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Search Result

Search Results for "antifolate"

Targets

Antifolate

Compounds

Cat No. Product Name
T26636 Antifolate C2 AGF154,AGF 154,AGF-154
Antifolate C2 is an inhibitor of de novo purine biosynthesis. Antifolate C2 has selectivity for cellular uptake by high ...
T26635 Antifolate C1 AGF-94,AGF94,AGF 94
Antifolate C1 is an inhibitor of de novo purine biosynthesis. Antifolate C1 has selectivity for cellular uptake by high ...
T6226 Pemetrexed disodium hemipenta hydrate 培美曲塞二钠一水合物,培美曲塞二钠水合物,Pemetrexed Disodium Hydrate,Pemetrexed sodium hydrate,LY-231514 Disodium Hydrate Antifolate , Autophagy , DNA/RNA Synthesis , DHFR , Apoptosis
Pemetrexed Disodium Hydrate 是一种叶酸拮抗剂。抑制胸苷酸合成酶 (TS)，二氢叶酸还原酶 (DHFR) 和甘氨酰胺核苷酸甲酰转移酶 (GARFT)，Ki 分别为 1.3 nM，7.2 nM 和 65 nM。
T16045 Methotrexate metabolite 甲喋呤杂质E,DAMPA Drug Metabolite , Antifolate
Methotrexate metabolite (DAMPA)是 Methotrexate 的活性代谢物。Methotrexate 具有拮抗叶酸 (folic acid) 的作用，被用作免疫抑制剂。
T8548 Metoprine Histamine Receptor , Antifolate , Histone Methyltransferase
Metoprine 是一种有效的组胺 N-甲基转移酶抑制剂，具有抗肿瘤活性。它是一种二氨基嘧啶衍生物，可以透过血脑屏障，并通过抑制 HMT 增加脑组胺水平。
T36692 Fanotaprim DHFR
Fanotaprim 是二氢叶酸还原酶的有效抑制剂，抑制 tgDHFR (Toxoplasma gondiiDHFR) 和 hDHFR (human DHFR)的 IC50分别为 1.57 和 308 nM。Fanotaprim 在研究弓形...
T7730 Aminopterin 4-Aminofolic acid,APGA,氨基蝶呤 Antifolate
Aminopterin 是叶酸的 4-氨基衍生物，是叶酸拮抗剂，具有抗癌和免疫抑制活性，用于研究儿童白血病。它催化叶酸还原为四氢叶酸，竞争性抑制二氢叶酸还原酶，Ki 值为 3.7 pM。
T2204 Diaveridine 二氨藜芦啶,敌菌净,CCRIS-3784,EGIS-5645,AI3-23935 DHFR , Antibacterial , Antifolate
Diaveridine 是二氢叶酸还原酶的抑制剂，对于野生型 DHFR 的Ki 值为 11.5 nM。它也是一种抗菌剂。
T6431 Levoleucovorin Calcium CL307782,Calcium Levofolinate,左亚叶酸钙 Others , Antifolate
Calcium Levofolinate 是一种亚叶酸的钙盐，在癌症化疗中用作辅助剂。
T7593 Levomefolate calcium 左旋甲状腺素钙,L-5-甲基四氢叶酸钙 Antifolate
Levomefolate calcium 是一种人工形式的叶酸。它是叶酸的一种辅酶形式，是膳食补充剂中生物利用度更高的替代品。
T4382 Proguanil hydrochloride Chlorguanide hydrochloride,Paludrine hydrochloride,Chloroquanil,盐酸氯胍 Others , Parasite , Antifolate , DNA/RNA Synthesis , Dehydrogenase
Proguanil hydrochloride 是一种双胍类抗疟疾剂，在体内代谢形成环胍。它还是一种二氢叶酸还原酶抑制剂。
T0148 Folinic acid calcium Folinic acid calcium salt,亚叶酸钙,Wellcovorin,Calcium folinate,Leucovorin Calcium DNA/RNA Synthesis , Endogenous Metabolite , Antifolate
Calcium folinate 是叶酸的活性代谢物，是一种解毒剂，通常与甲氨蝶呤 (MTX) 联用，以降低 MTX 诱导的毒性。
T0189L Pemetrexed disodium Pemetrexed,LY-231514,LY231514 disodium,培美曲塞二钠,培美曲塞二钠盐 Autophagy , Antifolate , DNA/RNA Synthesis , DHFR , Apoptosis
Pemetrexed disodium 是一种叶酸拮抗剂，用于治疗非小细胞肺癌和恶性间皮瘤。它抑制胸苷酸合成酶，二氢叶酸还原酶和甘氨酰胺核苷酸甲酰转移酶的Ki 分别为 1.3 nM，7.2 nM 和 65 nM。
T0189 Pemetrexed LY231514,Pemetrexed acid,LY-231514 Disodium Hydrate,培美曲塞,培美曲唑 DNA/RNA Synthesis , DHFR , Antifolate , Autophagy
Pemetrexed acid 是一种鸟嘌呤衍生的抗肿瘤药物，可结合并抑制胸苷酸合酶、二氢叶酸还原酶和甘氨酰胺核苷酸甲酰转移酶的 Ki 分别为 1.3 nM、7.2 nM 和 65 nM。
T0849 Pyrimethamine RP 4753,Pirimetamin,Pirimecidan,乙胺嘧啶 Antifolate , DHFR , Parasite
Pyrimethamine 是一种二氢叶酸还原酶的竞争性抑制剂，用作抗疟药。
T15826 Lometrexol LY 264618,DDATHF DHFR
Lometrexol 是一种抗嘌呤类抗叶酸 (Antifolate) 药，可抑制甘氨酰胺核糖核苷酸甲酰基转移酶 (GARFT) 的活性，但不会引起可检测水平的 DNA 链断裂。Lometrexol 可以进一步抑制嘌呤从头合成，导致异常的细胞...
T3693 7-Bromo-2,4-diaminoquinazoline 7-bromoquinazoline-2,4-diamine,7-溴-2,4-二氨基喹唑啉 Others
7-Bromo-2,4-diaminoquinazoline 是一种活性生化剂。
T64295 Talotrexin ammonium DHFR
Talotrexin ammonium 是一种不可多聚谷氨酸抗叶酸类药物。Talotrexin ammonium 通过针对二氢叶酸还原酶（DHFR）来抑制肿瘤生长，从而提高了在广泛癌症模型中的抗肿瘤活性，有助于抑制肿瘤的增长。
T8003 Methotrexate disodium Antifolate , DNA/RNA Synthesis , Apoptosis , Dehydrogenase
Methotrexate disodium 是一种叶酸类似物代谢抑制剂，具有免疫抑制剂和抗肿瘤特性，用于类风湿关节炎和研究多种癌症。
T0148L Folinic Acid Calcium Salt Pentahydrate Leucovorin calcium salt pentahydrate,Leucovorin Calcium Pentahydrate,Folinic acid,亚叶酸钙五水合物 Antifolate , Others
Folinic acid calcium salt pentahydrate 是一种还原型叶酸，是一种解毒剂，通常与甲氨蝶呤 (MTX) 联用，以降低 MTX 诱导的毒性。
Antifolate C2
T26636
synonym: AGF154,AGF 154,AGF-154
Target:
Antifolate C1
T26635
synonym: AGF-94,AGF94,AGF 94
Target:
Pemetrexed disodium hemipenta hydrate
T6226
synonym: 培美曲塞二钠一水合物,培美曲塞二钠水合物,Pemetrexed Disodium Hydrate,Pemetrexed sodium hydrate,LY-231514 Disodium Hydrate
Target:
Methotrexate metabolite
T16045
synonym: 甲喋呤杂质E,DAMPA
Target:
Metoprine
T8548
synonym:
Target:
Fanotaprim
T36692
synonym:
Target:
Aminopterin
T7730
synonym: 4-Aminofolic acid,APGA,氨基蝶呤
Target:
Diaveridine
T2204
synonym: 二氨藜芦啶,敌菌净,CCRIS-3784,EGIS-5645,AI3-23935
Target:
Levoleucovorin Calcium
T6431
synonym: CL307782,Calcium Levofolinate,左亚叶酸钙
Target:
Levomefolate calcium
T7593
synonym: 左旋甲状腺素钙,L-5-甲基四氢叶酸钙
Target:
Proguanil hydrochloride
T4382
synonym: Chlorguanide hydrochloride,Paludrine hydrochloride,Chloroquanil,盐酸氯胍
Target:
Folinic acid calcium
T0148
synonym: Folinic acid calcium salt,亚叶酸钙,Wellcovorin,Calcium folinate,Leucovorin Calcium
Target:
Pemetrexed disodium
T0189L
synonym: Pemetrexed,LY-231514,LY231514 disodium,培美曲塞二钠,培美曲塞二钠盐
Target:
Pemetrexed
T0189
synonym: LY231514,Pemetrexed acid,LY-231514 Disodium Hydrate,培美曲塞,培美曲唑
Target:
Pyrimethamine
T0849
synonym: RP 4753,Pirimetamin,Pirimecidan,乙胺嘧啶
Target:
Lometrexol
T15826
synonym: LY 264618,DDATHF
Target:
7-Bromo-2,4-diaminoquinazoline
T3693
synonym: 7-bromoquinazoline-2,4-diamine,7-溴-2,4-二氨基喹唑啉
Target:
Talotrexin ammonium
T64295
synonym:
Target:
Methotrexate disodium
T8003
synonym:
Target:
Folinic Acid Calcium Salt Pentahydrate
T0148L
synonym: Leucovorin calcium salt pentahydrate,Leucovorin Calcium Pentahydrate,Folinic acid,亚叶酸钙五水合物
Target:
1 2 3
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