polycystic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2S1837	Steviol	NSC 226902,Hydroxydehydrostevic acid	Others
	1. Steviol (NSC-226902), a natural sweetener, it inhibits proliferation of the gastrointestinal cancer cells intensively. 2. Steviol can induce a significant increase in CYP3A29 expression. 3. Steviol inhibits the prolif...		Others
T1874	PPQ-102	PPQ102,CFTR Inhibitor,PPQ 102	CFTR , Autophagy
	PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).		CFTR , Autophagy
T10591L	(R)-BPO-27		CFTR , Autophagy
	(R)-BPO-27 is an orally active and potent ATP-competitive CFTR inhibitor (IC50: 4 nM) for the study of diarrhoea and polycystic kidney.		CFTR , Autophagy
T7428	SBI-115		GPCR19
	SBI-115 is an antagonist of TGR5. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5		GPCR19
T13572	Cancer-Targeting Compound 1		Others
	Cancer-Targeting Compound 1 can be used in the study of hormone-related cancers, including the treatment or prevention of fibroids, uterine leiomyomas, polycystic ovarian syndrome, or hormone-dependent Cancer, among othe...		Others
T60170	BLU2864		Others
	BLU2864 is an orally active, highly selective, ATP-competitive PRKACA inhibitor with IC 50 of 0.3 nM. BLU2864 exhibits anti-tumor activity. BLU2864 has potential to be used in cancer and polycystic kidney disease researc...		Others
T16114	Pavinetant	AZD4901,MLE-4901,AZD2624	MEK
	Pavinetant is a small molecule orally active and selective neurokinin-3 (NK3) receptor antagonist for the treatment of hot flashes and polycystic ovarian syndrome (PCOS), which is a potential compound for the treatment o...		MEK
T50086	Clomesone		Others
	Clomesone is a synthetic non-steroidal drug that can be used as a molecular structural unit. It is a drug commonly used to treat female infertility and works by blocking the action of estrogen in the brain. It has been s...		Others
T71904	Chlormadinone (free base)
	Chlormadinone (free base) is a synthetic steroid hormone and antagonist at androgen and estrogen receptors used to treat BPH and polycystic ovary syndrome. It also promotes osteoblast differentiation and Ca deposition in...
T39105	Ibiglustat succinate	GZ402671succinate,Venglustat succinate,Ibiglustat succinate,SAR402671succinate
	Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant inhibitor of glucosylceramide synthase (GCS). It is utilized in the investigation of Gaucher disease type 3, Parkinson's disease associated with GBA ...
T64174	Vasopressin V2 receptor antagonist 1
	Vasopressin V2 receptor antagonist 1 (Compound 4g) is a vasopressin V2receptor (V2R) antagonist (Ki: 3.8 nM). dominant polycystic kidney disease (ADPKD).
T39712	RGLS4326	RG4326,RGLS4326
	RGLS4326 (RG4326) is a short oligonucleotide inhibitor of microRNA-17 (miR-17), with a pioneering role in its class. This compound, with a research focus on autosomal dominant polycystic kidney disease (ADPKD), effective...
T61362	CDK5-IN-3
	CDK5-IN-3 (compound 11) is a highly potent and selective inhibitor of CDK5, demonstrating significant inhibition with IC50 values of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. This compound holds promise ...
T73163	CDK7-IN-20
	CDK7-IN-20 is a potent, selective, and irreversible inhibitor of Cyclin-Dependent Kinase 7 (CDK7) with an IC50 value of 4 nM, exhibiting over 206-fold selectivity against related kinases CDK1, CDK2, CDK3, CDK5, CDK6, CDK...
T60953	BSc5367
	BSc5367 is a potent inhibitor for the Nek1 kinase domain with an IC50 value of 11.5 nM. Nek1 is a NIMA-related protein kinase that crucially involved in cell cycle regulation, DNA repair and microtubule regulation. The N...