a-7 hydrochloride

A-7 hydrochloride is a calmodulin antagonist and causes alterations in the subpopulation of CD44+CD24- in MDA-MB-231 cells.

PKRA83 (PKRA7) hydrochloride is a potent prokinetic (PK2) antagonist capable of crossing the blood-brain barrier, competitively inhibiting PK2 from binding to its receptors PKR1 and PKR2. It effectively suppresses PK2 receptors, with IC50 values of 5.0 nM for PKR1 and 8.2 nM for PKR2, and exhibits anticancer, anti-arthritis, and anti-angiogenic activities.

PKRA83 hydrochloride hydrate, also known as PKRA7, is a potent prokineticin (PK2) antagonist that competes with PK2 for binding to its receptors, PKR1 and PKR2. It exhibits high inhibitory affinity with IC50 values of 5.0 nM for PKR1 and 8.2 nM for PKR2, displaying anticancer, anti-arthritis, and anti-angiogenic properties. Additionally, this compound is capable of crossing the blood-brain barrier [1] [2] [3].

CRA-026440 hydrochloride is a potent and broad-spectrum HDAC inhibitor. CRA-026440 hydrochloride exhibits Ki values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are 4 nM, 14 nM, 11 nM, 15 nM, 7 nM, and 20 nM, respectively. CRA-026440 hydrochloride exhibits antitumor and antiangiogenic activities.

TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively).

KAPA hydrochloride (7-keto-8-Aminopelargomic Acid HCl) is a biotin synthesis intermediate.

Methyl thiazolidine-2-carboxylate hydrochloride ,with CAS No. 33305-08-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Methyl thiazolidine-2-carboxylate hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-AMinoMethyl-3-fluoropyridine hydrochloride, with CAS No. 312904-49-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-AMinoMethyl-3-fluoropyridine hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4-Methoxybenzamidine hydrochloride ,with CAS No. 51721-68-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-Methoxybenzamidine hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

L-homophenylalanine ethyl ester hydrochloride ,with CAS No. 90891-21-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. L-homophenylalanine ethyl ester hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Irinotecan Hydrochloride (CPT-11 hydrochloride) is the hydrochloride salt of a semisynthetic derivative of camptothecin. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent.

Demeclocycline hydrochloride (Declomycin) is a TETRACYCLINE analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than TETRACYCLINE, it maintains effective blood levels for longer periods of time.

7-Methoxyquinoline Hydrochloride is a chemical derivative of quinoline, a heterocyclic aromatic organic compound.

Regorafenib Hydrochloride (BAY73-4506 hydrochloride) is a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity

4-(3-Bromophenyl)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride ,with CAS No. 543739-81-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-(3-Bromophenyl)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

3,4-Dichlorophenylhydrazine hydrochloride ,with CAS No. 19763-90-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 3,4-Dichlorophenylhydrazine hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4-(1-pyrrolidinylmethyl)benzoic acid hydrochloride, with CAS No. 193968-71-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-(1-pyrrolidinylmethyl)benzoic acid hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

(4-Chlorophenyl)(4-piperidyl)methanone hydrochloride ,with CAS No. 55695-51-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. (4-Chlorophenyl)(4-piperidyl)methanone hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-[(3-Chlorobenzyl)thio]-4,5-dihydro-1H-imidazole hydrochloride ,with CAS No. 258347-64-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2-[(3-Chlorobenzyl)thio]-4,5-dihydro-1H-imidazole hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4-[4-Phenyl-3,6-dihydro-1(2H)-pyridinyl]butanoic acid hydrochloride ,with CAS No. 60926-04-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-[4-Phenyl-3,6-dihydro-1(2H)-pyridinyl]butanoic acid hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1,7,7-Trimethylbicyclo[2.2.1]heptan-2-amine hydrochloride ,with CAS No. 32768-19-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1,7,7-Trimethylbicyclo[2.2.1]heptan-2-amine hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

1-(2,3-Dihydro-1-benzofuran-2-yl)methanamine hydrochloride ,with CAS No. 19997-54-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-(2,3-Dihydro-1-benzofuran-2-yl)methanamine hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2,1,3-Benzothiadiazol-4-ylmethylamine hydrochloride ,with CAS No. 830330-21-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 2,1,3-Benzothiadiazol-4-ylmethylamine hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

7-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE, with CAS No. 799274-06-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 7-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.