Search Result

Search Results for " cotransporter "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T2010	S0859		Others
	S0859 is an N-cyanosulphonamide that blocks the sodium/bicarbonate cotransporter (NBC, also known as SLC4A7), which regulates intracellular pH.		Others
T38843	Enavogliflozin	DWP-16001	SGLT
	Enavogliflozin (DWP-16001) is an orally available small molecule and sodium glucose transporter 2 inhibitor.		SGLT
TQ0011	PF-06869206		Sodium Channel
	PF-06869206 is an oral selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1, IC50: 380 nM).		Sodium Channel
T17243	VU0463271	N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide	Potassium Channel
	VU0463271 (N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide) is a potent and selective antagonist of the neuronal-specific potassium-chloride cotransporter 2 (KCC2), with an IC50 of 61 nM ...		Potassium Channel
T5444	CLP290	CLP-290	Potassium Channel
	CLP290 is an activator of the neuron-specific K+-Cl cotransporter KCC2 and displays potential for the treatment of a wide range of neurological and psychiatric indications.		Potassium Channel
TQ0139	VU 0240551	N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide,VU0240551-2-D4	Potassium Channel , Calcium Channel , HER
	VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG.		Potassium Channel , Calcium Channel , HER
T4999	Ertugliflozin	MK-8835,PF-04971729	SGLT
	PF-04971729 (Ertugliflozin (PF-04971729)) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2).		SGLT
T14984	CLP257		Potassium Channel
	CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it al...		Potassium Channel
T4564	Ethacrynic acid	Edecrin,Etacrynic Acid,Hydromedin	Others , Calcium Channel , NF-κB , GST
	Ethacrynic acid (Edecrin) is a nonsulfonamide loop diuretic that inhibits the activity of the Na+/K+/2Cl- cotransporter NKCC2 in the thick ascending limb of the loop of Henle. It also inhibits glutathione S-transferase a...		Others , Calcium Channel , NF-κB , GST
T35336	Furosemide sodium	Frusemide Sodium,Lasix	Na-K-Cl cotransporter
	Furosemide sodium (Frusemide Sodium) is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide sodium is also a GABAA receptors antagonist and displays 100-fold selectivity ...		Na-K-Cl cotransporter
T16818	S-8921		Others
	S-8921 is an inhibitor of ileal Na+/bile acid cotransporter.		Others
T11528	H100		Others
	H100 is a Cl- transport inhibitor, no effect against KCl cotransporter. It has partial effects against both the NaK2Cl cotransporter and the Band 3 anion exchanger.		Others
T17221	Velagliflozin		SGLT
	Velagliflozin is an orally available inhibitor of sodium-glucose cotransporter 2.		SGLT
T30534	BMS-639432
	BMS-639432 is a potent sodium-glucose cotransporter type II (SGLT2) inhibitor.
T15752	Licogliflozin	LIK066	SGLT
	Licogliflozin (LIK066) is an inhibitor of sodium-glucose cotransporter (SGLT1 and SGLT2).		SGLT
T21399	Luseogliflozin	TS71,TS-071,TS 71,TS071,TS-71,TS 071
	Luseogliflozin, a potent and competitive inhibitor of sodium-dependent glucose cotransporter 2 (SGLT2), competitively inhibits human SGLT2-mediated glucose uptake with a Ki value of 1.10 nM.
T28971	Tianagliflozin
	Tianagliflozin, a sodium/glucose cotransporter 2 (SGLT-2) inhibitor, is used potentially for the treatment of type 2 diabetes.
T15797	LX2761		Others
	LX2761 is a chemically stable and effective inhibitor against sodium-dependent glucose cotransporter 1 (SGLT1) and SGLT2 (IC50s: 2.2 nM and 2.7nM for hSGLT1 and hSGLT2). However, it shows specific SGLT1 inhibition in the...		Others
T12892	SGL5213		SGLT
	SGL5213 is an oral active and low-absorbable inhibitor of sodium-dependent glucose cotransporter 1 (SGLT1)(hSGLT1 and hSGLT2 with IC50 values of 29 nM and 20 nM , respectively),and has potential to treat type 2 diabetes.		SGLT
T13179	Tofogliflozin	CSG452	Others
	Tofogliflozin is a highly specific inhibitor of sodium/glucose cotransporter 2 (SGLT2) (Kis: 2.9, 14.9, and 6.4 nM for human, rat, and mouse SGLT2. IC50s: 2.9/14.9/6.4 nM (human/rat/mouse SGLT2)).		Others
T68236	TP0438836
	TP0438836 is a potent, low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor for the treatment of type 2 diabetes. TP0438836 showed IC50 values 28nM and 7 nM for hSGLT1 and hSGLT2 resepctively.
T61713	Bumetanide sodium
	Bumetanide sodium is a potent loop diuretic that acts as a blocker for the sodium-potassium-chloride cotransporter (NKCC). It selectively inhibits NKCC1 and NKCC2, with IC50 values of 0.68 μM and 4.0 μM for hNKCC1A and h...
T35728	Hydrochlorothiazide Impurity C
	Hydrochlorothiazide impurity C is a potential impurity found in commercial hydrochlorothiazide preparations. [1] Hydrochlorothiazide is a thiazide diuretic that inhibits the apical membrane sodium chloride cotransporter ...
T68922	YM543 free base
	YM543 free base, a potent and orally active sodium-glucose cotransporter (SGLT) 2 inhibitor, effectively reduces blood glucose levels and is suitable for diabetes research.
T35619	Dapagliflozin-3-O-β-D-Glucuronide
	Dapagliflozin-3-O-β-D-glucuronide is a metabolite of dapagliflozin . Dapagliflozin is a first generation selective sodium glucose cotransporter (SGLT) 2 inhibitor that blocks glucose transport.[1] Dapagliflozin is metab...
T70390	YM-543 choline
	YM-543, also known as ASP-543, is a selective SGLT2 inhibitor. Sodium-glucose cotransporter 2 (SGLT2) is a specifically expressed transporter in the kidney that plays an important role in renal glucose reabsorption, and ...
T72143	Velagliflozin proline hydrate
	Velagliflozin proline hydrate, the clinical form of Velagliflozin, is an oral sodium-glucose cotransporter 2 (SGLT2) inhibitor exhibiting antidiabetic activity. By decreasing renal glucose reabsorption and promoting glyc...
T35876	Chlorthalidone Impurity G
	Chlorthalidone impurity G is a potential impurity found in commercial preparations of chlorthalidone that has moderate antihypertensive effects. Chlorthalidone is a thiazide-like diuretic that inhibits the Na+/Cl- cotran...

Compounds

Target: Sodium Channel

VU0463271

T17243

Synonym: N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide

Target: Potassium Channel

CLP290

T5444

Synonym: CLP-290

Target: Potassium Channel

VU 0240551

TQ0139

Synonym: N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide,VU0240551-2-D4

Target: Potassium Channel, Calcium Channel, HER

Ertugliflozin

T4999

Synonym: MK-8835,PF-04971729

Target: Potassium Channel

Ethacrynic acid

T4564

Synonym: Edecrin,Etacrynic Acid,Hydromedin

Target: Others, Calcium Channel, NF-κB, GST

Furosemide sodium

T35336

Synonym: Frusemide Sodium,Lasix

Target: Na-K-Cl cotransporter

Synonym: TS71,TS-071,TS 71,TS071,TS-71,TS 071

Hydrochlorothiazide Impurity C

Dapagliflozin-3-O-β-D-Glucuronide

Velagliflozin proline hydrate

T72143

Synonym:

Target:

Chlorthalidone Impurity G

T35876

Synonym:

Target:

Cat No.	Product Name	Synonyms	Targets
TN1842	Kushenol I		GABA Receptor , Antifection
	Kushenol I is a GABAA receptor modulator, it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).Kushenol I is shown to be active against the plant pathogenic fungus Cladosporium cucumeri...		GABA Receptor , Antifection
TN1847	Kushenol X		Others
	Kushenol X exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).		Others
TN1841	Kushenol A	Leachianone E	cAMP
	Kushenol A is a kind of Adenosine 3', 5'-cyclic monophosphate(cAMP)phosphodiesterase inhibitiors, it shows selective alpha-glucosidase inhibitory activity. Kushenol A and kushenol C exhibit inhibitory activity against So...		cAMP
TN4399	Kushenol C		SGLT , NF-κB , ROS , BACE , Antifection
	Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2). Kushenol C shows antimicrobial activity against Staphyloco...		SGLT , NF-κB , ROS , BACE , Antifection
TN2553	1-Methyl-2-undecyl-4(1H)-quinolone	1-Methyl-2-undecylquinolin-4(1H)-one	MAO
	1-Methyl-2-undecyl-4(1H)-quinolone, and dihydroevocarpine should also be served as the chemical markers together with evodiamine for the quality control of Evodia rutaecarpa (Juss.) Benth. 1-Methyl-2-undecyl-4(1H)-quinol...		MAO

Natural Products

Kushenol I

TN1842

Synonym:

Target: GABA Receptor, Antifection

Synonym: Leachianone E

Target: SGLT, NF-κB, ROS, BACE, Antifection

1-Methyl-2-undecyl-4(1H)-quinolone

TN2553

Synonym: 1-Methyl-2-undecylquinolin-4(1H)-one

Target: MAO

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-02124	SLC23A2 Protein, Human, Recombinant (His)	Human	in vitro E. coli expression system
	Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.
TMPH-02119	SLC5A2 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.; Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affini...
TMPJ-00935	PDIA3 Protein, Human, Recombinant (His)	Human	Human Cells
	PDIA3 protein is also known as Protein disulfide-isomerase A3. It is a protein that in humans is encoded by the PDIA3 gene.PDIA3 is an enzyme that belongs to the endoplasmic reticulum and interacts with lectin chaperones...

SLC23A2 Protein, Human, Recombinant (His)

TMPH-02124

Species: Human

Expression System: in vitro E. coli expression system

SLC5A2 Protein, Human, Recombinant (His & Myc)

TMPH-02119

Species: Human

Expression System: E. coli

PDIA3 Protein, Human, Recombinant (His)

TMPJ-00935

Species: Human

Expression System: Human Cells