antimutagenic

Bilirubin (Principal bile pigment) is a type of bile pigment, which is a metabolite of hemoglobin in the blood. Bilirubin has antimutagenic and antioxidant effects. Bilirubin is an important basis for clinical determination of jaundice, and is also an important indicator of liver function.

Lupeol (Monogynol B) is a novel androgen receptor inhibitor with anti-inflammatory and antioxidant activity.

Sakuranetin, a flavanone phytoalexin from ultraviolet-irradiated rice leaves, it has antifungal, antimutagenic, anti-inflammatory and antioxidant effects

1. Lutein (Xantofyl) has antitumour action. 2. Lutein has antimutagenic action. 3. Lutein has a wide range of antimicrobial action. 4. Lutein is potentially useful for treating macular degeneration.

(L)-Canavanine is antimutagenic activity.

Bilirubin conjugate is a stable, water-soluble ditaurate derivative of bilirubin meant to mimic endogenous bilirubin glucuronide derivatives. In vivo, bilirubin circulates in the plasma and is taken up by hepatocytes and conjugated to one or two glucuronic acids in a reaction catalyzed by UDP glucuronidase to form bilirubin mono or diglucuronide. This water-soluble form is then excreted from the liver in bile in the feces or is converted to urobilinogen and excreted in the urine. In addition to aiding in the disposal of heme, bilirubin and its conjugated derivatives have been shown to exhibit anti-oxidant and antimutagenic effects and to play a role in gut barrier function.

1, 2, 3, 4, 6-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) and gallic acid from Pistacia lentiscus have antimutagenic and antioxidant activities. 2. 1, 2, 3, 4, 6-Penta-O-galloyl-beta-D-glucose (PGG) possesses potent anti-proliferative and anti-invasive effects, it also has inhibition of inducible nitric oxide synthase and cyclooxygenase-2 activity. 3. PGG may serve as a model for the development of new types of anti-diabetic and anti-metabolic syndrome therapeutics. 4. 1, 2, 3, 4, 6-Penta- O -galloyl-β- d -glucose has vasodilatory and anti-inflammatory effects, it dilates vascular smooth muscle and suppresses the vascular inflammatory process via endothelium-dependent nitric oxide (NO)/cGMP signaling. 5. 1, 2, 3, 4, 6-Penta-O-galloyl-beta-D-glucose can decrease the level of extracellular hepatitis B virus (HBV) (IC5, 1. microg/ml) in a dose-dependent manner, it also can reduce the HBsAg level by 25% at a concentration of 4 microg/ml; the gallate structure of PGG may play a critical role in the inhibition of anti-HBV activity, suggests that PGG could be a candidate for developing an anti-HBV agent. 6. 1, 2, 3, 4, 6-Penta-O-galloyl-β-D-glucose has anti-parasitic activity, displays an EC5 value of 67 μM, at least 6.6-fold more effective than the standard drug benznidazole against trypomastigote forms of T. cruzi.

AV-153 is a 1,4-dihydropyridine derivative with antimutagenic properties. It intercalates into DNA at single strand breaks, resulting in reduced DNA damage and stimulation of DNA repair in human cells in vitro. AV-153 also interacts with thymine and cytosine and influences poly(ADP)ribosylation. Moreover, AV-153 exhibits anti-cancer activity.

9,10-Dichlorostearic acid is a chlorinated stearic acid with antimutagenic properties. In vitro studies indicate that it induces membrane damage in mammalian tumor cells, resulting in the leakage of adenosine triphosphate (ATP).

AV-153 free base is a 1,4-dihydropyridine (1,4-DHP) derivative with antimutagenic and anti-cancer activity. It interacts with cytosine and thymine, influences poly(ADP)ribosylation, intercalates to DNA at single-strand breaks, reduces DNA damage, and stimulates DNA repair in human cells in vitro [1] [2] [3].

1. Oxypeucedanin hydrate (Prangolarin Hydrate) has antioxidant activity. 2. Oxypeucedanin hydrate is an antimutagenic agent. 3. Oxypeucedanin hydrate exhibits carbohydrate metabolizing enzymes inhibitory effect.

Spilanthol, an orally active compound with analgesic, neuroprotective, antioxidant, antimutagenic, anti-cancer, anti-inflammatory, antimicrobial, and insecticidal properties, facilitates the induction of cAMP, thereby inhibiting the negative regulation of the urinary concentration mechanism. It is also utilized in diuretic research [1] [4] [5].

Pentagalloylglucose (Standard) is a reference standard for research and analysis in studies involving Pentagalloylglucose. 1, 2, 3, 4, 6-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) and gallic acid from Pistacia lentiscus have antimutagenic and antioxidant activities. 2. 1, 2, 3, 4, 6-Penta-O-galloyl-beta-D-glucose (PGG) possesses potent anti-proliferative and anti-invasive effects, it also has inhibition of inducible nitric oxide synthase and cyclooxygenase-2 activity. 3. PGG may serve as a model for the development of new types of anti-diabetic and anti-metabolic syndrome therapeutics. 4. 1, 2, 3, 4, 6-Penta- O -galloyl-β- d -glucose has vasodilatory and anti-inflammatory effects, it dilates vascular smooth muscle and suppresses the vascular inflammatory process via endothelium-dependent nitric oxide (NO)/cGMP signaling. 5. 1, 2, 3, 4, 6-Penta-O-galloyl-beta-D-glucose can decrease the level of extracellular hepatitis B virus (HBV) (IC5, 1. microg/ml) in a dose-dependent manner, it also can reduce the HBsAg level by 25% at a concentration of 4 microg/ml; the gallate structure of PGG may play a critical role in the inhibition of anti-HBV activity, suggests that PGG could be a candidate for developing an anti-HBV agent. 6. 1, 2, 3, 4, 6-Penta-O-galloyl-β-D-glucose has anti-parasitic activity, displays an EC5 value of 67 μM, at least 6.6-fold more effective than the standard drug benznidazole against trypomastigote forms of T. cruzi.

Lutein (Standard) is the standard substance of Lutein, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. 1. Lutein (Xantofyl) has antitumour action. 2. Lutein has antimutagenic action. 3. Lutein has a wide range of antimicrobial action. 4. Lutein is potentially useful for treating macular degeneration.

Oxypeucedanin hydrate (Standard) is a reference standard for research and analysis in studies involving Oxypeucedanin hydrate. 1. Oxypeucedanin hydrate (Prangolarin Hydrate) has antioxidant activity. 2. Oxypeucedanin hydrate is an antimutagenic agent. 3. Oxypeucedanin hydrate exhibits carbohydrate metabolizing enzymes inhibitory effect.

Sakuranetin (Standard) is a reference standard for research and analysis in studies involving Sakuranetin. Sakuranetin, a flavanone phytoalexin from ultraviolet-irradiated rice leaves, it has antifungal, antimutagenic, anti-inflammatory and antioxidant effects

(-)-Byakangelicin (Compound 9) is a furanocoumarin compound found in the peel of lemons (Citrus limon). It exhibits antimutagenic activity against Trp-P-1 and PhIP, making it useful for cancer research.

Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3/6-p38 signaling pathway.Gossypetin exhibits antimutagenic, antiatherosclerotic, antioxidant, as well as cytoprotective and antimicrobial effects.It inhibits bone resorption by downregulating lysosomal caspase K activity and inducing autophagy-associated proteins in actin ring osteoclasts. Gossypetin has anti-mutagenic, anti-atherosclerotic, anti-oxidant, cytoprotective and antibacterial effects, and it inhibits bone resorption by down-regulating lysosomal caspase K activity and by inducing autophagy-associated protein in actin ring osteoblasts.

Persicogenin has anticancer, antimutagenic, and antileishmanial activities, it can inhibit the proliferation of mouse tsFT210 cancer cells, it mainly inhibits cell cycle at the G2/M phase in a dose-dependent manner.

Pinocembrin chalcone is an inhibitor of tyrosinase with antimutagenic effects. Pinocembrin chalcone can be used in studies about the prevention of gastric ulcers.

Soyasaponin IV has hepatoprotective activity.It also has antimutagenic activity in mammalian cells.

Tectoruside is a phenolic glycoside derived from Iris and Leopard lily with antimutagenic and antioxidant activity that attenuates palmitate-induced endothelial insulin resistance by targeting ROS-associated inflammation and the IRS-1 pathway Tectoruside can be used in cancer research.

Biliverdin dihydrochloride is a tetrapyrrolic pigment resulting from the degradation of heme. Heme is broken down by heme oxygenase into biliverdin, carbon monoxide, and iron. Subsequently, biliverdin is rapidly converted to bilirubin by biliverdin reductase. Biliverdin dihydrochloride exhibits antimutagenic, antioxidant, anti-inflammatory, and immunosuppressive properties.