is a dual PPARα/γ agonist with EC50 of 0.358μM and 1.21μM. Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αR)- is the R-isomer of Aleglitazar.
      • $195
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      DGAT-1 inhibitor 2
      T11016942999-61-3In house
      DGAT-1 inhibitor 2 is an effective DGAT-1 inhibitor and anti-obesity drug. DGAT-1 (acyl-CoA: diacylglycerol acyltransferase 1) is one of two known DGAT enzymes that catalyze the final step of triglyceride synthesis. Transgenic mice and pharmacological studies indicate that inhibiting DGAT1 is a promising strategy for treating obesity and type 2 diabetes.
      • $35
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      IDH2R140Q-IN-2
      T797452749568-16-7In house
      IDH2R140Q-IN-2 is an orally active and potent IDH2R140Q inhibitor with an IC50 of 29 nM.IDH2R140Q-IN-2 possesses potential antitumour activity, reducing D2HG production in TF-1 cell lines carrying the IDH2R140Q mutation (IC50 of 10 nM) and inhibiting tumour tissue D2HG levels.IDH2R140Q-IN-2 is suitable for the study of acute myeloid leukaemia (AML).
      • $397 TargetMol
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      SARS-CoV-2 3CLpro-IN-16
      T79659352659-40-6In house
      SARS-CoV-2 3CLpro-IN-16 is a covalent inhibitor of SARS-CoV-2 3CLpro activity, exerting its effect by forming a covalent bond with Cys145.
      • $195 TargetMol
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      SARS-CoV-2 Mpro-IN-2
      T630982768834-39-3In house
      SARS-CoV-2 Mpro-IN-2 is a selective SARS-CoV-2M pro inhibitor with an IC50 value of 0.40 μM.SARS-CoV-2 Mpro-IN-2 has good antiviral activity and can be used to study COVID-19.
      • $397 TargetMol
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      3-(2,6-dichlorobenzyl)-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide
      T60222 In house
      3-(2,6-dichlorobenzyl)-1-hexadecyl-2-methyl-1H-imidazol-3-ium iodide is a potent inhibitor of fructose-1,6-bisphosphate aldolase.
      • $117
      Backorder
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      Ceranib-2
      T107611402830-75-4In house
      Ceranib-2 (3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one) is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decreases levels of sphingosine and S1P, induces cell apoptosis and exhibits anticancer activity.
      • $29
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      YK-2-69
      T695642619846-89-6In house
      YK-2-69 is a highly selective DYRK2 inhibitor with anti-prostate cancer effects.
      • $293 TargetMol
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      1-(6-Methoxy-2-naphthyl)ethanol
      T061277301-42-9
      1-(6-Methoxy-2-naphthyl)ethanol is used as pharmaceutical intermediates.
      • $29
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      2-Amino-5-ureidopentanoic acid
      T2931627-77-0
      2-Amino-5-ureidopentanoic acid (Citrulline) exists in the liver, is not a protein component, is an important intermediate in the human urea cycle, can be combined with ornithine, arginine to treat hyperammonemia.
      • $40
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      2-tert-Butyl-1,4-benzoquinone
      TN67503602-55-9
      2-tert-Butyl-1,4-benzoquinone (TBQ), an electrophilic metabolite of butylated hydroxyanisole (BHA), activates Nrf2 and S-arylates its negative regulator Keap1 in RAW264.7 cells.
      • $29
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      4,4'-Disulfanediylbis(2-aminobutanoic acid)
      T5276462-10-2
      4,4'-Disulfanediylbis(2-aminobutanoic acid) (DL-Homocystine) is the double-bonded form of homocysteine that occurs transiently before being converted to harmless cystathionine via a vitamin B6-dependent enzyme. Homocystine and homocysteine-cysteine mixed disulfide account for over 98% of total homocysteine in plasma from healthy individuals.
      • $29
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      2-Amino-4'-fluorobenzophenone
      T79373800-06-4
      2-Amino-4'-fluorobenzophenone is a derivative of benzophenone. It is used in the synthesis of p-fluorobenzoyl chloride and has also been used as a fluorescent probe for biochemical studies such as DNA and RNA detection.
      • $30
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      2-Acetyl-6-methoxynaphthalene
      T06373900-45-6
      2-Acetyl-6-methoxynaphthalene, the key intermediate of naphthalene tome and naproxen, is used in synthetic non-steroidal anti-inflammatory analgesic medicine and.
      • $34
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      2-Acetonaphthone
      T2058793-08-3
      2-Acetonaphthone (beta-Naphthyl methyl ketone) is a fragrance, anticonvulsant, and antimicrobial agent. It has an onion type flavor and a sulfurous type odor.
      • $58
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      2-Pyridylethylamine dihydrochloride
      T225013343-39-3
      2-Pyridylethylamine dihydrochloride is a Histamine H1 receptor agonist.
      • $38
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      2-Ethylbutyric Acid
      T802788-09-5
      2-Ethylbutyric acid is an internal standard that can be used in calibration methods for VFA analytical standards for feces.
      • $35
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      2-O-α-D-Glucopyranosyl-L-ascorbic Acid
      T8172129499-78-1
      2-O-α-D-Glucopyranosyl-L-ascorbic Acid (ASCORBYL GLUCOSIDE), a glucoside derivative of ascorbic acid, exhibits anti-cancer properties upon enzymatic conversion to ascorbic acid.
      • $40
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      Sodium 2-hydroxybutanoate
      T47385094-24-6
      Sodium 2-hydroxybutanoate (alpha-hydroxybutyrate) is formed as a by-product of the formation of alpha-ketobutyrate via a reaction catalyzed by lactate dehydrogenase (LDH) or alpha-hydroxybutyrate dehydrogenase (alphaHBDH).
      • $29
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