CTX-1

CTX1 is a small molecule activator of p53.

CTX-1211 is a selective and orally active melanocortin 4 receptor (MC4R) agonist with an EC50 of 0.38 nM. It enhances the effects of liraglutide in suppressing food intake and promoting weight loss, supporting anorectic and weight-reducing activities. CTX-1211 is primarily employed in research related to obesity and other metabolic disorders.

Psalmotoxin 1 is a potent and selective acid-sensing ion channel 1a (ASIC1a) blocker.

Psalmotoxin 1 (PcTx1) TFA is a protein toxin that binds to the subunit interfaces of acid-sensing ion channel 1a (ASIC1a). It selectively and effectively inhibits ASIC1a by enhancing its apparent affinity for H+ (IC50: 0.9 nM). Psalmotoxin 1 TFA induces apoptosis and inhibits cancer cell migration, proliferation, and invasion. This compound is applicable in cancer or neurological disease research.

Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity. Temozolomide has antitumor activity and antiangiogenic activity, and also induces apoptosis and autophagy. Temozolomide is stable under acidic conditions and hydrolyzes under neutral or slightly alkaline conditions.

Avibactam sodium (NXL-104) is a non-β-lactam β-lactamase inhibitor that inhibits TEM-1, P99, and KPC-2 β-lactamases (IC50=8/80/38 nM) covalently and reversibly. Avibactam sodium has antimicrobial activity and can be used to treat urinary tract infections.

Avibactam free acid is a potent β-lactamase inhibitor exhibiting covalent and reversible properties, capable of inhibiting TEM-1, P99, and CTX-M-15 at nanomolar concentrations. Avibactam free acid and Ceftazidime may be combined for treating urinary tract infections.

5β-Cholestane-3α,7α,12α,25-tetrol is a type of bile acid alcohol that activates the G protein-coupled bile acid receptor 1 (GPBAR1), also known as TGR5, in HEK293 cells that express the human receptor, at concentrations between 0.1 to 10 µM. In individuals with cerebrotendinous xanthomatosis (CTX), a progressive metabolic leukodystrophy, levels of this compound are elevated in the blood, feces, and bile.

ANT3310 is an inhibitor of broad-spectrum covalent Serine β-Lactamase with IC50s ranging from 1 nM to 175 nM for AmpC, CTX-M-15, TEM-1, OXA-48, OXA-23, and KPC-2. ANT3310 can be used in studies about bacterial infection.

Avibactam sodium hydrate (NXL-104 hydrate) is a highly effective β-lactamase inhibitor that inhibits β-lactamases TEM-1 and CTX-M-15, as well as the carbapenemase produced by Klebsiella pneumoniae and carbapenem-resistant Enterobacteriaceae.

Avibactam sodium (NXL-104) dihydrate inhibits CTX-M-15 and β-lactamase TEM-1 with IC50 values of 5 nM and 8 nM, respectively, and is a reversible covalent inhibitor of non-β-lactam β-lactamase [1].

FPI-1465 is a dual inhibitor of serine-β-Lactamases and Penicillin-binding proteins (PBPs), demonstrating inhibition of PBP2 with an IC50 of 1.0 μg/mL. Additionally, it exhibits activity against β-lactamase CTX-M-15 and OXA-48, with dissociation constants (Kd) of 0.011 μM and 5.3 μM, respectively [1].

Desacetylcefotaxime, an in vivo metabolite of Cefotaxime (CTX), exhibits noteworthy in vitro antimicrobial efficacy, akin to its parent compound, against a broad spectrum of aerobic and anaerobic bacteria [1].

CTX-471 is a fully humanized monoclonal antibody targeting CD137, exhibiting agonistic activity and binding affinity (Kd=50/61/748 nM) to recombinant human, cynomolgus monkey, and mouse CD137. It enhances T cell and natural killer cell activation, making it suitable for studying immunomodulation and cancer.

CTX-2026 is a fully human antibody that targets and binds to CD277. CTX-2026 demonstrates anti-tumor effects in ovarian tumor models , and CTX-2026 is utilized in oncology research focused on immune receptor targeting, tumor microenvironment modulation, and antibody-based targeting of CD277-expressing cellular systems.

Avibactam-13C5,15N sodium (NXL-104-13C5,15N sodium) is an isotope-labeled version of Avibactam with 13C and 15N markers. Avibactam (NXL-104) in its free acid form is a covalent, reversible, non-β-lactam β-lactamase inhibitor, effectively inhibiting the β-lactamases TEM-1 and CTX-M-15, with IC50 values of 8 nM and 5 nM, respectively.

Cardiotoxin Analog (CTX) IV (6-12) TFA, a partial peptide of Cardiotoxin Analog IV, is derived from the venom of the Taiwan Cobra, showcasing the unique properties of snake venom cardiotoxin.