dhfr — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3693	DHFR-IN-3	7-bromoquinazoline-2,4-diamine	Others
	DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) is an active biochemical.		Others
T61486	DHFR-IN-4		DHFR
	DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with anti-tumour activity, inhibits EGFR and HER2 and can be used to study pancreatic cancer.		DHFR
T4197	HZ-1157	HZ1157,DHFR-inhibitor	HCV Protease
	HZ-1157 (DHFR-inhibitor) is a hepatitis C virus (HCV) inhibitor with inhibitory activities toward HCV NS3/4A protease.		HCV Protease
T79734	DHFR-IN-8
	DHFR-IN-8 (compound 6r), a dihydrofolate reductase (DHFR) inhibitor, disrupts purine and thymidylate biosynthesis critical for cell proliferation and growth. This compound effectively suppresses methicillin-resistant Sta...
T82571	DHFR-IN-10
	DHFR-IN-10 (compound 4c) is a potent inhibitor of dihydrofolate reductase (DHFR), displaying an inhibition concentration half-maximum (IC50) of 4.21 μM against Mycobacterium tuberculosis DHFR enzyme and demonstrates stro...
T79735	DHFR-IN-9
	DHFR-IN-9 (compound 8A), a dihydrofolate reductase (DHFR) inhibitor, impedes purine and thymidylate biosynthesis, pivotal in cell proliferation and growth. It demonstrates potency against methicillin-resistant Staphyloco...
T82570	DHFR-IN-11
	DHFR-IN-11 (compound 6b) is a DHFR inhibitor with demonstrated inhibitory efficacy against the M. tuberculosis DHFR enzyme, reflected in an IC50 value of 5.70 μM [1].
T73328	DHFR-IN-5
	DHFR-IN-5, an orally active and potent inhibitor of dihydrofolate reductase (DHFR), exhibits a K_i value of 0.54 nM against the quadruple mutant Plasmodium falciparum DHFR, demonstrating anti-malarial activity.
T63379	DHFR-IN-1
	DHFR-IN-1 is a selective and potent inhibitor of DHFR (dihydrofolate reductase) (IC50: 40.71 nM). DHFR-IN-1 exhibited some antifungal activity and good antibacterial activity against Gram-positive and Gram-negative bacte...
T60286	DHFR-IN-2
	DHFR-IN-2 (compound 4e) is a potent and uncompetitive inhibitor for MtDHFR with an IC 50 of 7 μM. The enzyme dihydrofolate reductase from M.tuberculosis (MtDHFR) has a high unexploited potential to be a target for new dr...
T61489	VEGFR-2/DHFR-IN-1
	VEGFR-2/DHFR-IN-1 (compound 8b) is a chemical inhibitor targeting VEGFR-2 and DHFR, exhibiting IC50 values of 0.384 μM and 7.881 μM, respectively. It demonstrates effective antibacterial properties against a range of pat...
T61229	VEGFR-2/DHFR-IN-2
	VEGFR-2/DHFR-IN-2 (compound 5b) is a dual inhibitor targeting VEGFR-2 and DHFR, with respective IC50 values of 0.623 μM and 9.085 μM. It demonstrates potent cytotoxicity against C26, HepG2, and MCF7 cancer cell lines, wi...
T82493	EGFR/HER2/DHFR-IN-2		EGFR
	EGFR/HER2/DHFR-IN-2 (Compound 4b) serves as an inhibitor for EGFR, HER2, and DHFR, with IC50 values of 0.248, 0.156, and 0.138 μM, respectively. It exhibits anticancer activity, displaying IC50 values of 9.14, 7.33, 14.1...		EGFR
T82492	EGFR/HER2/DHFR-IN-3		EGFR
	EGFR/HER2/DHFR-IN-3 (compound 4c) serves as an efficacious dual inhibitor specifically targeting EGFR/HER2, exhibiting IC50 values of 0.138 μM for EGFR and 0.092 μM for HER2, respectively. Moreover, it demonstrates inhi...		EGFR
T61596	EGFR/HER2/DHFR-IN-1
	EGFR/HER2/DHFR-IN-1 is a highly selective and potent anticancer compound specifically targeting MCF-7 breast cancer cells. It acts as a multi-inhibitor, targeting the EGFR/HER2 kinase and DHFR enzymes, with IC50 values o...
T36692	Fanotaprim		DHFR
	Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor. Fanotaprim inhibits the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM and a hDHFR IC50 of 308 ± 71 nM and a hDHFR to TgDHFR selectivity ratio o...		DHFR
T81381	PROTAC eDHFR Degrader-1		PROTACs
	PROTAC eDHFR Degrader-1 is a potent degrader targeting eDHFR-YFP and various proteins of interest (POIs), such as YFP and Luciferase [1].		PROTACs
T0849	Pyrimethamine	Pirimecidan,RP 4753,Pirimetamin	DHFR , Antifolate , Parasite
	Pyrimethamine (Pirimecidan) is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.		DHFR , Antifolate , Parasite
T6226	Pemetrexed disodium hemipenta hydrate	Pemetrexed Disodium Hydrate,LY-231514 Disodium Hydrate,Pemetrexed sodium hydrate	Apoptosis , DHFR , DNA/RNA Synthesis , Antifolate , Autophagy
	Pemetrexed disodium hemipenta hydrate (LY-231514 Disodium Hydrate) is a new-type antifolate and antimetabolite for TS, DHFR, and GARFT. The Ki of Pemetrexed Disodium Hydrate for TS, DHFR and GARFT is 1.3 nM, 7.2 nM and 6...
T1485	Methotrexate	NCI-C04671,WR19039,Amethopterin,CL14377	Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate
	Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and v...		Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate
T61159	Antibacterial agent 26		Antibacterial
	Antibacterial agent 26 is an antimicrobial compound that is a potent DHFR inhibitor (S. aureus DHFR Ki of 0.020 nM).		Antibacterial
T19858	Brodimoprim		DHFR , Antibacterial
	Brodimoprim is an inhibitor of dihydrofolate reductase(DHFR). Brodimoprim is also a long-acting broad-spectrum antibacterial agent characterized by a good pharmacokinetic profile.		DHFR , Antibacterial
T64295	Talotrexin ammonium		DHFR
	Talotrexin ammonium is a non-polyglutamic acid antifolate. Talotrexin ammonium inhibits tumor growth by targeting dihydrofolate reductase (DHFR), thereby improving anti-tumor activity in a wide range of cancer models, he...		DHFR
T2204	Diaveridine	EGIS-5645,CCRIS-3784,AI3-23935	DHFR , Antifolate , Antibacterial
	Diaveridine (AI3-23935) (DVD) is a popular antibacterial synergist that is widely used in combination with sulfonamide. It has been reported to be genotoxic to mammalian cells, but more studies are required to clarify th...		DHFR , Antifolate , Antibacterial
T6120	Pralatrexate	Folotyn,10-Propargyl-10-deazaaminopterin	Apoptosis , DHFR , Antifolate , TAM Receptor
	Pralatrexate (10-Propargyl-10-deazaaminopterin) is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive act...		Apoptosis , DHFR , Antifolate , TAM Receptor
T17257	WR99210		DHFR , Antifolate , Antibacterial
	WR99210 is a potent, orally available and less toxic dihydrofolate reductase (DHFR) inhibitor (IC50<0.075 nM). WR99210 has good antiparasitic activity against P. vivax and P. falciparum strains (including P. falciparum s...		DHFR , Antifolate , Antibacterial
T27002	CH-1504	CH 1504,MobileTrex
	CH-1504, dihydrofolate reductase (DHFR) inhibitor, is used potentially for the treatment of rheumatoid arthritis.
T40619	Tetroxoprim	HE 781,Tetroxoprim
	Tetroxoprim is an antimicrobial DHFR inhibitor.
T24966	11-Oxahomoaminopterin	NSC-325304,NSC 325304,NSC325304
	11-Oxahomoaminopterin exhibits antifolate activity against two folate-requiring microorganisms and inhibited Lactobacillus casei DHFR.
T60726	OYYF-175
	OYYF-175 is an antimicrobial antifolate. OYYF-175 exhibits potent broad-spectrum antibacterial activities, especially against multi-drug resistant Gram-Negative-strains. OYYF-175 is an inhibitor of dihydrofolate reductas...
T0189L	Pemetrexed disodium	LY-231514,LY231514 disodium,Pemetrexed	Apoptosis , DHFR , DNA/RNA Synthesis , Antifolate , Autophagy
	Pemetrexed disodium (LY-231514) is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesothelioma. Pemetrexed disodium therapy has b...
T60938	EGFR/HER2-IN-8
	EGFR/HER2-IN-8 (compound 34) is an inhibitor of EGFR/HER2 and DHFR with IC50 values of 0.45, 0.244 and 5.669 μM for EGFR, HER2 and DHFR, respectively. EGFR/HER2-IN-8 can be used in the cancer research that exhibits antic...
T61272	EGFR/HER2-IN-7
	EGFR/HER2-IN-7 is a highly selective and potent anticancer compound specifically designed to target MCF-7 breast cancer cells. It functions as a dual inhibitor, targeting both EGFR/HER2 kinases and DHFR (dihydrofolate re...
T79192	DQn-1
	DQn-1, a potent antifolate, demonstrates efficacy against Mycobacterium tuberculosis (Mtb) with an MIC 90 of 0.03 µM. It inhibits the DHFR enzyme, exhibiting IC 50 values of 8.7 nM for Mtb DHFR and 7.6 nM for the human c...
T25981	Pralatrexate, (S)-
	Pralatrexate, (S)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively ...
T25980	Pralatrexate, (R)-
	Pralatrexate, (R)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively ...
T0189	Pemetrexed	Pemetrexed acid,LY231514,LY-231514 Disodium Hydrate	DHFR , DNA/RNA Synthesis , Antifolate , Autophagy
	Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).		DHFR , DNA/RNA Synthesis , Antifolate , Autophagy
T60699	Aditoprime
	Aditoprime (Aditoprim) is a selective inhibitor of bacterial dihydrofolate reductase (DHFR) that inhibits the transformation of dihydrofolic acid to tetrahydrofolic acid. Aditoprime shows good antibacterial activity and ...
T61732	EGFR/HER2-IN-6
	EGFR/HER2-IN-6 (compound 43) is a dual EGFR/HER2 and DHFR inhibitor with potent activity against EGFR kinase, HER2 kinase, and DHFR, characterized by IC50 values of 0.122 μM, 0.078 μM, and 0.585 μM, respectively. This co...
T78238	4′-DTMP	4-Demethyltrimethoprim	DHFR , Antifungal
	4′-DTMP (4-Demethyltrimethoprim) is a potent DHFR inhibitor with antimicrobial activity that induces additional local interactions with the enzyme and inhibits Escherichia coli.		DHFR , Antifungal
T70304	CI-898 HCl
	CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1...
T68684	Piritrexim isethionate
	Piritrexim isethionate is a lipid-soluble inhibitor of dihydrofolate reductase (DHFR) that appears to be an active agent in patients with metastatic urothelial cancer when administered as a 5-day, low-dose oral schedule.
T73085	Talotrexin	PT523
	Talotrexin (PT523), an analog of Aminopterin, is a nonpolyglutamatable classic antifolate that acts as a specific inhibitor of the reduced folate carrier (RFC). It selectively inhibits RFC transport, demonstrating antitu...
T41148	Phototrexate
	Phototrexate is a photoswitchable potent inhibitor of human dihydrofolate reductase (DHFR). Phototrexate is a photochromic analog of Methotrexate. Antifolate activity is switched on (cis-Phototrexate) by UVA (375 nm) lig...
T79912	NSC309401
	NSC309401 is an E. coli dihydrofolate reductase inhibitor, displaying potency with an IC50 value of 189 nM and a dissociation constant (KD) of 14.57 nM [1].
T81639	NSC309401 dihydrochloride
	NSC309401 is an E. coli dihydrofolate reductase inhibitor with an IC50 value of 189 nM and a dissociation constant (Kd) of 14.57 nM [1].
T78964	Antileishmanial agent-17		Parasite
	Antileishmanial agent-17, a coumarin hybrid, exhibits potent antileishmanial activity (IC50 <0.78 μM) while proving non-toxic to normal VERO cells. It specifically interacts with the folate pathway enzymes pteridine redu...		Parasite
T68656	Brivudine monophosphate
	Brivudine monophosphate is a phosphate ester of Brivudine. Brivudine, also known as bromovinyl-deoxyuridine, is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. In vitro, bro...

Compounds

DHFR-IN-3

T3693

Synonym: 7-bromoquinazoline-2,4-diamine

Synonym: HZ1157,DHFR-inhibitor

EGFR/HER2/DHFR-IN-2

T82493

Synonym:

Target: EGFR

EGFR/HER2/DHFR-IN-3

T82492

Synonym:

Target: EGFR

EGFR/HER2/DHFR-IN-1

PROTAC eDHFR Degrader-1

Synonym: Pirimecidan,RP 4753,Pirimetamin

Target: DHFR, Antifolate, Parasite

Pemetrexed disodium hemipenta hydrate

T6226

Synonym: Pemetrexed Disodium Hydrate,LY-231514 Disodium Hydrate,Pemetrexed sodium hydrate

Target: Apoptosis, DHFR, DNA/RNA Synthesis, Antifolate, Autophagy

Methotrexate

T1485

Synonym: NCI-C04671,WR19039,Amethopterin,CL14377

Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis, Antifolate

Antibacterial agent 26

T61159

Synonym:

Target: Antibacterial

Brodimoprim

T19858

Synonym:

Target: DHFR, Antibacterial

Synonym: EGIS-5645,CCRIS-3784,AI3-23935

Target: DHFR, Antifolate, Antibacterial

Pralatrexate

T6120

Synonym: Folotyn,10-Propargyl-10-deazaaminopterin

Target: Apoptosis, DHFR, Antifolate, TAM Receptor

WR99210

T17257

Synonym:

Target: DHFR, Antifolate, Antibacterial

CH-1504

T27002

Synonym: CH 1504,MobileTrex

Target:

Tetroxoprim

T40619

Synonym: HE 781,Tetroxoprim

Target:

11-Oxahomoaminopterin

T24966

Synonym: NSC-325304,NSC 325304,NSC325304

Synonym: LY-231514,LY231514 disodium,Pemetrexed

Target: Apoptosis, DHFR, DNA/RNA Synthesis, Antifolate, Autophagy

Synonym: Pemetrexed acid,LY231514,LY-231514 Disodium Hydrate

Target: DHFR, DNA/RNA Synthesis, Antifolate, Autophagy

Synonym: 4-Demethyltrimethoprim

Target: DHFR, Antifungal

Piritrexim isethionate

NSC309401 dihydrochloride

T81639

Synonym:

Target:

Antileishmanial agent-17

T78964

Synonym:

Target: Parasite

Brivudine monophosphate

T68656

Synonym:

Target:

Cat No.	Product Name	Species	Expression System
TMPH-01224	Dihydrofolate reductase Protein, Human, Recombinant (His)	Human	E. coli
	Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds...
TMPH-03535	Dihydrofolate reductase Protein, S. aureus, Recombinant (His & Myc)	Staphylococcus aureus	E. coli
	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
TMPH-03581	Dihydrofolate reductase Protein, S. epidermidis, Recombinant (His)	Staphylococcus epidermidis	E. coli
	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

Search Result

Targets

Compounds

Recombinant Proteins

Compounds

Recombinant Proteins