cd28 antigen

Expression system: HEK293 Cells
Length: 19-152, Extracellular Domain
Activity: BLI

Expression system: HEK293 Cells
Length: 19-152, Extracellular Domain
Activity: BLI、ELISA

Expression system: HEK293 Cells
Length: 19-152, Extracellular Domain
Activity: ELISA、SPR

Expression system: HEK293 Cells
Length: 19-152, Extracellular Domain
Activity: ELISA

Expression system: HEK293 Cells
Length: 18-153, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 18-153, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 20-149, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 37-161, Extracellular Domain
Activity: Not Tested

Cynomologous Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily.It is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells.CD80 plays key, yet distinct roles in the activation of T cells. B7-1 CD80 and B7-2 CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.

Expression system: HEK293 Cells
Length: 33-241, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 20-220, Partial
Activity: SPR

B- and T-lymphocyte attenuator (BTLA; CD272) is a 35 kDa type I transmembrane glycoprotein in the CD28 family of T cell costimulatory molecules. BTLA is a inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6 SHP-1 and PTPN11 SHP-2. BTLA may interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. BTLA Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 15.04 kDa and the accession number is A0A2K5W7M7.

B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the activation and regulation of T cell immunity. B7-1 and B7-2 do not form hetero-oligomers, underscoring the biological relevance of dimeric and monomeric state of B7-1 and B7-2, respectively. B7-2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 26.4 kDa and the accession number is G7NXR4.

Expression system: HEK293 Cells
Length: 26-247, Partial
Activity: ELISA

Expression system: HEK293 Cells
Length: 26-247, Partial
Activity: ELISA

Expression system: HEK293 Cells
Length: 26-247, Partial
Activity: ELISA

Expression system: HEK293 Cells
Length: 31-150, Partial
Activity: ELISA、SPR

PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine production by CD4 T cells. At low antigen concentrations, PD-L2-PD-1 interactions inhibit strong B7-CD28 signals. PD-L2 Protein, Cynomolgus, Recombinant (aa 20-220, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 23.73 kDa and the accession number is A0A2K5U5Z4.