adrenal gland

Cosyntropin (acetate) stimulates the release of corticosteroids such as cortisol from the adrenal gland.

Tetracosactide (Tetracosactrin) (INN) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone.

ACTH 1-14 acetate(25696-21-3 free base) (Adrenocorticotropic Hormone Fragment 1-14 acetate) is a fragment of adrenocorticotrophin, which regulates cortisol and androgen production.Adrenocorticotropic hormone (ACTH), also known as corticotropin, is produced and secreted by the anterior pituitary gland. ACTH is an important component of the hypothalamic-pituitary-adrenal axis as a response to biological stress.

Deoxycorticosterone (Desoxycortone) is a steroid metabolite produced by the adrenal gland. Deoxycorticosterone is an aldosterone precursor and possesses mineralocorticoid activity.

Cortodoxone (11-Desoxycortisol) is a glucocorticoid steroid hormone that is an intermediate in the biosynthesis of cortisol in the adrenal gland.

ZD 7155 hydrochloride is a potent and selective competitive antagonist for the angiotensin II type 1 (AT1) receptor. It displaces [125I]-angiotensin II binding in guinea pig adrenal gland membranes with an IC50 value of 3.8 nM.

Forasartan is a non - peptide angiotensin II receptor antagonist with antihypertensive activity. Forasartan and angiotensin II compete to bind AT1 receptor subtypes in vascular smooth muscle, thereby blocking angiotensin II-mediated vasoconstriction, lead

PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin , glucagon , glucagon-like peptide-1 , GLP-2 , and pituitary adenylate cyclase-activating polypeptide . It is expressed in normal human pancreas and adrenal gland tissue and in some tumors that produce vasoactive intestinal peptide (VIP). PRP (1-29) is secreted by CHO-K1 cells that express human recombinant preproPACAP.

Cholesteryl homo-γ-linolenate, a cholesterol ester, accumulates in the adrenal gland of rabbits on a linolenic acid-rich diet. In HIV-infected humans, levels of cholesteryl homo-γ-linolenate decrease and positively correlate with cognitive decline.

Syringaresinol diglucoside (Syringaresinol-di-O-glucoside) protects the animals from the stress-induced decreases in sex behaviours and in rectal temperature, the stress-induced failure of retrieval of memory, and the stress-induced enlargement of adrenal gland.

1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and angiogenic factors. 2. Acetylshikonin inhibits the generation of NADPH oxidase complex in the activation of respiratory burst of PMNs, but does not directly inhibit the activity of NADPH oxidase already generated. 3. Certain shikonin derivatives(such as Acetylshikonin) act as modulators of the Nur77-mediated apoptotic pathway and identify a new shikonin-based lead that targets Nur77 for apoptosis induction. 4. Acetylshikonin, shikonin, and alkannin have accelerative effect on the proliferation of granulation tissue in rats. 5. Acetylshikonin has inhibitory effect on the edematous response is due neither to the release of steroid hormones from the adrenal gland nor to the glucocorticoid activity, but probably partly to the suppression of mast cell degranulation and partly to protection of the vasculature from mediator challenge. 6. Acetylshikonin induces apoptosis of hepatitis B virus X protein-expressing human hepatocellular carcinoma cells via endoplasmic reticulum stress.

Adrenocorticotropic hormone (ACTH) is a polypeptide tropic hormone secreted by the anterior pituitary. Adrenocorticotropic hormone stimulates the adrenal cortex to release cortisol via the hypothalamic-pituitary-adrenal (HPA) axis and regulates the production of both cortisol and androgens. This hormone also promotes the progression of sperm development. In gout models, adrenocorticotropic hormone alleviates acute inflammatory responses by inhibiting macrophage polarization toward the M1 phenotype, reducing the production of reactive oxygen species (ROS) and pro-inflammatory cytokines, and protecting mitochondrial function.

Nonapeptide-1 (Melanostatine-5) acetate salt is a peptide hormone that functions as a selective and competitive antagonist of the melanocortin 1 receptor (MC1R) with a binding affinity (K i) of 40 nM. It effectively inhibits α-MSH-induced increases in intracellular cyclic AMP (cAMP) and melanosome dispersion in melanocytes, with inhibitory concentrations (IC 50) of 2.5 nM and 11 nM, respectively. By inhibiting melanin synthesis, Nonapeptide-1 acetate salt is used in research related to skin pigmentation, adrenal gland steroid production regulation, and skin cancer [1] [2] [3].

PACAP (6-27) (human, ovine, rat) is an antagonist for the PACAP receptor, inhibiting the catecholamine response of the canine adrenal gland to vasoactive intestinal peptide (VIP), making it a valuable compound for research into cardiovascular and neurological disorders [1].

Hydrin 1′, isolated from the neurohypophysis of Xenopus, exhibits significant steroid-releasing activity in the species' adrenal gland in vitro [1].

18-Hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid produced by the zona fasciculata of the adrenal gland, with its biosynthesis regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. This regulation heightens 18-OH-DOC production in isolated human adrenal glomerulosa cells and allows for its formation from 11-deoxy corticosterone (DOC) in human SK-MEL188 melanoma cells. As an intermediate in progesterone metabolism, 18-OH-DOC can be converted to aldosterone in rat adrenal glands' capsular portion. Its continuous infusion (200 μg/rat per day) has been shown to raise systolic blood pressure in uninephrectomized saline-drinking rats, and elevated plasma levels of 18-OH-DOC have been observed in the adb/db mouse model of type 2 diabetes.

11-Deoxycorticosterone-D8 is a deuterated compound of 11-Deoxycorticosterone. 11-Deoxycorticosterone (T20302) has a CAS number of 64-85-7. Deoxycorticosterone is a steroid metabolite produced by the adrenal gland. Deoxycorticosterone is an aldosterone precursor and possesses mineralocorticoid activity.

11-Deoxycortisol-2,2,4,6,6-D5 is a deuterated compound of 11-Deoxycortisol. 11-Deoxycortisol (T2748) has a CAS number of 152-58-9. Cortodoxone is a glucocorticoid steroid hormone that is an intermediate in the biosynthesis of cortisol in the adrenal gland.

Dehydroepiandrosterone-2,2,3,4,4,6-D6 is a deuterated compound of Dehydroepiandrosterone. Dehydroepiandrosterone (T0856L) has a CAS number of 53-43-0. Dehydroepiandrosterone (T0856L) (DHEA) is an endogenous steroid hormone that is secreted primarily by the adrenal gland and is the most abundant sex steroid. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may result in both direct and indirect physiologic effects. Direct effects include GABA-a receptor complex and NMDA receptor modulation and enhanced pancreatic beta cell insulin secretion and anti-glucocorticoid activities.

Tetrahydrocorticosterone-d3-1 is the deuterium-labeled form of Tetrahydrocorticosterone. Tetrahydrocorticosterone is a glucocorticoid with notable anti-inflammatory properties. Its active form, 5α-Tetrahydrocorticosterone, works by binding to glucocorticoid (GC) receptors and inhibiting inflammatory processes. Naturally synthesized by the adrenal gland, Tetrahydrocorticosterone plays a crucial role in regulating the metabolism of carbohydrates, proteins, and fats.

Deoxycorticosterone (Standard) is a reference standard for research and analysis in studies involving Deoxycorticosterone. Deoxycorticosterone (Desoxycortone) is a steroid metabolite produced by the adrenal gland. Deoxycorticosterone is an aldosterone precursor and possesses mineralocorticoid activity.

11-Deoxycortisol-2,2,4,6,6-D5 (Standard) is a reference standard of 11-Deoxycortisol-2,2,4,6,6-D5 intended for quantitative analysis, quality control, and related biochemical research applications. 11-Deoxycortisol-2,2,4,6,6-d5 is a deuterated compound of 11-Deoxycortisol. 11-Deoxycortisol has a CAS number of 152-58-9. Cortodoxone is a glucocorticoid steroid hormone that is an intermediate in the biosynthesis of cortisol in the adrenal gland.

Dehydroepiandrosterone-2,2,3,4,4,6-D6 (Standard) is a reference standard of Dehydroepiandrosterone-2,2,3,4,4,6-D6 intended for quantitative analysis, quality control, and related biochemical research applications. Dehydroepiandrosterone-2,2,3,4,4,6-d6 is a deuterated compound of Dehydroepiandrosterone. Dehydroepiandrosterone has a CAS number of 53-43-0. Dehydroepiandrosterone (DHEA) is an endogenous steroid hormone that is secreted primarily by the adrenal gland and is the most abundant sex steroid. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may result in both direct and indirect physiologic effects. Direct effects include GABA-a receptor complex and NMDA receptor modulation and enhanced pancreatic beta cell insulin secretion and anti-glucocorticoid activities.

11-Deoxycorticosterone-D8 (Standard) is a reference standard of 11-Deoxycorticosterone-D8 intended for quantitative analysis, quality control, and related biochemical research applications. 11-Deoxycorticosterone-d8 is a deuterated compound of 11-Deoxycorticosterone. 11-Deoxycorticosterone has a CAS number of 64-85-7. Deoxycorticosterone is a steroid metabolite produced by the adrenal gland. Deoxycorticosterone is an aldosterone precursor and possesses mineralocorticoid activity.