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Search Result

Search Results for " bace "

Targets

BACE BACE

43

Compounds

14

Natural Products

6

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T3161L BACE-IN-1 acetate BACE-IN-1 acetate (350228-37-4，Free base) BACE
BACE-IN-1 acetate (BACE-IN-1 acetate (350228-37-4，Free base)) has been used as β-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) inhibitor in BACE1 inhibitor assay. β-Site amyloid precursor protein (APP) c...
T10449 BACE-1 inhibitor 1 Others
BACE-1 inhibitor 1 (Compound 8a) is an effective BACE-1 inhibitor (IC50: 56 nM).
T62181 BACE-IN-1
BACE-IN-1 is an imidazo[1,2-a]pyridine derivative that inhibits the β-site amyloid precursor protein cleavage enzyme (BACE) sentence.BACE-IN-1 has the potential to investigate diseases involving BACE, such as Alzheimer's...
T62995 BACE-1 inhibitor 2
BACE-1 Inhibitor 2 is a potent, CNS-permeable inhibitor of BACE-1, exhibiting an IC50 value of 1.5 nM in enzymatic assays [1].
T60691 AChE/BChE/BACE-1-IN-2
AChE/BChE/BACE-1-IN-2 (Compound 4o) exhibits remarkable antioxidant potential and considerable binding capability towards PAS-AChE. AChE/BChE/BACE-1-IN-2 is an orally active AChE, BACE-1 and BChE inhibitor with IC 50 val...
T61206 AChE/BChE/BACE-1-IN-1
AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor that targets acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-site amyloid precursor protein cleaving enzyme 1 (BACE-1). It displays IC50 ...
T11175 Elenbecestat E2609 Beta-Secretase , BACE
Elenbecestat (E2609) is an effective oral bioutilization and CNS penetrating ACE-1 inhibitor for the treatment of Alzheimer's disease.
T12188 NB-360 BACE
NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cat...
T2639 LY2811376 Beta Amyloid , Beta-Secretase , BACE
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition...
T13253 Umibecestat CNP520 BACE
Umibecestat is an inhibitor of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively. Umibecestat can be used for the research of al...
T6058 LY2886721 Beta-Secretase , BACE
LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.
T6772 AZD3839 free base AZD3839 Beta-Secretase , BACE
AZD3839 free base is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.
T4398 LX2343 Beta Amyloid , Beta-Secretase , BACE , PI3K , Autophagy
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance.
T7011 Verubecestat MK-8931 Beta-Secretase , BACE
Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.
T10451 BACE1-IN-2 BACE
BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).
T10453 BACE1-IN-5 Beta Amyloid , BACE
BACE1-IN-5 (Compound 15), a potent β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, demonstrates significant efficacy with an IC50 of 9.1 nM for BACE1 inhibition and an impressive IC50 of 0.82 nM aga...
T10450 BACE1-IN-1 BACE
BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).
T10452 BACE1-IN-4 BACE
BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.
T3285 Eslicarbazepine Acetate Zebinix,Aptiom,BIA 2-093,Exalief,Stedesa Beta-Secretase , Sodium Channel
Eslicarbazepine Acetate (Zebinix) is an anticonvulsant medication approved for use in Europe, the United States and Canada as an adjunctive therapy for partial-onset seizures that are not adequately controlled with conve...
T3161 β-Secretase inhibitor-STA Beta-Secretase
BACE-IN-1 is amyloid precursor protein beta-secretase inhibitor
T39484 BACE1-IN-6 BACE1-IN-6
BACE1-IN-6 is a BACE1 inhibitor with an IC 50 value of 1.5 nM.
T62719 AChE/BACE1/GSK3β-IN-1
AChE/BACE1/GSK3β-IN-1 is an orally active, blood-brain barrier-transparent, moderately bioavailable triple inhibitor of AChE/BACE1/GSK3β. AChE/BACE1/GSK3β-IN-1 can be used to study Alzheimer's disease (AD).
T79022 BACE1-IN-13 Beta-Secretase
BACE1-IN-13 (Compound 36), an orally active inhibitor of BACE1, exhibits high potency with an IC50 of 2.9 nM and demonstrates greater efficacy in hAβ42 cells (IC50 = 1.3 nM). It is considered safe for the cardiovascular ...
T63867 BACE1-IN-12
BACE1-IN-12 is a potent BACE1 inhibitor (IC50: 8.9 μM) that can cross the blood-brain barrier. BACE1-IN-12 selectively inhibits BuChE (butylcholinesterase) activity (IC50: 3.2 μM). BACE1-IN-12 has potential for anti-Alzh...
T73098 BACE2-IN-1
BACE2-IN-1, a potent BACE2 inhibitor characterized by its exceptional selectivity and a Ki value of 1.6 nM, is utilized in the investigation of Type 2 Diabetes.
T61956 BACE1/2-IN-1
BACE1/2-IN-1 (compound 34) is an effective BACE1 and BACE2 inhibitor with IC50 of 0.01 and 0.0053 μM, respectively. BACE1/2-IN-1 has lower Pgp efflux ratio and improved passive permeability. The metabolic stability of BA...
T77906 Briobacept BR 3FC
Briobacept (BR 3FC), a selective human monoclonal antibody, targets BLyS (BAFF) to induce B-cell apoptosis and is a recombinant glycoprotein comprising two BLyS receptor (BR3) molecules fused to the Fc domain of human Ig...
T124932 Fabacein
Fabacein is a useful organic compound for research related to life sciences and the catalog number is T124932.
T64074 BACE1-IN-8
BACE1-IN-8 is a potent inhibitor of BACE1 (β-site APP lyase 1) (IC50: 3.9 μM).
T80129 Baceridin Proteasome
Baceridin, a cyclic hexapeptide and proteasome inhibitor, can be isolated from the culture medium of Epiphytic Bacillus. It has the ability to impede cell cycle progression and induce apoptosis in tumor cells via a p53-i...
T73076 BACE1-IN-10 Beta-Secretase
BACE1-IN-10 is a potent inhibitor of BACE1, demonstrating sub-micromolar activity against recombinant BACE1 (rBACE1) [1].
T83616 SEW06622 BACE , AChE
SEW06622 is a potent inhibitor of acetylcholinesterase (AChE) and beta-secretase-1 (BACE-1) and is a potential candidate for the treatment of Alzheimer's disease.
T13434 β-Secretase Inhibitor IV Others
β-Secretase Inhibitor IV is a potent, cell-active inhibitor of BACE-1(IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively).
T71383 NB-533
NB-533 is a macrocyclic peptidic BACE-1 inhibitor.
T68278 NB-216
NB-216 is a macrocyclic peptidic BACE-1 inhibitor.
T83686 Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 acetate
Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 is a fluorogenic substrate designed for the quantification of β-secretase (BACE) activity. When cleaved by BACE, it liberates 7-methoxycoumarin-4-acetyl (Mca), a compound whose fluorescence, ...
T27944 LY3202626 LY 3202626,LY-3202626
LY3202626, an amyloid precursor protein secretase (BACE protein) inhibitor, is used for the treatment of Alzheimer's disease.
T37661 LY 2886721 Hydrochloride
Potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin a...
T26705 AZ-4217 AZ4217,AZ 4217
AZ-4217 is a high potency BACE inhibitor. It displays acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice. AZ-4217 has IC50 160 pM in human SH-SY5Y cells with an excellent in ...
T81836 Mca-SEVNLDAEFK(Dnp)-NH2
Mca-SEVNLDAEFK(Dnp)-NH2 is a fluorogenic substrate featuring a 7-methoxycoumarin moiety whose fluorescence is quenched by the adjacent 2,4-dinitrophenyl group through resonance energy transfer. This compound serves as a ...
T70800 Elenbecestat free base
Elenbecestat,also known as E2609 is a BACE1 inhibitor. By inhibiting BACE, a key enzyme in the production of Aβ peptides, E2609 decreases the formation of these peptides which can aggregate into toxic oligomers and proto...
T79299 HAChE-IN-3 Monoamine Oxidase
hAChE-IN-3 (compound 5c) serves as a potent inhibitor for AChE, BuChE, MAO-B, and BACE-1, with respective IC50 values of 0.44, 0.08, 5.15, and 0.38 μM, demonstrating its ability to cross the blood-brain barrier. This com...
T62180 CB1/2 agonist 2
CB1/2 agonist 2 (compound 23) is a potent non-selective cannabinoid ligand with Ki of 3.5 nM and 1.2 nM, respectively. CB1/2 agonist 2 is a full agonist of CB1 and a competitive inverse agonist of CB2. BACE-IN-1 is a com...

Compounds

BACE-IN-1 acetate
T3161L
Synonym: BACE-IN-1 acetate (350228-37-4，Free base)
Target: BACE
BACE-1 inhibitor 1
T10449
Synonym:
Target: Others
BACE-IN-1
T62181
Synonym:
Target:
BACE-1 inhibitor 2
T62995
Synonym:
Target:
AChE/BChE/BACE-1-IN-2
T60691
Synonym:
Target:
AChE/BChE/BACE-1-IN-1
T61206
Synonym:
Target:
Elenbecestat
T11175
Synonym: E2609
Target: Beta-Secretase, BACE
NB-360
T12188
Synonym:
Target: BACE
LY2811376
T2639
Synonym:
Target: Beta Amyloid, Beta-Secretase, BACE
Umibecestat
T13253
Synonym: CNP520
Target: BACE
LY2886721
T6058
Synonym:
Target: Beta-Secretase, BACE
AZD3839 free base
T6772
Synonym: AZD3839
Target: Beta-Secretase, BACE
LX2343
T4398
Synonym:
Target: Beta Amyloid, Beta-Secretase, BACE, PI3K, Autophagy
Verubecestat
T7011
Synonym: MK-8931
Target: Beta-Secretase, BACE
BACE1-IN-2
T10451
Synonym:
Target: BACE
BACE1-IN-5
T10453
Synonym:
Target: Beta Amyloid, BACE
BACE1-IN-1
T10450
Synonym:
Target: BACE
BACE1-IN-4
T10452
Synonym:
Target: BACE
Eslicarbazepine Acetate
T3285
Synonym: Zebinix,Aptiom,BIA 2-093,Exalief,Stedesa
Target: Beta-Secretase, Sodium Channel
β-Secretase inhibitor-STA
T3161
Synonym:
Target: Beta-Secretase
BACE1-IN-6
T39484
Synonym: BACE1-IN-6
Target:
AChE/BACE1/GSK3β-IN-1
T62719
Synonym:
Target:
BACE1-IN-13
T79022
Synonym:
Target: Beta-Secretase
BACE1-IN-12
T63867
Synonym:
Target:
BACE2-IN-1
T73098
Synonym:
Target:
BACE1/2-IN-1
T61956
Synonym:
Target:
Briobacept
T77906
Synonym: BR 3FC
Target:
Fabacein
T124932
Synonym:
Target:
BACE1-IN-8
T64074
Synonym:
Target:
Baceridin
T80129
Synonym:
Target: Proteasome
BACE1-IN-10
T73076
Synonym:
Target: Beta-Secretase
SEW06622
T83616
Synonym:
Target: BACE, AChE
β-Secretase Inhibitor IV
T13434
Synonym:
Target: Others
NB-533
T71383
Synonym:
Target:
NB-216
T68278
Synonym:
Target:
Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 acetate
T83686
Synonym:
Target:
LY3202626
T27944
Synonym: LY 3202626,LY-3202626
Target:
LY 2886721 Hydrochloride
T37661
Synonym:
Target:
AZ-4217
T26705
Synonym: AZ4217,AZ 4217
Target:
Mca-SEVNLDAEFK(Dnp)-NH2
T81836
Synonym:
Target:
Elenbecestat free base
T70800
Synonym:
Target:
hAChE-IN-3
T79299
Synonym:
Target: Monoamine Oxidase
CB1/2 agonist 2
T62180
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T5S2361 Epiberberine ERK , Beta-Secretase , MEK , BACE , AMPK , AChR , AChE
1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways during 3T3-L1 adipocyte diffe...
T3769 Tenuifolin Others , Beta-Secretase , AChE
Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.
T8179 Aloeresin D Beta-Secretase , BACE
Aloeresin D, a natural chromone glycoside, inhibits β-Secretase (BACE1) activity (IC50: 39 μM).
TN2190 Scoulerine Apoptosis , Beta-Secretase , BACE , Parasite
Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.
T2S1181 Aloenin Aloenin A,Aloearbonaside Beta-Secretase , AChR
1. Aloenin (Aloenin A) and aloe-emodin are active principles for inhibition of c-ADH and c-ALDH activities in vitro.
TN2217 Sophoflavescenol Others , Beta-Secretase , BACE , PDE , AChR , AChE
Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , these effects might contribute to the antitumor activity witho...
T8306 Epiberberine chloride Epiberberine (chloride) Reactive Oxygen Species , Beta-Secretase , BACE , AChR , AChE
Epiberberine chloride (Epiberberine (chloride)) is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07, 6.03 and 8.55 μM).
TN7076 Herbacetin-3,8-diglucopyranoside Linocinamarin Others
herbacetin-3,8-diglucopyranoside (Linocinamarin) is a natural product.
T5S1331 Herbacetin c-Met/HGFR , Akt
1. Herbacetin induces apoptosis in HepG2 cells, by ROS and PI3K/Akt pathway. 2. Herbacetin suppresses the HGF-induced motility of human breast cancer MDA-MB-231 cells by inhibiting c-Met and Akt phosphorylation.
T82214 Herbacetin-3-sophoroside-8--glucoside
Herbacetin-3-sophoroside-8-glucoside is a naturally occurring compound that can be extracted from Equisetum hyemale [1].
TN3410 Anatabine Beta Amyloid , IL Receptor , TNF , NF-κB , BACE , COX , STAT
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheimer's disease effects, it inhibits BACE-1 transcription and r...
TN1332 7-O-Methylaloeresin A BACE
7-O-Methylaloeresin A shows significant antioxidant activity, it also has moderate inhibitory active on BACE.
TN1434 Bavachromene BACE
Bavachromene exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro.
T79960 Aloveroside A
Aloveroside A, a triglucosylnaphthalene derivative extracted from Aloe vera using ethanol, exhibits modest inhibitory activity against bACE, demonstrating approximately 18.68% inhibition at a concentration of 100 μg/mL [...

Natural Products

Epiberberine
T5S2361
Synonym:
Target: ERK, Beta-Secretase, MEK, BACE, AMPK, AChR, AChE
Tenuifolin
T3769
Synonym:
Target: Others, Beta-Secretase, AChE
Aloeresin D
T8179
Synonym:
Target: Beta-Secretase, BACE
Scoulerine
TN2190
Synonym:
Target: Apoptosis, Beta-Secretase, BACE, Parasite
Aloenin
T2S1181
Synonym: Aloenin A,Aloearbonaside
Target: Beta-Secretase, AChR
Sophoflavescenol
TN2217
Synonym:
Target: Others, Beta-Secretase, BACE, PDE, AChR, AChE
Epiberberine chloride
T8306
Synonym: Epiberberine (chloride)
Target: Reactive Oxygen Species, Beta-Secretase, BACE, AChR, AChE
herbacetin-3,8-diglucopyranoside
TN7076
Synonym: Linocinamarin
Target: Others
Herbacetin
T5S1331
Synonym:
Target: c-Met/HGFR, Akt
Herbacetin-3-sophoroside-8--glucoside
T82214
Synonym:
Target:
Anatabine
TN3410
Synonym:
Target: Beta Amyloid, IL Receptor, TNF, NF-κB, BACE, COX, STAT
7-O-Methylaloeresin A
TN1332
Synonym:
Target: BACE
Bavachromene
TN1434
Synonym:
Target: BACE
Aloveroside A
T79960
Synonym:
Target:

Recombinant Proteins

Species：
Human (3)
Mouse (2)
Human (1)
Expression System：
HEK293 (5)
Human Cells (1)
Tag：
His (3)
C-Fc (1)
Tag Free (1)
hFc (1)
Cat No. Product Name Species Expression System
TMPY-00752 BACE1 Protein, Human, Recombinant (His) Human HEK293
Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus c...
TMPY-00651 BACE1 Protein, Human, Recombinant (hFc) Human HEK293
Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus c...
TMPY-00652 BACE1 Protein, Human, Recombinant Human HEK293
Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus c...
TMPY-00678 BACE1 Protein, Mouse, Recombinant (His) Mouse HEK293
Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus c...
TMPY-03065 BACE2 Protein, Mouse, Recombinant (His) Mouse HEK293
BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is th...
TMPJ-00782 Amyloid Precursor Protein, Human, Recombinant (hFc) Human Human Cells
Amyloid precursor protein (APP) is a type I membrane protein with several isoforms due to alternative splicing, performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and...
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