J2

HSP27 inhibitor J2 (J2) (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function.

GSK-J2 is an inactive enantiomer of GSK-J1 that is lipophilic and serves as an inactive control for GSK-J21.

15-Deoxy-Δ12,14-Prostaglandin J2-2-glyceryl ester is a derivative of 15-Deoxy-Δ-12,14-prostaglandin J2. The 15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. This compound acts as a selective PPARγ (with an EC50 of 2 µM) and covalent PPARδ agonist. Additionally, 15-Deoxy-Δ-12,14-prostaglandin J2 effectively promotes the differentiation of C3H10T1/2 fibroblasts into adipocytes, with an EC50 of 7 μM.

15-deoxy-Δ-12,14-Prostaglandin J2 is a PPARγ agonist.

Prostaglandin J2 (PGJ2), a derivative of Prostaglandin D2 (PGD2), serves as a potent agonist for PGD2 receptors (DP), exhibiting affinity constants (K i) of 0.9 nM and 6.6 nM for hDP and hCRTH2 receptors, respectively. It activates cyclic AMP production with an EC50 of 1.2 nM, induces oxidative stress, neuronal apoptosis, and promotes the accumulation of ubiquitinated (Ub) proteins. Notably, PGJ2's neurotoxic properties are implicated in the progression of neurodegenerative diseases such as Alzheimer's (AD) and Parkinson's (PD) [1] [2] [3] [4].

GSK-J2 sodium, the sodium form of GSK-J2, is an isomer of GSK-J1 and lacks specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A [1].

13,14-Dihydro-15-keto prostaglandin J2 (13,14-Dihydro-15-keto-PGJ2) is the dehydrated product of 13,14-dihydro-15-keto PGD2.

15-deoxy-Δ12,14-Prostaglandin J2 Glutathione (15-Deoxy-Δ12,14-PGJ2 Glutathione) is a non-enzymatic adduct formed from the reaction of 15-deoxy-Δ12,14-PGJ2 with glutathione. The biological properties of this compound have not yet been determined.

15-Deoxy-Δ12,14-prostaglandin J2 serinol amide (15-Deoxy-Δ12,14-PGJ2 serinol amide) is a derivative of 15-deoxy-Δ12,14-PGJ2-2-glycerol ester.

J22352, a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM, enhances anticancer effects in glioblastoma by promoting HDAC6 degradation. It does so by inhibiting autophagy and stimulating the antitumor immune response, further restoring host antitumor activity through the reduction of PD-L1's immunosuppressive activity.

SJ26 is a Wnt1 inhibitor known for its anticancer activity. It inhibits the expression of WNT1 and the downstream signaling pathways mediated by WNT1 in a G-quadruplex structure-dependent manner, thereby suppressing the migratory activity of cancer cells.

MJ210 is an orally active and blood-brain barrier-permeable modulator of the NF-κB and MAPK pathways, exhibiting neuroprotective properties. In vitro, 5 μM MJ210 can increase the survival rate of rotenone-treated SH-SY5Y cells to 81.9% and reduce levels of ROS. In vivo, 5 mg/kg MJ210 improves motor dysfunction in rat models of Parkinson's disease. MJ210 is useful for research in neurological disorders, including Parkinson's disease.

ErbB receptor family inhibitor

UAWJ248 is a SARS-CoV-2 Protease inhibitor. UAWJ248 provides new directions for the development of Mpro inhibitors as SARS-CoV-2 antivirals.

UAWJ246 is a SARS-CoV-2 Protease inhibitor (IC50 = 45 nM). UAWJ246 provides new directions for the development of Mpro inhibitors as SARS-CoV-2 antivirals.

AJ2-30 is an SLCl5A4 inhibitor that inhibits TLR9-mediated B cell activation and inhibits MDP transporter.AJ2-30 inhibits endogenous NOD signaling in human and mouse macrophages.AJ2-30 can be used for the study of inflammation.

J27644 is a potent HDAC (histone deacetylase) inhibitor that mitigates TGF-β (transforming growth factor beta)-induced pulmonary fibrosis [1].

δ-Buthitoxin-Hj2a, a potent scorpion-venom peptide, acts as a NaV1.1 agonist with an EC50 value of 32 nM and is employed in Dravet syndrome (DS) research [1].

XSJ2-46, a 5'-amino NI analog, is an antiviral agent possessing anti-Zika virus properties and demonstrates reasonable inhibition of RNA-dependent RNA polymerases (RdRp), with an IC50 of 8.78 μM [1].

AJ2-71 is a SLC15A4 inhibitor that suppresses IFN-α production and obstructs SLC15A4-mediated MDP transport, making it suitable for research of inflammation [1].

Anti-Mouse Jagged 2 Antibody (HMJ2-1) is an IgG antibody inhibitor derived from American hamster, specifically targeting mouse Jagged 2.

CJ28 is an inhibitor of cortisol biosynthesis, significantly suppressing both basal and stimulated cortisol production in human adrenal carcinoma cell lines. It exerts its inhibitory effects by reducing steroidogenesis and de novo cholesterol biosynthesis.

Microcin J25 (MccJ25) is a cyclopeptide antibiotic made up of 21 unmodified amino acid residues. It effectively inhibits the DNA-dependent RNA polymerase (RNAP) of Gram-negative bacteria and exhibits antibacterial activity.

THJ2201 N-pentanoic acid metabolite belongs to synthetic cannabinoid metabolites. It is a metabolite of THJ2201.