adam-17

INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15.

ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.

KP-457 is a specific inhibitor of a disintegrin-metalloproteinase 17 (ADAM17) and a TNFα converting enzyme TACE inhibitor that blocks the production of soluble TNF (sTNF).

JG26 is a potent inhibitor of ADAM17, which can inhibit ADAM8, ADAM17, ADAM10 and MMP-12, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM, respectively, and can be used to study the immune system of the body.

TMI-1 (WAY-171318), a novel orally active inhibitor of ADAM17 (TACE) and MMP, induces tumor apoptosis in a breast cancer.

GW280264X (Carbamic acid) is an inhibitor of ADAM17 .

IK-862 is a selective inhibitor of TACE (ADAM17).

ADAM17-IN-1 is a selective ADAM17 inhibitor. It functions by reducing dendritic cell (DC) metabolic activity through ADAM17 inhibition, thereby impairing DC antigen presentation, suppressing allergen-specific Th2 cell polarization, and decreasing the secretion of Th2 cytokines (IL-4, IL-5, IL-13). In mouse models of house dust mite (HDM)-induced type 2/eosinophilic airway inflammation, ADAM17-IN-1 demonstrates protective effects. This compound can be utilized in research on type 2 hyperreactive allergic asthma.

TAPI-1, an ADAM17/TACE inhibitor, inhibits shedding of cytokine receptors.

Anti-ADAM17 Antibody is an antibody targeting ADAM17. It can be used for tumor microenvironment, fibrosis, and inflammation research.

MEDI-3622 is an antibody targeting ADAM17. It can be used for tumor microenvironment, fibrosis, and inflammation research.

Anti-ADAM17 Antibody 2 is an antibody targeting ADAM17. It can be used for tumor microenvironment, fibrosis, and inflammation research.

ADAMTS7-IN-1 (Compound 3a) serves as a potent and selective ADAMTS7 inhibitor, exhibiting a K i value of 9 nM. It is primarily utilized in atherosclerosis research.

ADAM-17 (TACE) and MMP inhibitor; attenuates TNF-α processing. Acts in concert with GM6001 to inhibit Chlamydia trachomatis growth.

ADAM-17 (TACE) and MMP inhibitor (Ki = 120 nM at ADAM-17). Sensitizes cancer stem cells to the lethal effects of 5-FU in vitro. Blocks shedding of TNF-α from cell membranes.