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Results for "

Polycystic

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    17
    TargetMol | Inhibitors_Agonists
  • Natural Products
    1
    TargetMol | Natural_Products
  • Recombinant Protein
    1
    TargetMol | Recombinant_Protein
  • Cell Research
    1
    TargetMol | Inhibitors_Agonists
Cancer-Targeting Compound 1
T135721007581-62-5In house
Cancer-Targeting Compound 1 can be used in the study of hormone-related cancers, including the treatment or prevention of fibroids, uterine leiomyomas, polycystic ovarian syndrome, or hormone-dependent Cancer, among others.
  • Inquiry Price
6-8weeks
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TargetMol | Inhibitor Sale
BLU2864
T601702810747-89-6In house
BLU2864 is an orally active, highly selective, ATP-competitive PRKACA inhibitor with an IC50 of 0.3 nM, exhibiting anti-tumor activity and potential applications in cancer and polycystic kidney disease research [1] [2].
  • Inquiry Price
10-14 weeks
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Clomesone
T5008688343-72-0
Clomesone is a synthetic non-steroidal drug that can be used as a molecular structural unit. It is a drug commonly used to treat female infertility and works by blocking the action of estrogen in the brain. It has been shown to be effective in inducing ovulation in women suffering from polycystic ovary syndrome and other infertility problems.
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TargetMol | Inhibitor Sale
(R)-BPO-27
T10591L1415390-47-4
(R)-BPO-27 is an orally active and potent ATP-competitive CFTR inhibitor (IC50: 4 nM) for the study of diarrhoea and polycystic kidney.
  • Inquiry Price
7-10 days
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PPQ-102
PPQ102, CFTR Inhibitor, PPQ 102
T1874931706-15-9
PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).
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BSc5367
BSc 5367
T2013893029584-84-4
BSc5367 is a potent inhibitor of the structural domain of Nek1 kinase with an IC50=11.5 nM. Nek1 is a NIMA-associated protein kinase tightly linked to cell cycle regulation, DNA repair, and microtubule regulation. BSc5367 can be used in studies related to amyotrophic lateral sclerosis (ALS), polycystic kidney disease (PKD), and several types of radiotherapy-resistant cancers.
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AV457
T2042852713387-11-0
AV457 is a potent and selective inhibitor of mTOR. It effectively suppresses cyst growth in polycystic kidney disease (PKD) organoids. AV457 reduces the protein expression of P-s6 and P-p70s6, but it does not decrease the protein expression of P-AKT.
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Steviol
NSC 226902, Hydroxydehydrostevic acid
T2S1837471-80-7
1. Steviol (NSC-226902), a natural sweetener, it inhibits proliferation of the gastrointestinal cancer cells intensively. 2. Steviol can induce a significant increase in CYP3A29 expression. 3. Steviol inhibits the proliferation of the human osteosarcoma U2OS cell line in a dose- and time-dependent manner. 4. Steviol can treat polycystic kidney disease, it slowed cyst growth, in part, by reducing AQP2 transcription, promoted proteasome, and lysosome-mediated AQP2 degradation.
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7-10 days
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Ibiglustat succinate
GZ402671succinate,Venglustat succinate,Ibiglustat succinate,SAR402671succinate
T391051629063-80-4
Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant inhibitor of glucosylceramide synthase (GCS) utilized in the investigation of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.
    7-10 days
    Inquiry
    gfb-12811
    GFB12811
    T626952775311-17-4
    GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.
    • Inquiry Price
    10-14 weeks
    Size
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    Vasopressin V2 receptor antagonist 1
    T641742648650-50-2
    Vasopressin V2 receptor antagonist 1 (Compound 4g) is a vasopressin V2 receptor (V2R) antagonist with a Ki of 3.8 nM, used in the treatment of autosomal dominant polycystic kidney disease (ADPKD).
    • Inquiry Price
    6-8 weeks
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    Chlormadinone (free base)
    T719041961-77-9
    Chlormadinone (free base) is a synthetic steroid hormone and antagonist at androgen and estrogen receptors used to treat BPH and polycystic ovary syndrome. It also promotes osteoblast differentiation and Ca deposition in bone marrow stem cells.
    • Inquiry Price
    6-8 weeks
    Size
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    cdk7-in-20
    T73163
    CDK7-IN-20 is a potent, selective, and irreversible inhibitor of Cyclin-Dependent Kinase 7 (CDK7) with an IC50 value of 4 nM, exhibiting over 206-fold selectivity against related kinases [CDK1, CDK2, CDK3, CDK5, CDK6, CDK9, and CDK12]. It holds potential for research into autosomal dominant polycystic kidney disease (ADPKD).
    • Inquiry Price
    6-8 weeks
    Size
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    SBI-115
    T7428882366-16-7
    SBI-115 is an antagonist of TGR5. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5
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    CYP4A11/CYP4F2-IN-2
    T861512280834-99-1
    CYP4A11 CYP4F2-IN-2 (compound 15) serves as an orally administered inhibitor targeting CYP4A11 4F2, exhibiting IC50 values of 120 nM and 220 nM, respectively. This compound effectively suppresses 20-HETE production within the rat kidney and shows promise in mitigating the progression of diabetic nephropathy and autosomal dominant polycystic kidney disease [1].
    • Inquiry Price
    10-14 weeks
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    endo CNTinh-03
    T88553345288-49-5
    Endo CNTinh-03 effectively inhibits the increase of cAMP and cGMP triggered by agonists such as G protein-coupled receptors, adenylate cyclase, and guanylate cyclase, with an IC50 of 4 μM. It also blocks the chloride ion currents induced by cholera toxin and Escherichia coli (STa) toxins, alleviates secretory diarrhea in mouse models, and prevents cyst growth in models of polycystic kidney disease.
    • Inquiry Price
    10-14 weeks
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    Cyclohexane-1,2,3,4,5,6-hexaol
    TYD-006926917-35-7
    Cyclohexane-1,2,3,4,5,6-hexaol, also known as inositol or Inositol, is a cyclic sugar alcohol characterized by a six-carbon ring with six hydroxyl groups. This compound is significant for its biological activity and is widely found in nature, particularly in plant and animal tissues. It plays roles in various physiological processes such as signal transduction, osmoregulation, and lipid metabolism. Moreover, Cyclohexane-1,2,3,4,5,6-hexaol has potential research applications, including improving conditions related to insulin resistance, polycystic ovary syndrome, and mental health issues. It is also used as a supplement in animal feed and human nutrition products.
    • Inquiry Price
    7-10 days
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