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PKRA83 hydrochloride
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Catalog No. T212408
Alias PKRA7 hydrochloride
PKRA83 (PKRA7) hydrochloride is a potent prokinetic (PK2) antagonist capable of crossing the blood-brain barrier, competitively inhibiting PK2 from binding to its receptors PKR1 and PKR2. It effectively suppresses PK2 receptors, with IC50 values of 5.0 nM for PKR1 and 8.2 nM for PKR2, and exhibits anticancer, anti-arthritis, and anti-angiogenic activities.
PKRA83 hydrochloride
PKRA83 hydrochloride
😃Good
Catalog No. T212408Alias PKRA7 hydrochloride
PKRA83 (PKRA7) hydrochloride is a potent prokinetic (PK2) antagonist capable of crossing the blood-brain barrier, competitively inhibiting PK2 from binding to its receptors PKR1 and PKR2. It effectively suppresses PK2 receptors, with IC50 values of 5.0 nM for PKR1 and 8.2 nM for PKR2, and exhibits anticancer, anti-arthritis, and anti-angiogenic activities.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
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| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | PKRA83 (PKRA7) hydrochloride is a potent prokinetic (PK2) antagonist capable of crossing the blood-brain barrier, competitively inhibiting PK2 from binding to its receptors PKR1 and PKR2. It effectively suppresses PK2 receptors, with IC50 values of 5.0 nM for PKR1 and 8.2 nM for PKR2, and exhibits anticancer, anti-arthritis, and anti-angiogenic activities. |
| In vitro | PKRA83 (1 µg/mL) hydrochloride effectively reduces microvascular endothelial cell branching induced by PK2 in vitro. Additionally, PKRA83 (2 μM, 24 hours) hydrochloride inhibits the neuroprotective effect of rPK2 in dopaminergic N27 cells, preventing rPK2 from safeguarding N27 cells against MPP+-induced dopaminergic neuronal cell death. |
| In vivo | PKRA83 (20 mg/kg; IP) hydrochloride exhibits antitumor activity in a glioblastoma xenograft tumor model. Additionally, PKRA83 (15 mg/kg; intraperitoneal injection, administered once daily for two weeks) hydrochloride is effective in suppressing arthritis in mice with collagen-induced arthritis. |
| Synonyms | PKRA7 hydrochloride |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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