atf4

Expression system: E. coli
Length: 1-347, Full Length
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 1250-1599, Partial
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 1-358, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1250-1599, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 26-96, Partial
Activity: Not Tested

Expression system: E. coli
Length: 2-118, Full Length of Mature Protein
Activity: Not Tested

Death-associated protein kinase 3, also known as DAP kinase 3, ZIP-kinase, DAPK3 and ZIPK, is a nucleus and cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser Thr protein kinase family and DAP kinase subfamily. DAPK3 ZIPK contains oneprotein kinase domain. It is a serine threonine kinase which acts as a positive regulator of apoptosis. It phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. DAPK3 ZIPK is a homodimer or forms heterodimers with ATF4. Both interactions require an intact leucine zipper domain and oligomerization is required for full enzymatic activity. It also binds to DAXX and PAWR, possibly in a ternary complex which plays a role in caspase activation. DAPK3 ZIPK regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. It is involved in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection.