j2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7265	HSP27 inhibitor J2	J2	HSP
	HSP27 inhibitor J2 (J2) (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function.		HSP
T11476	GSK-J2		Others
	GSK-J2, an isomer of GSK-J1, haven't any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A.		Others
T73782	Prostaglandin J2
	Prostaglandin J2 (PGJ2), a derivative of Prostaglandin D2 (PGD2), serves as a potent agonist for PGD2 receptors (DP), exhibiting affinity constants (K i) of 0.9 nM and 6.6 nM for hDP and hCRTH2 receptors, respectively. I...
T22473	15-deoxy-Δ-12,14-Prostaglandin J2		Others
	15-deoxy-Δ-12,14-Prostaglandin J2 is a PPARγ agonist.		Others
T68587	Oxmetidine mesylate
	Oxmetidine mesylate is an antagonist to Histamine H2 Receptors
T77644	AJ2-30		Others
	AJ2-30 is an SLCl5A4 inhibitor that inhibits TLR9-mediated B cell activation and inhibits MDP transporter.AJ2-30 inhibits endogenous NOD signaling in human and mouse macrophages.AJ2-30 can be used for the study of inflam...		Others
T11701	J22352		Caspase
	J22352, a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM, enhances anticancer effects in glioblastoma by promoting HDAC6 degradation. It does so by inhibiti...		Caspase
T69572	UAWJ248
	UAWJ248 is a SARS-CoV-2 Protease inhibitor. UAWJ248 provides new directions for the development of Mpro inhibitors as SARS-CoV-2 antivirals.
T80760	XSJ2-46		Influenza Virus
	XSJ2-46, a 5'-amino NI analog, is an antiviral agent possessing anti-Zika virus properties and demonstrates reasonable inhibition of RNA-dependent RNA polymerases (RdRp), with an IC50 of 8.78 μM [1].		Influenza Virus
T83152	AJ2-71
	AJ2-71 is a SLC15A4 inhibitor that suppresses IFN-α production and obstructs SLC15A4-mediated MDP transport, making it suitable for research of inflammation [1].
T70690	UAWJ246
	UAWJ246 is a SARS-CoV-2 Protease inhibitor (IC50 = 45 nM). UAWJ246 provides new directions for the development of Mpro inhibitors as SARS-CoV-2 antivirals.
T22881	JNJ28871063 hydrochloride	JNJ 28871063 hydrochloride	Others
	ErbB receptor family inhibitor		Others
T80432	δ-Buthitoxin-Hj2a		Sodium Channel
	δ-Buthitoxin-Hj2a, a potent scorpion-venom peptide, acts as a NaV1.1 agonist with an EC50 value of 32 nM and is employed in Dravet syndrome (DS) research [1].		Sodium Channel
T79543	J27644		HDAC
	J27644 is a potent HDAC (histone deacetylase) inhibitor that mitigates TGF-β (transforming growth factor beta)-induced pulmonary fibrosis [1].		HDAC
T15277	Fervenulin		Parasite
	Fervenulin is isolated from a nematicidal actinomycete Streptomyces sp. CMU-MH021 with nematicidal activity. It also inhibits egg hatch and J2 mortality of M. incognita (MICs: 30 μg/mL and 120 μg/mL, respectively).		Parasite
TN3050	4'-Methoxyflavanone		Others
	4'-Methoxyflavanone is a flavonoid isolated from natural Isaria fumosorosea KCH J2, which is used in the study of metabolic and cardiovascular diseases.		Others
TN5788	Phyllostine
	Phyllostine appears to be their more immediate precursor, since PCMB-treated extracts of J2 converted Phyllostine but not isoepoxydon to these new metabolites.
T22820	GSK J5 HCl (1394854-51-3 free base)	GSK J5 HCl	Others
	GSK J5 HCl is the hydrochloride form of GSK J5. GSK J5 is an inactive isomer of GSK J4 and a cell-permeable ester derivative of inactive control GSK J2.		Others
T36180	Azelaoyl PAF
	Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPARγ. One of these substances was recently isolated and pur...
T35551	Gallocyanine
	Gallocyanine is a small molecule blue dye used to stain nuclei. It is known to inhibit Dickkopf-1 (Dkk1), an antagonist of the Wnt pathway. Gallocyanine can disrupt the interaction of Dkk1 with its receptor LRP5/6 (IC50 ...