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at 533

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AT-533
T67836908112-37-8
AT-533 is a potent inhibitor of Hsp90 and HSV. AT-533 blocks the HIF-1α VEGF VEGFR-2 signaling pathway, leading to suppress tumor growth and angiogenesis. AT-533 also inhibits the activation of the downstream pathways, including Erk1 2, FAK, Akt mTOR p70S6K,. AT-533 inhibits the cell migration, invasion, and the tube formation of human umbilical vein endothelial cells (HUVECs).
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