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  • Antibacterial
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Results for "Antifolate" in TargetMol Product Catalog
  • Inhibitor Products
    45
    TargetMol | Activity
  • Natural Products
    4
    TargetMol | inventory
  • PROTAC Products
    2
    TargetMol | natural
  • Recombinant Protein
    4
    TargetMol | composition
Antifolate C2
T266361286279-90-0In house
Antifolate C2 (AGF 154) has antitumor activity with an IC of 0.14 nM measured in a growth inhibition assay of human tumor cells.Antifolate C2 can be used for the study of cancer and autoimmune diseases.
  • $350
In Stock
Size
QTY
Antifolate C1
T26635136784-51-5
Antifolate C1 is an inhibitor of de novo purine biosynthesis. Antifolate C1 has selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter (PCFT) over the reduced folate carrier (RFC).
  • $2,120
8-10 weeks
Size
QTY
Methotrexate
T148559-05-2
Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and various tumors.
  • $38
In Stock
Size
QTY
TargetMol | Citations Cited
Trimethoprim
T1153738-70-5
Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Transporter 2 Inhibitor.
  • $45
In Stock
Size
QTY
Pemetrexed
T0189137281-23-3
Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).
  • $33
In Stock
Size
QTY
Folinic acid calcium
T01481492-18-8
Folinic acid calcium (Leucovorin Calcium) is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists.
  • $42
In Stock
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QTY
P 218
T73328L1142407-60-0In house
P 218 is a novel DHFR inhibitor with antimalarial activity and antifolate effects and can be used to study Buruli ulcer.
  • $129
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Proguanil hydrochloride
T4382637-32-1
Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.
  • $50
In Stock
Size
QTY
Talotrexin ammonium
T64295648420-92-2In house
Talotrexin ammonium is a non-polyglutamic acid antifolate. Talotrexin ammonium inhibits tumor growth by targeting dihydrofolate reductase (DHFR), thereby improving anti-tumor activity in a wide range of cancer models, helping to inhibit tumor growth.
  • $350
In Stock
Size
QTY
Phototrexate
T411482268033-83-4In house
Phototrexate is a photoswitchable potent inhibitor of human dihydrofolate reductase (DHFR). Phototrexate is a photochromic analog of Methotrexate. Antifolate activity is switched on (cis-Phototrexate) by UVA (375 nm) light; it can be switched off (trans-Phototrexate) by blue or white light and by thermal relaxation in the dark.cis-Phototrexate (IC50 = 6 nM) significantly reduces the viability of HeLa cells compared withtrans-Phototrexate (IC50 = 34 μM).
  • $628
35 days
Size
QTY
TargetMol | Inhibitor Sale
Methotrexate metabolite
T1604519741-14-1In house
Methotrexate metabolite (DAMPA) (DAMPA) is the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist. Methotrexate is used as a chemotherapeutic agent and immunosuppressant.
  • $39
In Stock
Size
QTY
Lometrexol
T15826106400-81-1In house
Lometrexol (LY 264618), an antipurine Antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit de novo purine synthesis, causing abnormal cell proliferation and Apoptosis, even cell cycle arrest. Lometrexol has anticancer activity. Lometrexol also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor.
  • $98
In Stock
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LSN 3213128
T118841941211-99-9In house
LSN 3213128, anti-tumor activity. is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC50 of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells.
  • $1,430
6-8 weeks
Size
QTY
TargetMol | Inhibitor Sale
Pemetrexed disodium hemipenta hydrate
T6226357166-30-4
Pemetrexed disodium hemipenta hydrate (LY-231514 Disodium Hydrate) is a new-type antifolate and antimetabolite for TS, DHFR, and GARFT. The Ki of Pemetrexed Disodium Hydrate for TS, DHFR and GARFT is 1.3 nM, 7.2 nM and 65 nM, respectively.
  • $33
In Stock
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TargetMol | Citations Cited
Calcium N5-methyltetrahydrofolate
T759826560-38-3
Calcium N5-methyltetrahydrofolate (NSC-173328) is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers
  • $76
In Stock
Size
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TargetMol | Inhibitor Sale
Fanotaprim
T366922120282-75-7
Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor. Fanotaprim inhibits the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM and a hDHFR IC50 of 308 ± 71 nM and a hDHFR to TgDHFR selectivity ratio of 196.
  • $80
In Stock
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TargetMol | Inhibitor Sale
DHFR-IN-3
T3693137553-43-6
DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) is a dihydrofolate reductase (DHFR) inhibitor.
  • $41
In Stock
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TargetMol | Inhibitor Sale
1,1,3-Tribromoacetone
T740093475-39-6
1,1,3-Tribromoacetone is an impurity of Methotrexate [1]. Methotrexate is an antimetabolite and antifolate drug that blocks the enzyme dihydrofolate reductase, stopping the transformation of folic acid into tetrahydrofolate and inhibiting DNA synthesis [1].
    Inquiry
    TNP-351
    T26283125991-51-7
    Tnp 351 is a novel antifolate drug being assessed for chemotherapy of lung cancer.
    • $1,820
    8-10 weeks
    Size
    QTY
    Levoleucovorin Calcium
    T643180433-71-2
    Levoleucovorin Calcium (CL307782), a calcium salt of the folinic acid, is used in cancer chemotherapy as an adjuvant.
    • $36
    In Stock
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    Pralatrexate
    T6120146464-95-1
    Pralatrexate (10-Propargyl-10-deazaaminopterin) is a folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities.
    • $30
    In Stock
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    PD 130883
    T28326123685-36-9
    PD 130883 is a potent lipophilic quinazoline antifolate.
    • $1,520
    6-8 weeks
    Size
    QTY
    Diaveridine
    T22045355-16-8
    Diaveridine (AI3-23935) (DVD) is a popular antibacterial synergist that is widely used in combination with sulfonamide. It has been reported to be genotoxic to mammalian cells, but more studies are required to clarify this.
    • $33
    In Stock
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    Metoprine
    T85487761-45-7
    Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.
    • $55
    In Stock
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    Talotrexin
    T73085113857-87-7
    Talotrexin (PT523), an analog of Aminopterin, is a nonpolyglutamatable classic antifolate that acts as a specific inhibitor of the reduced folate carrier (RFC). It selectively inhibits RFC transport, demonstrating antitumor activity by targeting dihydrofolate reductase (DHFR) to inhibit tumor growth [1] [2].
    • $1,520
    6-8 weeks
    Size
    QTY
    Folinic Acid Calcium Salt Pentahydrate
    T0148L6035-45-6
    Folinic Acid Calcium Salt Pentahydrate (Leucovorin Calcium Pentahydrate), a reduced folic acid, is used in combination with other chemotherapeutics.
    • $41
    In Stock
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    CI-898 HCl
    T703041658520-97-8
    CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1/S phase in L1210 mouse lymphocytic leukemia cells and is active against methotrexate-resistant cancer cell lines. It also enhances the activity of doxorubicin, cyclophosphamide, and 6-thioguanine (6-TG) in mice with advanced stage P338 leukemia.
    • $1,520
    6-8 weeks
    Size
    QTY
    Pyrimethamine
    T084958-14-0
    Pyrimethamine (Pirimecidan) is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.
    • $38
    In Stock
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    LY 254155
    T11922135503-67-2
    LY 254155, an antifolate,binds to mFBP and inhibits hGARFT with Kis of 1.7±0.1 and 2.1±0.2 nM, respectively.
    • $2,570
    10-14 weeks
    Size
    QTY
    Methotrexate disodium
    T80037413-34-5
    Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor
    • $34
    In Stock
    Size
    QTY
    Levomefolate calcium
    T7593151533-22-1
    Levomefolate calcium is an artificial form of folate. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements.
    • $39
    In Stock
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    DDCPPB-Glu
    T25296149325-95-1
    DDCPPB-Glu is a 6-5 fused ring heterocycle antifolate that shows antitumor activity.
    • $2,270
    10-14 weeks
    Size
    QTY
    Edatrexate
    T6866180576-83-6
    Edatrexate (CGP 30694), also known as 10-Ethyl-10-deazaaminopterin, is an analog of Methotrexate that demonstrates antitumor activity against Methotrexate-resistant tumors. This antifolate antimetabolite is utilized in research related to non-small-cell lung cancer, breast cancer, non-Hodgkin's lymphoma, and head and neck cancer [1] [2].
    • $1,520
    6-8 weeks
    Size
    QTY
    11-Oxahomoaminopterin
    T2496678520-72-6
    11-Oxahomoaminopterin exhibits antifolate activity against two folate-requiring microorganisms and inhibited Lactobacillus casei DHFR.
    • $3,020
    10-14 weeks
    Size
    QTY
    Antileishmanial agent-22
    T79633
    Antileishmanial agent-22 (compound 15b) serves as an antiparasitic and antibacterial, exhibiting activities against Leishmania (IC50 = 0.408 μM), malaria, and tuberculosis. It operates on an antifolate mechanism, suppressing both folic and folinic acids with 88% and 94% efficacy at 100 μM, respectively. This compound also demonstrates a 96.67% inhibitory effect on P. berghei in vivo/in vitro at 48.4 μM/kg/day and 0.038 μM (IC50), and it inhibits M. tuberculosis with an MIC of 28.44 μM [1].
    • Inquiry Price
    Size
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    DQn-1
    T7919257343-54-1
    DQn-1, a potent antifolate, demonstrates efficacy against Mycobacterium tuberculosis (Mtb) with an MIC 90 of 0.03 µM. It inhibits the DHFR enzyme, exhibiting IC 50 values of 8.7 nM for Mtb DHFR and 7.6 nM for the human counterpart [1].
    • Inquiry Price
    Size
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    WR99210
    T1725747326-86-3
    WR99210 is a potent, orally available and less toxic dihydrofolate reductase (DHFR) inhibitor (IC50<0.075 nM). WR99210 has good antiparasitic activity against P. vivax and P. falciparum strains (including P. falciparum strains resistant to Pyrimethamine ) and T. gondii.
    • $108
    5 days
    Size
    QTY
    Aminopterin
    T773054-62-6
    Aminopterin (4-Aminofolic acid) is a synthetic folic acid derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase
    • $41
    In Stock
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    QTY
    Arfolitixorin
    T2665431690-11-6
    Arfolitixorin is an antifolate modulator.
    • $1,520
    6-8 weeks
    Size
    QTY
    Pemetrexed disodium
    T0189L150399-23-8
    Pemetrexed disodium (LY-231514) is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesothelioma. Pemetrexed disodium therapy has been associated with moderate rates of serum enzyme elevations during therapy, but has not been convincingly linked to instances of acute, clinically apparent liver injury.
    • $37
    In Stock
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    Lometrexol hydrate
    T412971435784-14-7
    Lometrexol hydrate (DDATHF hydrate) is an antipurine antifolate compound that inhibits glycinamide ribonucleotide formyltransferase (GARFT) activity without inducing detectable DNA strand breaks. It further disrupts de novo purine synthesis, leading to abnormal cell proliferation, apoptosis, and cell cycle arrest, exhibiting anticancer activity [1] [2]. Additionally, it acts as a potent inhibitor of human Serine hydroxymethyltransferase1/2 (h SHMT1/2) [3].
    • $2,300
    10-14 weeks
    Size
    QTY
    N-Methyl pemetrexed
    T74111869791-42-4
    N-Methyl pemetrexed, an impurity found in Pemetrexed, serves as an antifolate cytotoxic agent utilized in cancer research [1].
    • Inquiry Price
    Size
    QTY
    Lometrexol disodium
    T63240120408-07-3
    Lometrexol (DDATHF) disodium is a potent inhibitor of human serine hydroxymethyltransferase 1/2 (hSHMT1/2) and antifolate, which reduces the activity of glycinamide ribonucleotide formyltransferase (GARFT) without causing detectable levels of DNA strand breaks. Lometrexol disodium exhibits anticancer effects by inhibiting the de novo synthesis of purines, causing abnormal cell proliferation, apoptosis and cell cycle arrest.
    • $2,300
    10-14 weeks
    Size
    QTY
    OYYF-175
    T6072665829-22-3
    OYYF-175 is an antimicrobial antifolate. OYYF-175 exhibits potent broad-spectrum antibacterial activities, especially against multi-drug resistant Gram-Negative-strains. OYYF-175 is an inhibitor of dihydrofolate reductase (DHFR) with an IC 50 of 2.36 nM for Escherichia coli DHFR.
    • $1,520
    6-8 weeks
    Size
    QTY
    ICI 198583
    T25519112887-62-4
    ICI 198583 is an inhibitor of antifolate thymidylate synthase.
    • $1,670
    6-8 weeks
    Size
    QTY