a-cyclodextrin

Hydroxypropyl-beta-cyclodextrin, also known as Hydroxypropyl-beta-cyclodextrin; THPB; HP-beta-CD; HPbCD; HP-beta-CyD; VTS-270; HPbetaCD; HPbetaCyD, is a drug candidate potentially for the treatment of Niemann-Pick type C diseases. In April 2009, hydroxypr

α-Cyclodextrin (Alfadex) is a soluble fiber derived from corn and has beneficial effects on weight management in obese individuals with type 2 diabetes.

SBE-β-CD (Sulfobutylether-β-Cyclodextrin) is a β-cyclodextrin derivative with a sodium sulfonate salt separated from the lipophilic cavity by a butyl ether spacer group, or sulfobutylether. SBE-β-CD is widely used as a co-solvent in biological experiments.

γ-Cyclodextrin (Ringdex C) is a cycloamylose composed of eight alpha-(1->4) linked D-glucopyranose units found in some foods.

β-Cyclodextrin (NSC 269471) is a member of the class of compounds known as oligosaccharides.

Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a macrocyclic compound utilized as a solubilizer for hydrophobic substances in biological studies, and serves as a lipid raft inhibitor with cholesterol-lowering and potential antitumor activities.

HP-β-CD (HP-β-CD) is a widely used drug delivery vehicle to improve stability and bioavailability.

Mal-β-CD, a cellular cholesterol modifier, forms a soluble inclusion complex with cholesterol.

3A-Amino-3A-deoxy-(2AS,3AS)-α-cyclodextrin is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Hexakis (2,3,6-tri-O-methyl)-α-cyclodextrin is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

3A-Amino-3A-deoxy-(2AS,3AS)-γ-cyclodextrin is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Mono-6-O-(p-toluenesulfonyl)-α-cyclodextrin is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Mono-2-O-(p-toluenesulfonyl)-α-cyclodextrin is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Mono-2-O-(p-toluenesulfonyl)-γ-cyclodextrin is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Mono-6-O-(p-toluenesulfonyl)-γ-cyclodextrin is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

3A-Amino-3A-deoxy-(2AS,3AS)-β-cyclodextrin is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

Sugammadex sodium (Org25969) , a synthetic derivative of γ-cyclodextrin, is a steroid-based neuromuscular blocker reversing agent.

Limaprost alfadex is an oral medicine for the circulatory system (for confinement-related thromboangiitis ulcer, anaphrodisia, sharp pain and ischemia characteristics symptom, the improvement of subjective symptom and walking ability with postnatal lumbar

α-Cyclodextrin (α-CD) is a saccharide comprised of six glucose subunits linked by α-1,4 bonds, which results in a cone-shaped molecule.1It contains a hydrophobic interior and hydrophilic exterior, which allow it to form inclusion complexes with wide variety of molecules, conferring enhanced solubility and stabilization to the molecules. α-CD has commonly been used in the separation and purification of chemicals on an industrial scale.1,2Formulations containing α-CD have been used in the pharmaceutical industry to improve the physical and chemical properties of compounds, the food industry as flavor carriers and stabilizers in processed and ultra-processed foods and certain beverages, as well as in other industrial applications. 1.Li, S., and Purdy, W.C.Cyclodextrins and their applications in analytical chemistryChem. Rev.92(6)1457-1470(1992) 2.Astray, G., Gonazalez-Barreiro, C., Mejuto, J.C., et al.A review on the use of cyclodextrins in foodsFood Hydrocolloids23(7)1631-1640(2009)

Cho-Arg is a steroid-based cationic lipid that contains a cholesterol skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratios greater than or equal to 4. Cho-Arg facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence or absence of fetal bovine serum, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the caveolae-mediated endocytosis inhibitor genistein . It is cytotoxic to H1299 cells (IC50 = 88.5 μg/ml).

Dios-Arg is a steroid-based cationic lipid that contains a diosgenin skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratio greater than or equal to 4. Dios-Arg facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence and absence of fetal bovine serum, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the caveolae-mediated endocytosis inhibitor genistein . It has been used, coupled to 1,2-dioleoyl-sn-glycero-3-PE , to bind siRNA and plasmid DNA to form cationic lipid nanoparticles for intracellular transport. Dios-Arg is cytotoxic to H1299 and HeLa cells (IC50s = 83.5 and 74.1 μg/ml, respectively).

2H-Cho-Arg is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection. It forms a complex with plasmid DNA (pDNA) and decreases pDNA migration in an electrophoretic mobility shift assay at +/- charge ratios of 4 or higher. 2H-Cho-Arg facilitates transfection of a luciferase gene into H1299 cells, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the caveolae-mediated endocytosis inhibitor genistein , but not by inhibitors of clathrin- or micropinocytosis-mediated endocytosis. It induces cytotoxicity in H1299 cells (IC50 = 92.7 μg/ml).

6-O-Sulfo-β-cyclodextrin is a sulfated cyclodextrin.1It has been used for the chiral separation of nadolol racemates by capillary electrophoresis. 1.Wang, F., Dowling, T., Bicker, G., et al.Electrophoretic chiral separation of pharmaceutical compounds with multiple stereogenic centers in charged cyclodextrin mediaJ. Sep. Sci.24(5)378-384(2001)