cni

Secnidazole (PM-185184) is a second-generation 5-nitroimidazole antimicrobial that is structurally related to other 5-nitroimidazoles including [DB00916] and [DB00911], but displays improved oral absorption and longer terminal elimination half-life than antimicrobial agents in this class [A27210]. Secnidazole is selective against many anaerobic Gram-positive and Gram-negative bacteria and protozoa.

Cnidioside B is a natural product that can be used as a reference standard. The CAS number of Cnidioside B is 141896-54-0.

Cnidioside A is a natural product that can be used as a reference standard. The CAS number of Cnidioside A is 141896-53-9.

Secnidazole hemihydrate (RP-14539), an orally ingestible azole derivative antibiotic and imidazole-based Serratia marcescens virulence suppressor, analogously inhibits acylhomoserine lactones, mitigating Pseudomonas aeruginosa pathogenicity through quorum sensing (QS) disruption. This compound exhibits broad-spectrum antimicrobial efficacy against numerous anaerobic Gram-negative and Gram-positive bacteria in vitro. Its therapeutic application spans the study and treatment of ailments including amoebiasis, giardiasis, and bacterial vaginitis [1] [2] [3].

µ-Conotoxin-CnIIIC acetate is a potent NaV1.4 sodium channel antagonist, a conotoxin peptide consisting of 22 amino acids, used for muscle relaxation and pain relief.

μ-Conotoxin-CnIIIC, a 22-residue conopeptide derived from Conus consors, acts as a potent and persistent NaV1.4 channel blocker, exhibiting analgesic, anaesthetic, and myorelaxant properties [1] [2].

Cnidilin (Knidilin) is found in association with Angelica dahurica roots, has high BBB permeability and has pharmacokinetic potential in the treatment of CNS disorders.

Cnicin is a natural product

Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 microM). Cnidicin exhibits a significant inhibition on the proliferation of cultured human tumor

Neocnidilide is an alkyl phthalate derived from Rhizoma Ligustici Chuanxiong with the ability to inhibit the growth of mycotoxin-producing fungi and to kill insects.The LC50 value of Neocnidilide against D. melanogaster larvae was 9.9 μmol mL.It enhances the skin penetration of benzoic acid.The LC50 value of Neocnidilide against D. melanogaster larvae was 9.9 μmol mL.It enhances the skin penetration of benzoic acid.

Cnidimol A is a natural product from Cnidium monnieri.

Cnidioside B exerts little immunomodulatory effect in RAW 264.7 cells.

Cnidimol B is a natural product.

Withacnistin, a solanidine extracted from Lochronia cocrineuni, is utilized in cancer research.

CNI103 is a potent and metabolically stable inhibitor of the cell-permeable peptide, calcineurin. It selectively inhibits the interaction between calcineurin and NFATc3 (KD=16 nM), thereby preventing the activation of NFATc3 both in vitro and in vivo. CNI103 is applicable for research in acute respiratory distress syndrome (ARDS) and other inflammatory diseases.

t-Boc-aminocaproicnitrilotriacetic acid is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Semapimod is an inhibitor of proinflammatory cytokine production, capable of suppressing TNF-α, IL-1β, and IL-6. It hinders TLR4 signaling with an IC50 of approximately 0.3 μM, impedes p38 MAPK, and reduces nitric oxide production in macrophages. This compound shows promise for treating various inflammatory and autoimmune disorders [1] [2] [3].